PE20081778A1 - Disolucion solida amorfa que contiene un derivado de pirazol-3-carboxamida en forma amorfa y excipientes estabilizadores - Google Patents
Disolucion solida amorfa que contiene un derivado de pirazol-3-carboxamida en forma amorfa y excipientes estabilizadoresInfo
- Publication number
- PE20081778A1 PE20081778A1 PE2008000359A PE2008000359A PE20081778A1 PE 20081778 A1 PE20081778 A1 PE 20081778A1 PE 2008000359 A PE2008000359 A PE 2008000359A PE 2008000359 A PE2008000359 A PE 2008000359A PE 20081778 A1 PE20081778 A1 PE 20081778A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxamide
- solution containing
- amorphous
- pyrazole
- stabilizing excipients
- Prior art date
Links
- 239000000546 pharmaceutical excipient Substances 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- BNYCHCAYYYRJSH-UHFFFAOYSA-N 1h-pyrazole-5-carboxamide Chemical class NC(=O)C1=CC=NN1 BNYCHCAYYYRJSH-UHFFFAOYSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 229920002101 Chitin Polymers 0.000 abstract 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000006104 solid solution Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A FORMAS AMORFAS DE DERIVADOS DE PIRAZOL-3-CARBOXAMIDA TALES COMO N-PIPERIDIN-5-(4-BROMOFENIL)-1-(2,4-DICLOROFENIL)-4-ETILPIRAZOL-3-CARBOXAMIDA Y N-PIPERIDIN-5-(4-CLOROFENIL)-1-(2,4-DICLOROFENIL)-4-METILPIRAZOL-3-CARBOXAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA DISOLUCION SOLIDA AMORFA QUE CONTIENE UNO DE LOS DERIVADOS DE PIRAZOL-3-CARBOXAMIDA JUNTO A EXCIPIENTES ESTABILIZADORES TALES COMO ACIDO CITRICO, ACIDO FUMARICO, UN COPOLIMERO DE METACRILATO, COPOLIMEROS VINILICOS, POLIDEXTROSAS, POLIMEROS CELULOSICOS, PECTINAS, DERIVADOS DE QUITINA, POLIETILENGLICOLES, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0701377A FR2913018A1 (fr) | 2007-02-23 | 2007-02-23 | Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081778A1 true PE20081778A1 (es) | 2009-01-01 |
Family
ID=38561793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000359A PE20081778A1 (es) | 2007-02-23 | 2008-02-20 | Disolucion solida amorfa que contiene un derivado de pirazol-3-carboxamida en forma amorfa y excipientes estabilizadores |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100076023A1 (es) |
| EP (1) | EP2132182A2 (es) |
| JP (1) | JP2010519246A (es) |
| KR (1) | KR20090113305A (es) |
| CN (1) | CN101641333A (es) |
| AR (1) | AR065410A1 (es) |
| AU (1) | AU2008240507A1 (es) |
| BR (1) | BRPI0807575A2 (es) |
| CA (1) | CA2678801A1 (es) |
| CL (1) | CL2008000550A1 (es) |
| CO (1) | CO6210812A2 (es) |
| EA (1) | EA200970792A1 (es) |
| FR (1) | FR2913018A1 (es) |
| IL (1) | IL200370A0 (es) |
| MA (1) | MA31244B1 (es) |
| MX (1) | MX2009008991A (es) |
| PE (1) | PE20081778A1 (es) |
| TW (1) | TW200846339A (es) |
| UY (1) | UY30937A1 (es) |
| WO (1) | WO2008129157A2 (es) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2713225B1 (fr) * | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
| FR2761266B1 (fr) * | 1997-03-28 | 1999-07-02 | Sanofi Sa | Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| FR2873372B1 (fr) * | 2004-07-22 | 2006-09-08 | Sanofi Synthelabo | Procede de preparation de derives n-piperidino-1,5- diphenylpyrazole-3-carboxamide |
| EP1844017A1 (en) * | 2005-01-06 | 2007-10-17 | Cadila Healthcare Ltd. | An amorphous and three crystalline forms of rimonabant hydrochloride |
| AR052660A1 (es) * | 2005-01-21 | 2007-03-28 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir la cdk's y gsk's |
| KR100678824B1 (ko) * | 2005-02-04 | 2007-02-05 | 한미약품 주식회사 | 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물 |
| DE102005026755A1 (de) * | 2005-06-09 | 2006-12-14 | Basf Ag | Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung |
| EP1816125A1 (en) * | 2006-02-02 | 2007-08-08 | Ranbaxy Laboratories, Ltd. | Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof |
| WO2007103711A2 (en) * | 2006-03-01 | 2007-09-13 | Dr. Reddy's Laboratories Ltd. | Polymorphic forms of rimonabant |
| US8431609B2 (en) * | 2007-02-19 | 2013-04-30 | Darmesh Mahendrabhai Shah | Process for preparation of pyrazole derivatives |
-
2007
- 2007-02-23 FR FR0701377A patent/FR2913018A1/fr active Pending
-
2008
- 2008-02-20 EP EP08775573A patent/EP2132182A2/fr not_active Withdrawn
- 2008-02-20 KR KR1020097017532A patent/KR20090113305A/ko not_active Withdrawn
- 2008-02-20 BR BRPI0807575-1A patent/BRPI0807575A2/pt not_active IP Right Cessation
- 2008-02-20 JP JP2009550302A patent/JP2010519246A/ja active Pending
- 2008-02-20 MX MX2009008991A patent/MX2009008991A/es not_active Application Discontinuation
- 2008-02-20 AU AU2008240507A patent/AU2008240507A1/en not_active Abandoned
- 2008-02-20 EA EA200970792A patent/EA200970792A1/ru unknown
- 2008-02-20 CN CN200880009562A patent/CN101641333A/zh active Pending
- 2008-02-20 PE PE2008000359A patent/PE20081778A1/es not_active Application Discontinuation
- 2008-02-20 CA CA002678801A patent/CA2678801A1/fr not_active Abandoned
- 2008-02-20 WO PCT/FR2008/000216 patent/WO2008129157A2/fr not_active Ceased
- 2008-02-21 AR ARP080100705A patent/AR065410A1/es unknown
- 2008-02-21 TW TW097106126A patent/TW200846339A/zh unknown
- 2008-02-22 CL CL200800550A patent/CL2008000550A1/es unknown
- 2008-02-22 UY UY30937A patent/UY30937A1/es not_active Application Discontinuation
-
2009
- 2009-08-12 IL IL200370A patent/IL200370A0/en unknown
- 2009-08-19 US US12/543,942 patent/US20100076023A1/en not_active Abandoned
- 2009-08-19 CO CO09087002A patent/CO6210812A2/es unknown
- 2009-09-10 MA MA32210A patent/MA31244B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008129157A3 (fr) | 2008-12-31 |
| KR20090113305A (ko) | 2009-10-29 |
| IL200370A0 (en) | 2010-04-29 |
| AU2008240507A1 (en) | 2008-10-30 |
| BRPI0807575A2 (pt) | 2014-07-01 |
| WO2008129157A2 (fr) | 2008-10-30 |
| WO2008129157A4 (fr) | 2009-03-05 |
| CL2008000550A1 (es) | 2008-07-04 |
| CA2678801A1 (fr) | 2008-10-30 |
| AR065410A1 (es) | 2009-06-03 |
| US20100076023A1 (en) | 2010-03-25 |
| EP2132182A2 (fr) | 2009-12-16 |
| CO6210812A2 (es) | 2010-10-20 |
| MA31244B1 (fr) | 2010-03-01 |
| MX2009008991A (es) | 2009-09-03 |
| UY30937A1 (es) | 2008-09-30 |
| EA200970792A1 (ru) | 2010-04-30 |
| CN101641333A (zh) | 2010-02-03 |
| FR2913018A1 (fr) | 2008-08-29 |
| TW200846339A (en) | 2008-12-01 |
| JP2010519246A (ja) | 2010-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |