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PE20080369A1 - CYANOPYRIDINES SUBSTITUTED AS PROTEIN KINASE INHIBITORS - Google Patents

CYANOPYRIDINES SUBSTITUTED AS PROTEIN KINASE INHIBITORS

Info

Publication number
PE20080369A1
PE20080369A1 PE2007000747A PE2007000747A PE20080369A1 PE 20080369 A1 PE20080369 A1 PE 20080369A1 PE 2007000747 A PE2007000747 A PE 2007000747A PE 2007000747 A PE2007000747 A PE 2007000747A PE 20080369 A1 PE20080369 A1 PE 20080369A1
Authority
PE
Peru
Prior art keywords
nicotinonitrile
cyanopyridines
substituted
protein kinase
kinase inhibitors
Prior art date
Application number
PE2007000747A
Other languages
Spanish (es)
Inventor
Derek Cecil Cole
Magda Asselin
Diane Harris Boschelli
Yanong Daniel Wang
Amarnauth Shastrie Prashad
Russell DUSHIN
Allan Wissner
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080369A1 publication Critical patent/PE20080369A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE CIANOPIRIDINA DE FORMULAS (I) O (I'), DONDE X ES NR3-Y, O-Y, C(O)O-Y, S(O)m-Y, ENTRE OTROS; Y ES ALQUILO C1-C10, ALQUENILO C2-C10, HALOALQUILO C1-C10, ENTRE OTROS; R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON UNO A CUATRO GRUPOS -Y-R4; R2 ES ARILO C6-C14 O UN HETEROARILO DE 5 A 14 MIEMBROS, OPCIONALMENTE SUSTITUIDOS CON -Y-R4 U -O-Y-R4; R4 ES HALOGENO, CN, NO2, UN GRUPO OXO, ENTRE OTROS; m ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 4-[(3-CLOROFENIL)AMINO]-5-(3,4-DIMETOXIFENIL)NICOTINONITRILO, 5-(3,4-DIMETOXIFENIL)-4-[(3-FLUORFENIL)AMINO]NICOTINONITRILO, 4-ANILINO-5-(3,4-DIMETOXIFENIL)NICOTINONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINA QUINASAS Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNESREFERRING TO A CYANOPYRIDINE DERIVATIVE OF FORMULAS (I) O (I '), WHERE X IS NR3-Y, O-Y, C (O) O-Y, S (O) m-Y, AMONG OTHERS; AND IT IS C1-C10 ALKYL, C2-C10 ALKENYL, C1-C10 HALOALKYL, AMONG OTHERS; R1 IS OPTIONALLY SUBSTITUTE PHENYL WITH ONE TO FOUR GROUPS-AND-R4; R2 IS C6-C14 ARYL OR A 5 TO 14-MEMBER HETEROARYL, OPTIONALLY REPLACED WITH -Y-R4 OR -O-Y-R4; R4 IS HALOGEN, CN, NO2, AN OXO GROUP, AMONG OTHERS; m IS 0, 1 OR 2. PREFERRED COMPOUNDS ARE: 4 - [(3-CHLOROPHENYL) AMINO] -5- (3,4-DIMETOXIPHENIL) NICOTINONITRILE, 5- (3,4-DIMETOXIFENIL) -4 - [(3- FLUORPHENIL) AMINO] NICOTINONITRILE, 4-ANILINO-5- (3,4-DIMETOXIFENIL) NICOTINONITRILE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF PROTEIN KINASES AND ARE USEFUL IN THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

PE2007000747A 2006-06-13 2007-06-13 CYANOPYRIDINES SUBSTITUTED AS PROTEIN KINASE INHIBITORS PE20080369A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81318206P 2006-06-13 2006-06-13

Publications (1)

Publication Number Publication Date
PE20080369A1 true PE20080369A1 (en) 2008-06-04

Family

ID=38832510

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000747A PE20080369A1 (en) 2006-06-13 2007-06-13 CYANOPYRIDINES SUBSTITUTED AS PROTEIN KINASE INHIBITORS

Country Status (12)

Country Link
EP (1) EP2027093A2 (en)
JP (1) JP2009539993A (en)
CN (1) CN101454287A (en)
AR (1) AR061367A1 (en)
AU (1) AU2007258352A1 (en)
BR (1) BRPI0712776A2 (en)
CA (1) CA2650666A1 (en)
CL (1) CL2007001738A1 (en)
MX (1) MX2008015805A (en)
PE (1) PE20080369A1 (en)
TW (1) TW200815356A (en)
WO (1) WO2007146323A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011001319A (en) 2008-08-06 2011-04-05 Vertex Pharma Aminopyridine kinase inhibitors.
CN103408489A (en) * 2013-08-29 2013-11-27 武穴市永宁医药化工有限公司 Preparation method of 3-cyanopyridine oxynitride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215823D0 (en) * 2002-07-09 2002-08-14 Astrazeneca Ab Quinazoline derivatives
JP2006512338A (en) * 2002-12-12 2006-04-13 ファルマシア・コーポレーション Use of aminocyanopyridines as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
JP2008540656A (en) * 2005-05-18 2008-11-20 ワイス 3-cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same
PE20080336A1 (en) * 2006-06-13 2008-06-03 Wyeth Corp 3-CYANOPYRIDINES SUBSTITUTED AS PROTEIN KINASE INHIBITORS

Also Published As

Publication number Publication date
CA2650666A1 (en) 2007-12-21
AR061367A1 (en) 2008-08-20
JP2009539993A (en) 2009-11-19
TW200815356A (en) 2008-04-01
MX2008015805A (en) 2009-01-09
WO2007146323A3 (en) 2008-04-17
AU2007258352A1 (en) 2007-12-21
CN101454287A (en) 2009-06-10
EP2027093A2 (en) 2009-02-25
WO2007146323A2 (en) 2007-12-21
BRPI0712776A2 (en) 2013-12-17
CL2007001738A1 (en) 2008-01-18

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