PE20080427A1 - ANTIVIRAL AGENTS - Google Patents
ANTIVIRAL AGENTSInfo
- Publication number
- PE20080427A1 PE20080427A1 PE2007000902A PE2007000902A PE20080427A1 PE 20080427 A1 PE20080427 A1 PE 20080427A1 PE 2007000902 A PE2007000902 A PE 2007000902A PE 2007000902 A PE2007000902 A PE 2007000902A PE 20080427 A1 PE20080427 A1 PE 20080427A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxi
- quinolin
- pyrrol
- thiazol
- dimethyl
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Y ES ARILO, HETEROARILO, HETEROARILO SUSTITUIDO, ENTRE OTROS; HET ES ARILENO DE 6 MIEMBROS, UN HETEROARILENO DE 6 MIEMBROS QUE CONTIENE 1, 2 o 3 HETEROATOMOS SELECCIONADOS ENTRE N, O, S Y UN ANILLO BICICLICO DE FORMULAS II, III, ENTRE OTROS; W1, W4 Y W5 SON CADA UNO N, CH; W3 ES N, CH, UNA UNION CON LA SALVEDAD DE QUE NO MAS QUE UN NITROGENO EN EL ANILLO BICICLICO SE OXIDA OPCIONALMENTE PARA FORMAR N-OXIDO; LA LINEA PUNTEADA ES UN ENLACE DOBLE O SIMPLE; UNO DE D o E C-Ra, Y EL OTRO DE D o E ES S; Ra Y R SON CADA UNO H, ALQUILO, ALQUILO SUSTITUIDO; Q ES CICLOALQUILO SUSTITUIDO O NO, CICLOALQUENILO, HETEROCICLO, ENTRE OTROS; Z ES CARBOXI, CARBOXI ESTER, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 6-CICLOPENTIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-4-(2-MORFOLIN-4-IL-2-OXO-ETIL)-4H-TIENO[3,2-b]PIRROL-2-CARBOXILICO; ACIDO {6-CICLOHEXIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-2-METANSULFONILAMINOCARBONIL-TIENO[3,2-b]PIRROL-4-IL}-ACETICO; ENTRE OTROS. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE HEPATITIS C MEDIADA POR EL VIRUS FLAVIVIRIDAEREFERS TO A COMPOUND OF FORMULA I, WHERE AND IS ARYL, HETEROARYL, SUBSTITUTE HETEROARYL, AMONG OTHERS; HET IS ARYLENE OF 6 MEMBERS, A HETEROARYLENE OF 6 MEMBERS CONTAINING 1, 2 or 3 HETEROATOMS SELECTED FROM N, O, S AND A BICYCLE RING OF FORMULAS II, III, AMONG OTHERS; W1, W4 AND W5 ARE EACH N, CH; W3 IS N, CH, A JOINT EXCEPT THAT NO MORE THAN ONE NITROGEN IN THE BICYCLE RING IS OPTIONALLY OXIDIZED TO FORM N-OXIDE; THE DOTTED LINE IS A DOUBLE OR SIMPLE LINK; ONE OF D or E C-Ra, AND THE OTHER OF D or E IS S; Ra AND R ARE EACH H, RENT, REPLACED RENT; Q IS CYCLOALKYL SUBSTITUTED OR NOT, CYCLOALKENYL, HETEROCICLO, AMONG OTHERS; Z IS CARBOXI, CARBOXI ESTER, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 6-CYCLOPENTIL-5- [2- (2,4-DIMETHYL-THIAZOL-5-IL) -QUINOLIN-6-IL] -4- (2-MORFOLIN-4-IL-2-OXO- ETHYL) -4H-HAVE [3,2-b] PYRROL-2-CARBOXYL; ACID {6-CYCLOHEXYL-5- [2- (2,4-DIMETHYL-THIAZOL-5-IL) -QUINOLIN-6-IL] -2-METANSULPHONYLAMINOCARBONYL-HAVE [3,2-b] PYRROL-4-IL} -ACETIC; AMONG OTHERS. SAID COMPOUND IS USEFUL IN THE TREATMENT OF HEPATITIS C MEDIATED BY THE FLAVIVIRIDAE VIRUS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83104006P | 2006-07-14 | 2006-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080427A1 true PE20080427A1 (en) | 2008-06-11 |
Family
ID=38742551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000902A PE20080427A1 (en) | 2006-07-14 | 2007-07-13 | ANTIVIRAL AGENTS |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2044083A1 (en) |
| JP (1) | JP2009543807A (en) |
| KR (1) | KR20090033881A (en) |
| CN (1) | CN101490058A (en) |
| AR (1) | AR062258A1 (en) |
| AU (1) | AU2007272441A1 (en) |
| BR (1) | BRPI0714346A2 (en) |
| CA (1) | CA2657651A1 (en) |
| MX (1) | MX2009000513A (en) |
| PE (1) | PE20080427A1 (en) |
| RU (1) | RU2009105196A (en) |
| TW (1) | TW200813070A (en) |
| WO (2) | WO2008008907A2 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| EP2494991A1 (en) | 2007-05-04 | 2012-09-05 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
| US8362068B2 (en) | 2009-12-18 | 2013-01-29 | Idenix Pharmaceuticals, Inc. | 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors |
| JP5918264B2 (en) * | 2010-12-22 | 2016-05-18 | アッヴィ・インコーポレイテッド | Hepatitis C inhibitor and use thereof |
| US20120252721A1 (en) * | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| FR3008975A1 (en) | 2013-07-23 | 2015-01-30 | Servier Lab | NOVEL PYRROLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| RU2546006C1 (en) | 2014-03-07 | 2015-04-10 | Римма Ильинична Ашкинази | Antiviral agent |
| US10080728B2 (en) | 2015-01-20 | 2018-09-25 | Viktor Veniaminovich Tets | Hemostatic agent |
| US10167293B2 (en) * | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
| US11285170B2 (en) | 2017-05-24 | 2022-03-29 | Viktor Veniaminovich Tets | Fractionated antimicrobial compositions and use thereof |
| PE20240919A1 (en) * | 2021-04-16 | 2024-04-30 | Gilead Sciences Inc | THIENOPYRROL COMPOUNDS |
| EP4398989A1 (en) | 2021-09-10 | 2024-07-17 | Gilead Sciences, Inc. | Thienopyrrole compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007484B1 (en) * | 2001-06-11 | 2006-10-27 | Вирокем Фарма Инк. | Compounds and methods for the treatment or prevention of flavivirus infections |
| JP2006526663A (en) * | 2003-06-04 | 2006-11-24 | ジェネラブス テクノロジーズ インコーポレーティッド | Nitrogen-containing heteroaryl derivatives |
-
2007
- 2007-07-12 CA CA002657651A patent/CA2657651A1/en not_active Abandoned
- 2007-07-12 KR KR1020097001707A patent/KR20090033881A/en not_active Withdrawn
- 2007-07-12 WO PCT/US2007/073386 patent/WO2008008907A2/en not_active Ceased
- 2007-07-12 AU AU2007272441A patent/AU2007272441A1/en not_active Abandoned
- 2007-07-12 JP JP2009519699A patent/JP2009543807A/en active Pending
- 2007-07-12 EP EP07799544A patent/EP2044083A1/en not_active Withdrawn
- 2007-07-12 MX MX2009000513A patent/MX2009000513A/en not_active Application Discontinuation
- 2007-07-12 BR BRPI0714346-0A patent/BRPI0714346A2/en not_active Application Discontinuation
- 2007-07-12 RU RU2009105196/04A patent/RU2009105196A/en not_active Application Discontinuation
- 2007-07-12 WO PCT/US2007/073391 patent/WO2008008912A1/en not_active Ceased
- 2007-07-12 CN CNA2007800266569A patent/CN101490058A/en active Pending
- 2007-07-13 AR ARP070103144A patent/AR062258A1/en unknown
- 2007-07-13 TW TW096125693A patent/TW200813070A/en unknown
- 2007-07-13 PE PE2007000902A patent/PE20080427A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007272441A2 (en) | 2009-03-19 |
| WO2008008907A3 (en) | 2008-03-20 |
| EP2044083A1 (en) | 2009-04-08 |
| AU2007272441A1 (en) | 2008-01-17 |
| BRPI0714346A2 (en) | 2013-03-19 |
| TW200813070A (en) | 2008-03-16 |
| CN101490058A (en) | 2009-07-22 |
| WO2008008912A1 (en) | 2008-01-17 |
| AR062258A1 (en) | 2008-10-29 |
| KR20090033881A (en) | 2009-04-06 |
| MX2009000513A (en) | 2009-03-09 |
| WO2008008907A2 (en) | 2008-01-17 |
| RU2009105196A (en) | 2010-08-27 |
| CA2657651A1 (en) | 2008-01-17 |
| JP2009543807A (en) | 2009-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |