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PE20080421A1 - Derivados de 5,6-bisaril-2-piridin-carboxamida, su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de urotensina ii - Google Patents

Derivados de 5,6-bisaril-2-piridin-carboxamida, su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de urotensina ii

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Publication number
PE20080421A1
PE20080421A1 PE2007001066A PE2007001066A PE20080421A1 PE 20080421 A1 PE20080421 A1 PE 20080421A1 PE 2007001066 A PE2007001066 A PE 2007001066A PE 2007001066 A PE2007001066 A PE 2007001066A PE 20080421 A1 PE20080421 A1 PE 20080421A1
Authority
PE
Peru
Prior art keywords
alkyl
pyridin
cycloalkyl
halogen
phenyl
Prior art date
Application number
PE2007001066A
Other languages
English (en)
Inventor
Jean-Michel Altenburger
Valerie Fossey
Gilbert Lassalle
Frederic Petit
Jean Claude Vernieres
Philip Janiak
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20080421A1 publication Critical patent/PE20080421A1/es

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 5,6-BISARIL-2-PIRIDIN-CARBOXAMIDA DE FORMULA (I) DONDE X E Y SON CADA UNO N O CR3, DONDE R3 ES H, HALOGENO, ALCOXI(C1-C5) O ALQUILO(C1-C5); U ES H O NHR7, DONDE R7 ES H O ALQUILO(C1-C5); A ES ARILO(C5-C6), HETEROARILO O HETEROCICLOALQUILO(C3-C8) OPCIONALMENTE SUSTITUIDO; W ES HALOGENO, ALQUILO(C1-C5) O HALOGENOALQUILO(C1-C5); Z ES UN ENLACE, CICLOALQUILENO(C3-C8) O ALQUILENO(C1-C5) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI, ALQUILO(C1-C5) O ALCOXI(C1-C5); B ES NR4R5 O UN HETEROCICLO DE FORMULA (i), DONDE R4 Y R5 SON CADA UNO ALQUILO(C1-C5), CICLOALQUILO(C3-C8), FLUOROALQUILO(C1-C5), ENTRE OTROS; m Y n SON CADA UNO DE 0 A 2; R6 Y R7 SON CADA UNO H, ALQUILO(C1-C5) O CICLOALQUILO(C3-C8); R1 Y R2 SON CADA UNO H, ALQUILO(C1-C5), CICLOALQUILO(C3-C8), FENILO, BENCILO, ENTRE OTROS; p ES 0 O 1. SON COMPUESTOS PREFERIDOS: ACIDO 1-({[6-{4-CLORO-3-[3-(DIMETILAMINO)PROPOXI]FENIL}-5-(2,6-DIMETOXIFENIL)PIRIDIN-2-IL]CARBONIL}AMINO)CICLOHEXANOCARBOXILICO, CLORHIDRATO DE ACIDO 9-({[6-{4-CLORO-3-[3-(DIMETILAMINO)PROPOXI]FENIL}-5-(2,6-DIMETOXIFENIL)PIRIDIN-2-IL]CARBONIL}AMINO)BICICLO[3.3.1]NONANO-9-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE UROTENSINA II SIENDO UTILES EN EL TRATAMIENTO DE INSUFICIENCIA CARDIACA CONGESTIVA, ISQUEMIA CARDIACA, INFARTO DE MIOCARDIO, ANEURISMA
PE2007001066A 2006-08-11 2007-08-09 Derivados de 5,6-bisaril-2-piridin-carboxamida, su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de urotensina ii PE20080421A1 (es)

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FR0607283A FR2904827B1 (fr) 2006-08-11 2006-08-11 Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii

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FR2948119A1 (fr) * 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
FR2948120A1 (fr) 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyrimidine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l’urotensine ii
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IL196797A (en) 2013-07-31
RS52420B (sr) 2013-02-28
UY30534A1 (es) 2008-03-31
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JP2010500332A (ja) 2010-01-07
EP2059508B1 (fr) 2012-04-11
AR062294A1 (es) 2008-10-29
SI2059508T1 (sl) 2012-08-31
US20090318473A1 (en) 2009-12-24
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MY145644A (en) 2012-03-15
PL2059508T3 (pl) 2012-09-28
US8552201B2 (en) 2013-10-08
CN101511789A (zh) 2009-08-19
ATE553082T1 (de) 2012-04-15
AU2007285659A1 (en) 2008-02-21
KR20090050075A (ko) 2009-05-19
ES2385614T3 (es) 2012-07-27
US20120108611A1 (en) 2012-05-03
NZ574699A (en) 2011-10-28
IL196797A0 (en) 2009-11-18
TW200815393A (en) 2008-04-01
EP2059508A1 (fr) 2009-05-20
CA2659928A1 (fr) 2008-02-21
WO2008020124A1 (fr) 2008-02-21
FR2904827B1 (fr) 2008-09-19
EP2439193A1 (fr) 2012-04-11
GT200900026A (es) 2009-11-24
EA200970192A1 (ru) 2009-08-28
NO20090779L (no) 2009-05-05
PT2059508E (pt) 2012-07-03
TWI388551B (zh) 2013-03-11
DK2059508T3 (da) 2012-07-23
BRPI0716655A2 (pt) 2013-09-24
AU2007285659B2 (en) 2013-01-10
HRP20120559T1 (hr) 2012-07-31
MX2009001582A (es) 2009-02-19
FR2904827A1 (fr) 2008-02-15
CY1113129T1 (el) 2016-04-13
JP5230621B2 (ja) 2013-07-10
US8110579B2 (en) 2012-02-07
SG187993A1 (en) 2013-03-28
EP2439193B1 (fr) 2014-04-23
CO6150147A2 (es) 2010-04-20
CL2007002329A1 (es) 2008-03-07
ZA200900835B (en) 2010-06-30
MA30703B1 (fr) 2009-09-01
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