PE20071174A1 - Composiciones farmaceuticas para la erradicacion de helicobacter pylori - Google Patents
Composiciones farmaceuticas para la erradicacion de helicobacter pyloriInfo
- Publication number
- PE20071174A1 PE20071174A1 PE2006001688A PE2006001688A PE20071174A1 PE 20071174 A1 PE20071174 A1 PE 20071174A1 PE 2006001688 A PE2006001688 A PE 2006001688A PE 2006001688 A PE2006001688 A PE 2006001688A PE 20071174 A1 PE20071174 A1 PE 20071174A1
- Authority
- PE
- Peru
- Prior art keywords
- layer
- agents
- eradication
- stabilized against
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241000590002 Helicobacter pylori Species 0.000 title 1
- 230000008029 eradication Effects 0.000 title 1
- 229940037467 helicobacter pylori Drugs 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical class NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000011247 coating layer Substances 0.000 abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Chemical class 0.000 abstract 1
- 239000004471 Glycine Chemical class 0.000 abstract 1
- 241000589989 Helicobacter Species 0.000 abstract 1
- 102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 abstract 1
- 108010083204 Proton Pumps Proteins 0.000 abstract 1
- 239000004902 Softening Agent Substances 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
- 229960003022 amoxicillin Drugs 0.000 abstract 1
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical class OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
- 229960002626 clarithromycin Drugs 0.000 abstract 1
- 239000012055 enteric layer Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 229920000193 polymethacrylate Polymers 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000011241 protective layer Substances 0.000 abstract 1
- 238000007789 sealing Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA GRANULADA QUE COMPRENDE: A) 5-40 mg DE UN INHIBIDOR DE LA BOMBA DE PROTONES TAL COMO OMEPRAZOL CONTENIDA EN EL NUCLEO; B) UNA CAPA PROTECTORA; C) UNA CAPA ENTERICA DE POLIMETACRILATO; D) UNA CAPA DE SELLADO PROTECTORA OPCIONAL; E) UNA CAPA DE REVESTIMIENTO ESTABILIZADA FRENTE AL pH QUE COMPRENDE 50-1000mg DE CLARITROMICINA Y 100-2000mg DE AMOXICILINA; F) UNA CAPA EXTERNA FINAL PARA PROTEGER Y MEJORAR EL SABOR DE LA FORMULACION. LAS CAPAS DE REVESTIMIENTO ESTAN ESTABILIZADAS FRENTE AL pH CON UNA MEZCLA DE SALES SODICAS DE ACIDO FOSFORICO, ACIDO CITRICO, GLICINA Y ARGININA Y COMPRENDEN ADEMAS AGENTES TENSIOACTIVOS, ANTIESPUMANTES, AGENTES SUAVIZANTES Y FILMOGENOS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE TRASTORNOS GASTRICOS ASOCIADO CON HELICOBACTER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100029A EP1803450A1 (en) | 2006-01-03 | 2006-01-03 | Pharmaceutical compositions for the eradication of helicobacter pylori |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071174A1 true PE20071174A1 (es) | 2007-11-23 |
Family
ID=36587265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001688A PE20071174A1 (es) | 2006-01-03 | 2006-12-22 | Composiciones farmaceuticas para la erradicacion de helicobacter pylori |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1803450A1 (es) |
| AR (1) | AR058739A1 (es) |
| PE (1) | PE20071174A1 (es) |
| TW (1) | TW200744676A (es) |
| UY (1) | UY30065A1 (es) |
| WO (1) | WO2007077158A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2722039A3 (en) * | 2007-11-12 | 2014-08-13 | Pharmaceutics International, Inc. | Tri-molecular complexes and their use in drug delivery systems |
| RU2403904C1 (ru) * | 2009-02-26 | 2010-11-20 | Федеральное государственное учреждение "Научно-исследовательский институт по изучению лепры Федерального агентства по здравоохранению и социальному развитию Росздрава" | Способ профилактики острых гастродуоденальных язв у больных колоректальным раком в раннем послеоперационном периоде |
| IT1400415B1 (it) | 2010-05-26 | 2013-05-31 | Over S R L | Composizioni per il trattamento della infezione da helicobacter pylori. |
| CA2900763C (en) * | 2013-02-13 | 2021-04-06 | Reza Fathi | Pharmaceutical compositions for the treatment of helicobacter pylori |
| BR202014031413U2 (pt) * | 2014-12-15 | 2016-06-21 | Ems Sa | kit para administração conjunta de medicamentos |
| CN104940170A (zh) * | 2015-07-23 | 2015-09-30 | 浙江亚太药业股份有限公司 | 一种埃索美拉唑镁肠溶胶囊及其制备方法 |
| US11878011B2 (en) | 2020-05-07 | 2024-01-23 | Redhill Biopharma Ltd. | Method for eradicating Helicobacter pylori infection in patients regardless of body mass index |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9500422D0 (sv) | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| US5945124A (en) | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| US6132768A (en) | 1995-07-05 | 2000-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors |
| SI9700186B (sl) * | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6576625B2 (en) | 2001-03-16 | 2003-06-10 | Panacea Biotic Limited | Targeted vesicular constructs for cytoprotection and treatment of H. pylori infections |
| US20050163857A1 (en) | 2002-04-03 | 2005-07-28 | Ashok Rampal | Clarithromycin formulations having improved bioavailability |
| EP1492504A2 (en) | 2002-04-03 | 2005-01-05 | Ranbaxy Laboratories, Ltd. | Taste masked compositions of erythromycin a and derivatives thereof |
| US20040180935A1 (en) | 2003-02-28 | 2004-09-16 | Dr. Reddy's Laboratories Limited Dr. Reddy's Laboratories Inc. | Crystalline form Z of rabeprazole sodium and process for preparation thereof |
| KR100581967B1 (ko) * | 2003-12-18 | 2006-05-22 | 한국유나이티드제약 주식회사 | 소화성 궤양 치료를 위한 프로톤펌프 저해제와클래리스로마이신을 함유하는 이중 펠렛 제제 및 그의제조방법 |
| WO2005082331A2 (en) | 2004-02-26 | 2005-09-09 | Ranbaxy Laboratories Limited | Extended release tablets of clarithromycin |
-
2006
- 2006-01-03 EP EP06100029A patent/EP1803450A1/en not_active Withdrawn
- 2006-12-21 WO PCT/EP2006/070129 patent/WO2007077158A1/en not_active Ceased
- 2006-12-22 PE PE2006001688A patent/PE20071174A1/es not_active Application Discontinuation
- 2006-12-26 AR ARP060105782A patent/AR058739A1/es not_active Application Discontinuation
- 2006-12-26 UY UY30065A patent/UY30065A1/es unknown
- 2006-12-27 TW TW095149152A patent/TW200744676A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY30065A1 (es) | 2007-04-30 |
| EP1803450A1 (en) | 2007-07-04 |
| TW200744676A (en) | 2007-12-16 |
| WO2007077158A1 (en) | 2007-07-12 |
| AR058739A1 (es) | 2008-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |