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PE20071150A1 - Un proceso para preparar derivados de tetrahidroquinolina - Google Patents

Un proceso para preparar derivados de tetrahidroquinolina

Info

Publication number
PE20071150A1
PE20071150A1 PE2007000358A PE2007000358A PE20071150A1 PE 20071150 A1 PE20071150 A1 PE 20071150A1 PE 2007000358 A PE2007000358 A PE 2007000358A PE 2007000358 A PE2007000358 A PE 2007000358A PE 20071150 A1 PE20071150 A1 PE 20071150A1
Authority
PE
Peru
Prior art keywords
trifluoromethyl
ethyl
ona
quinolin
dihydro
Prior art date
Application number
PE2007000358A
Other languages
English (en)
Inventor
Masaki Okamoto
Akira Sakuragi
Yoshikazu Mori
Takeshi Hamada
Hitoshi Kubota
Yoshinori Nakamura
Takanori Higashijima
Norimitsu Hayashi
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of PE20071150A1 publication Critical patent/PE20071150A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA (I-a) O (2R,4S)-2-ETIL-6-TRIFLUOROMETIL-1,2,3,4-TETRAHIDROQUINOLIN-4-ILAMINA, QUE COMPRENDE: A) HACER REACCIONAR ACIDO (R)-3-AMINOVALERICO O SU ESTER ALQUILICO CON UN COMPUESTO DE FORMULA (I-f) PARA FORMAR ACIDO (R)-3-(4-TRIFLUOROMETIL-FENILAMINO)-VALERICO, DONDE L ES UN GRUPO SALIENTE; B) HACER REACCIONAR ACIDO (R)-3-(4-TRIFLUOROMETIL-FENILAMINO)-VALERICO CON PENTOXIDO DE FOSFORO EN PRESENCIA DE ACIDO METANSULFONICO PARA FORMAR (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA; C) CONVERTIR (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA EN OXIMA DE (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA O EN O-ALQUIALQUIL-OXIMA DE (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA; Y D) REALIZAR UNA REDUCCION CATALITICA DE LA OXIMA U O-ALQUIALQUIL-OXIMA EN PRESENCIA DEL CATALIZADOR DE PALADIO-CARBONO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I), (II), ENTRE OTROS. DICHO COMPUESTO OBTENIDO ES INHIBIDOR DE LA PROTEINA DE TRANSFERENCIA DE ESTER DE COLESTERILO (CETP) SIENDO UTIL EN EL TRATAMIENTO DE HIPERLIPIDEMIA
PE2007000358A 2006-03-30 2007-03-29 Un proceso para preparar derivados de tetrahidroquinolina PE20071150A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006092783 2006-03-30
JP2006322845 2006-11-30

Publications (1)

Publication Number Publication Date
PE20071150A1 true PE20071150A1 (es) 2007-12-03

Family

ID=38123770

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000358A PE20071150A1 (es) 2006-03-30 2007-03-29 Un proceso para preparar derivados de tetrahidroquinolina

Country Status (10)

Country Link
US (1) US8084611B2 (es)
EP (2) EP2007728B1 (es)
JP (1) JP5275971B2 (es)
AR (1) AR060174A1 (es)
AT (1) ATE533747T1 (es)
ES (1) ES2374315T3 (es)
PE (1) PE20071150A1 (es)
TW (1) TW200808731A (es)
UY (1) UY30244A1 (es)
WO (1) WO2007116922A1 (es)

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TW202416994A (zh) 2022-08-22 2024-05-01 荷蘭商新阿姆斯特丹製藥公司 固定劑量醫藥組合物及其用途
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WO2025059594A1 (en) 2023-09-15 2025-03-20 Newamsterdam Pharma B.V. METHODS FOR TREATING HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HeFH)
WO2025093436A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor
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Also Published As

Publication number Publication date
TW200808731A (en) 2008-02-16
US8084611B2 (en) 2011-12-27
EP2154132A1 (en) 2010-02-17
JP5275971B2 (ja) 2013-08-28
ES2374315T3 (es) 2012-02-15
WO2007116922A1 (en) 2007-10-18
AR060174A1 (es) 2008-05-28
JP2009532345A (ja) 2009-09-10
US20090292125A1 (en) 2009-11-26
EP2007728A1 (en) 2008-12-31
ATE533747T1 (de) 2011-12-15
EP2007728B1 (en) 2011-11-16
UY30244A1 (es) 2007-11-30

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