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PE20071111A1 - Metodos para modular el contenido de manosa de proteinas recombinantes - Google Patents

Metodos para modular el contenido de manosa de proteinas recombinantes

Info

Publication number
PE20071111A1
PE20071111A1 PE2007000069A PE2007000069A PE20071111A1 PE 20071111 A1 PE20071111 A1 PE 20071111A1 PE 2007000069 A PE2007000069 A PE 2007000069A PE 2007000069 A PE2007000069 A PE 2007000069A PE 20071111 A1 PE20071111 A1 PE 20071111A1
Authority
PE
Peru
Prior art keywords
fragment
antibody
recombinant
same
mannose content
Prior art date
Application number
PE2007000069A
Other languages
English (en)
Inventor
Jian Wu
Nicole Le
La Cruz Michael De
Gregory Flynn
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38266667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071111(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20071111A1 publication Critical patent/PE20071111A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
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Abstract

REFERIDA A UN METODO PARA PRODUCIR UNA GLICOPROTEINA RECOMBINANTE CON BAJO CONTENIDO DE MANOSA, UN ANTICUERPO MONOCLONAL HUMANO RECOMBINANTE O FRAGMENTO DE FIJACION AL ANTIGENO DEL MISMO CON BAJO CONTENIDO DE MANOSA O UN ANTICUERPO MONOCLONAL HUMANO RECOMBINANTE O FRAGMENTO DE FIJACION DEL ANTIGENO DEL MISMO QUE ENLAZA IL-15 CON BAJO CONTENIDO DE MANOSA, DONDE DICHO METODO CONSISTE EN EL CULTIVO DE UNA CELULA HUESPED QUE EXPRESA LA GLICOPROTEINA RECOMBINANTE O EL ANTICUERPO RECOMBINANTE O FRAGMENTO DE FIJACION AL ANTIGENO DEL MISMO, EN UN MEDIO DE CULTIVO QUE TIENE UNA OSMOLALIDAD DE 600 MOSM/KG O MENOS. EL MEDIO DE CULTIVO ESTA COMPUESTO DE: SALES DE POTASIO O DE SODIO; UNA O MAS VITAMINAS TALES COMO BIOTINA, PANTOTENATO, NIACINAMIDA, ENTRE OTRAS; GLUCOSA; PEPTONAS TALES COMO PEPTONA DE SOYA, PEPTONA DE TRIGO, ENTRE OTRAS; UN OSMOPROTECTOR TAL COMO BETAINA, L-PROLINA, L-TREONINA, ENTRE OTROS
PE2007000069A 2006-01-23 2007-01-22 Metodos para modular el contenido de manosa de proteinas recombinantes PE20071111A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76147706P 2006-01-23 2006-01-23
US11/644,345 US20070190057A1 (en) 2006-01-23 2006-12-22 Methods for modulating mannose content of recombinant proteins

Publications (1)

Publication Number Publication Date
PE20071111A1 true PE20071111A1 (es) 2007-11-19

Family

ID=38266667

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000069A PE20071111A1 (es) 2006-01-23 2007-01-22 Metodos para modular el contenido de manosa de proteinas recombinantes

Country Status (17)

Country Link
US (5) US20070190057A1 (es)
EP (1) EP1984517B2 (es)
JP (1) JP5133261B2 (es)
KR (2) KR20130012589A (es)
AU (1) AU2007208274C1 (es)
BR (1) BRPI0707529A2 (es)
CA (1) CA2637156C (es)
DK (1) DK1984517T3 (es)
EA (1) EA016153B1 (es)
ES (1) ES2391656T5 (es)
IL (1) IL192981A0 (es)
PE (1) PE20071111A1 (es)
PL (1) PL1984517T3 (es)
PT (1) PT1984517E (es)
SI (1) SI1984517T2 (es)
TW (1) TWI408146B (es)
WO (1) WO2007087384A2 (es)

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