PE20071029A1 - Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides - Google Patents
Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloidesInfo
- Publication number
- PE20071029A1 PE20071029A1 PE2006001479A PE2006001479A PE20071029A1 PE 20071029 A1 PE20071029 A1 PE 20071029A1 PE 2006001479 A PE2006001479 A PE 2006001479A PE 2006001479 A PE2006001479 A PE 2006001479A PE 20071029 A1 PE20071029 A1 PE 20071029A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- inhibitors
- cyane
- benzyliden
- metoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 3,4,5-TRIFLUOROPHENYL Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical class [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UN COMPUESTO CINAMIDA DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O UN ENLACE DOBLE; Ar1 ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDOS CON HALOGENO, HIDROXILO, CIANO, CICLOALQUILO C3-C8, ENTRE OTROS; R1 Y R2 SON HALOGENO, CIANO, OH, CICLOALQUILO C3-C8, CICLOALCOXI C3-C8, ENTRE OTROS; Z1 ES METILENO O VIVNILENO OPCIONALMENTE SUSTITUIDOS CON HALO, CIANO, OH, CICLOALQUILO C3-C8, ENTRE OTROS; p, q Y r SON UN NUMERO ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: (E)-(3S)-(3,4,5-TRIFLUOROFENIL)-6-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]-(9R)-HEXAHIDROINDOLIZIN-5-ONA, (E)-(3S)-(3,4-DIFLUOROFENIL)-6-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]-(9R)-HEXAHIDROINDOLIZIN-5-ONA, (E)-(6R,9aS)-6-(4-FLUOROFENIL)-3-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-1-IL)-BENCILIDEN]OCTAHIDROQUINOLIZIN-4-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PRODUCCION DE BETA AMILOIDE Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS TALES COMO LA ENFERMEDAD DE ALZHEIMER Y EL SINDROME DE DOWN
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005337963 | 2005-11-24 | ||
| JP2006205538 | 2006-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071029A1 true PE20071029A1 (es) | 2007-11-17 |
Family
ID=38067057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001479A PE20071029A1 (es) | 2005-11-24 | 2006-11-21 | Compuestos de cinamida no peptidicos biciclicos como inhibidores de beta amiloides |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8048878B2 (es) |
| EP (1) | EP1953158B1 (es) |
| JP (1) | JP5178203B2 (es) |
| KR (1) | KR101296239B1 (es) |
| AR (1) | AR057915A1 (es) |
| AU (1) | AU2006317468B2 (es) |
| BR (1) | BRPI0618890A2 (es) |
| CA (1) | CA2629512C (es) |
| CR (1) | CR9983A (es) |
| EA (1) | EA014427B1 (es) |
| EC (1) | ECSP088466A (es) |
| ES (1) | ES2394364T3 (es) |
| GE (1) | GEP20115172B (es) |
| HN (1) | HN2008000792A (es) |
| MA (1) | MA29968B1 (es) |
| ME (1) | ME00040B (es) |
| MY (1) | MY144596A (es) |
| NO (1) | NO20082805L (es) |
| NZ (1) | NZ568422A (es) |
| PE (1) | PE20071029A1 (es) |
| PL (1) | PL1953158T3 (es) |
| RS (1) | RS20080242A (es) |
| SA (1) | SA06270432B1 (es) |
| TW (1) | TWI370130B (es) |
| WO (1) | WO2007060821A1 (es) |
Families Citing this family (28)
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|---|---|---|---|---|
| EP1757591A4 (en) * | 2004-05-26 | 2010-05-05 | Eisai R&D Man Co Ltd | ZIMTSÄUREAMIDVERBINDUNG |
| CN100577657C (zh) | 2004-10-26 | 2010-01-06 | 卫材R&D管理有限公司 | 肉桂酰胺化合物的无定形物 |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| MY144960A (en) | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| AR062095A1 (es) | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
| TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| EP2152695A2 (en) * | 2007-06-01 | 2010-02-17 | Schering Corporation | Gamma secretase modulators |
| JP5121346B2 (ja) * | 2007-08-07 | 2013-01-16 | 国立大学法人 長崎大学 | 光学活性プロリンエステル誘導体およびｎ−ホルミル光学活性プロリン誘導体の製造方法 |
| MY150507A (en) | 2007-08-31 | 2014-01-30 | Eisai R&D Man Co Ltd | Polycyclic compound |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| JPWO2009081959A1 (ja) * | 2007-12-26 | 2011-05-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ４−（置換フェニル）ヘキサヒドロピリド［２，１−ｃ］［１，４］オキサジン−６−オンの製造方法 |
| MX2010008700A (es) | 2008-02-22 | 2010-08-30 | Hoffmann La Roche | Moduladores de beta-amiloide. |
| EP2334665B1 (en) | 2008-10-09 | 2013-07-10 | F. Hoffmann-La Roche AG | Modulators for amyloid beta |
| US20110263529A1 (en) * | 2008-11-06 | 2011-10-27 | Ruo Xu | Gamma secretase modulators |
| AU2009313527A1 (en) * | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| CN102209537A (zh) | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| CA2749702A1 (en) | 2009-02-26 | 2010-09-02 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
| US8754100B2 (en) | 2009-02-26 | 2014-06-17 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| JP2012176901A (ja) | 2009-09-25 | 2012-09-13 | Eisai R & D Management Co Ltd | 新規ベンゾニトリル化合物およびその製造方法 |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| KR20130121076A (ko) * | 2010-06-15 | 2013-11-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Ｈｃｖ 감염증 치료제 |
| JP6095208B2 (ja) * | 2012-12-04 | 2017-03-15 | 学校法人慶應義塾 | 環化化合物の製造方法、及び、環化化合物を含有する溶液の発光方法 |
| RS63203B1 (sr) * | 2016-12-09 | 2022-06-30 | Denali Therapeutics Inc | Jedinjenja korisna kao inhibitori ripk1 |
| MX2019013642A (es) * | 2017-05-17 | 2020-07-20 | Denali Therapeutics Inc | Compuestos, composiciones y metodos. |
| US20230049231A1 (en) * | 2019-10-07 | 2023-02-16 | D. E. Shaw Research, Llc | ARYL HETEROBICYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS |
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-
2006
- 2006-10-27 TW TW095139718A patent/TWI370130B/zh not_active IP Right Cessation
- 2006-11-01 PL PL06822806T patent/PL1953158T3/pl unknown
- 2006-11-01 EP EP06822806A patent/EP1953158B1/en active Active
- 2006-11-01 KR KR1020087014992A patent/KR101296239B1/ko not_active Expired - Fee Related
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