PE20070376A1 - METALLIC COMPLEXES WITH PERFLUOROALKYL CONTENT AND PROCEDURES FOR THEIR PREPARATION - Google Patents
METALLIC COMPLEXES WITH PERFLUOROALKYL CONTENT AND PROCEDURES FOR THEIR PREPARATIONInfo
- Publication number
- PE20070376A1 PE20070376A1 PE2006000844A PE2006000844A PE20070376A1 PE 20070376 A1 PE20070376 A1 PE 20070376A1 PE 2006000844 A PE2006000844 A PE 2006000844A PE 2006000844 A PE2006000844 A PE 2006000844A PE 20070376 A1 PE20070376 A1 PE 20070376A1
- Authority
- PE
- Peru
- Prior art keywords
- integer
- sigma
- radical
- metallic
- joint site
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 150000003254 radicals Chemical group 0.000 abstract 4
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000001455 metallic ions Chemical class 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical group CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDA A UN COMPLEJO CON CONTENIDO DE PERFLUOROALQUILO DE FORMULA (I), DONDE R ES UN RADICAL MONO- U OLIGOSACARIDO UNIDO A TRAVES DE UN OH; Q ES SIGMA-CO-(CH2)n''-E, SIGMA-NH-(CH2)n''-E, SIGMA-(CH2)m-E, DONDE n'' ES UN ENTERO DE 1 Y 5, m ES UN ENTERO DE 1 Y 6, DONDE SIGMA INDICA EL ITIO DE UNION CON EL LIGADOR Y E INDICA EL SITIO DE UNION CON EL RADICAL R; K ES UN COMPLEJO METALICO DE FORMULA II, III, IV, ENTRE OTROS, DONDE R1 ES H O UNEQUIVALENTE DE IONES METALICOS DE LOS NUMEROS ATOMICOS 21-29, 31-33, 37-39, 42-44, 49 O 57-83; R2 Y R3 SON H, ALQUILO C1-C7, BENCILO, ENTRE OTROS; U ES FENILENO, ALQUILENO C1-C12, ENTRE OTROS; R4 ES H O UN EQUIVALENTE METALICO TAL COMO EN R1; U1 ES -(CH2)p, ENTRE OTROS; p ES UN ENTERO ENTRE 1 Y 4; L ES UN GRUPO IXa) A IXb), DONDE n' Y m' SON UN ENTERO ENTRE 0 Y 4 Y m'+n' SON MAYOR O IGUAL A 1, R8 Y R8' SON H U OH; W ES O, FENILENO, ENLACE DIRECTO, ENTRE OTROS; q' ES UN ENTERO ENTRE 1 Y 4; ALFA ES EL SITIO DE UNION DE L CON EL COMPLEJO K, BETA ES EL SITIO DE UNION DE L CON EL RADICAL Q Y GAMMA ES EL SITIO DE UNION DE L CON EL RADICAL X; X ES UN GRUPO DE FORMULA VI, DONDE Y ES ENLACE DIRECTO, CO O NR6; R6 ES H O UNA CADENA DE CARBONOS C1-C15 LINEAL O RAMIFICADA, ENTRE OTROS; G ES O O SO2; s Y s' SON 1 O 2; t ES 0 O 1; p ES EL SITIO DE UNION DE X CON L Y E ES EL SITIO DE UNION DE X CON Rf. DICHO COMPLEJO METALICO ES UTIL EN EL DIAGNOSTICO POR RMN Y RAYOS X, EN EL RADIODIAGNOSTICO Y RADIOTERAPIAREFERRED TO A COMPLEX WITH PERFLUOROALKYL CONTENT OF FORMULA (I), WHERE R IS A RADICAL MONO- OR OLIGOSACARIDO JOINED THROUGH AN OH; Q IS SIGMA-CO- (CH2) n '' - E, SIGMA-NH- (CH2) n '' - E, SIGMA- (CH2) mE, WHERE n '' IS AN INTEGER OF 1 AND 5, m IS A INTEGRAL OF 1 AND 6, WHERE SIGMA INDICATES THE ITIO OF UNION WITH THE LIGATOR AND AND INDICATES THE SITE OF UNION WITH THE RADICAL R; K IS A METALLIC COMPLEX OF FORMULA II, III, IV, AMONG OTHERS, WHERE R1 IS H OR ANEQUIVALENT OF METALLIC IONS OF ATOMIC NUMBERS 21-29, 31-33, 37-39, 42-44, 49 OR 57-83; R2 AND R3 ARE H, C1-C7 ALKYL, BENZYL, AMONG OTHERS; U IS PHENYLENE, C1-C12 ALKYLENE, AMONG OTHERS; R4 IS H OR A METALLIC EQUIVALENT SUCH AS R1; U1 IS - (CH2) p, AMONG OTHERS; p IS AN INTEGER BETWEEN 1 AND 4; L IS A GROUP IXa) TO IXb), WHERE n 'AND m' ARE AN INTEGER BETWEEN 0 AND 4 AND m '+ n' ARE GREATER OR EQUAL TO 1, R8 AND R8 'ARE H U OH; W ES O, FENILENO, DIRECT LINK, AMONG OTHERS; q 'IS AN INTEGER BETWEEN 1 AND 4; ALPHA IS THE JOINT SITE OF L WITH THE K COMPLEX, BETA IS THE JOINT SITE OF L WITH THE RADICAL Q AND GAMMA IS THE JOINT SITE OF L WITH THE RADICAL X; X IS A GROUP OF FORMULA VI, WHERE Y IS A DIRECT LINK, CO OR NR6; R6 IS H OR A LINEAR OR BRANCHED C1-C15 CARBON CHAIN, AMONG OTHERS; G IS O O SO2; s AND s' ARE 1 O 2; t IS 0 O 1; p IS THE JOINT SITE OF X WITH L AND E IS THE JOINT SITE OF X WITH Rf. SAID METALLIC COMPLEX IS USEFUL IN DIAGNOSIS BY NMR AND X-RAYS, IN RADIODIAGNOSIS AND RADIOTHERAPY
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005033902A DE102005033902B3 (en) | 2005-07-15 | 2005-07-15 | Perfluoroalkyl-containing complexes, processes for their preparation, and their use and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070376A1 true PE20070376A1 (en) | 2007-04-20 |
Family
ID=37057146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000844A PE20070376A1 (en) | 2005-07-15 | 2006-07-14 | METALLIC COMPLEXES WITH PERFLUOROALKYL CONTENT AND PROCEDURES FOR THEIR PREPARATION |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1904463A2 (en) |
| JP (1) | JP2009501174A (en) |
| KR (1) | KR20080043762A (en) |
| CN (1) | CN101223148A (en) |
| AR (1) | AR054865A1 (en) |
| AU (1) | AU2006272025A1 (en) |
| BR (1) | BRPI0613407A2 (en) |
| CA (1) | CA2615443A1 (en) |
| CR (1) | CR9645A (en) |
| DE (1) | DE102005033902B3 (en) |
| DO (1) | DOP2006000167A (en) |
| EC (1) | ECSP088100A (en) |
| GT (1) | GT200600313A (en) |
| IL (1) | IL187926A0 (en) |
| NO (1) | NO20080813L (en) |
| PE (1) | PE20070376A1 (en) |
| RU (1) | RU2008105356A (en) |
| TN (1) | TNSN08016A1 (en) |
| TW (1) | TW200706538A (en) |
| UY (1) | UY29664A1 (en) |
| WO (1) | WO2007009638A2 (en) |
| ZA (1) | ZA200801523B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007015598A1 (en) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Use of fluorochemical compounds for diagnostic purposes using imaging techniques |
| KR101595324B1 (en) | 2008-01-08 | 2016-02-18 | 랜티우스 메디컬 이메징, 인크. | N-alkoxyamide conjugates as imaging agents |
| CA3153519A1 (en) * | 2019-10-04 | 2021-04-08 | Bryan J. Traughber | Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters |
| EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
| CN114181164A (en) * | 2021-12-13 | 2022-03-15 | 武汉大学中南医院 | Synthesis method and application of MRI contrast agent based on Fe (II) specificity |
| EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
| EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4317588C2 (en) * | 1993-05-24 | 1998-04-16 | Schering Ag | Macrocyclic metal complexes containing fluorine, process for their preparation and their use |
| DE19603033A1 (en) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoroalkyl-containing metal complexes, processes for their preparation and their use in NMR diagnostics |
| DE19744003B4 (en) * | 1997-09-26 | 2004-07-08 | Schering Ag | Contrast agent for infarct and necrosis imaging |
| DE19744004C1 (en) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophilic metal complexes for necrosis and infarct imaging |
| DE19914101C1 (en) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoroalkylamides, their preparation and their use in diagnostics |
| DE10040858C2 (en) * | 2000-08-11 | 2003-12-18 | Schering Ag | Perfluoroalkyl-containing complexes with polar residues, process for their preparation and their use |
-
2005
- 2005-07-15 DE DE102005033902A patent/DE102005033902B3/en not_active Expired - Fee Related
-
2006
- 2006-07-11 BR BRPI0613407-6A patent/BRPI0613407A2/en not_active Application Discontinuation
- 2006-07-11 RU RU2008105356/04A patent/RU2008105356A/en not_active Application Discontinuation
- 2006-07-11 UY UY29664A patent/UY29664A1/en not_active Application Discontinuation
- 2006-07-11 AU AU2006272025A patent/AU2006272025A1/en not_active Abandoned
- 2006-07-11 CN CNA2006800258905A patent/CN101223148A/en active Pending
- 2006-07-11 WO PCT/EP2006/006777 patent/WO2007009638A2/en not_active Ceased
- 2006-07-11 KR KR1020087001084A patent/KR20080043762A/en not_active Withdrawn
- 2006-07-11 EP EP06791535A patent/EP1904463A2/en not_active Withdrawn
- 2006-07-11 JP JP2008520780A patent/JP2009501174A/en not_active Withdrawn
- 2006-07-11 CA CA002615443A patent/CA2615443A1/en not_active Abandoned
- 2006-07-13 DO DO2006000167A patent/DOP2006000167A/en unknown
- 2006-07-14 TW TW095125755A patent/TW200706538A/en unknown
- 2006-07-14 PE PE2006000844A patent/PE20070376A1/en not_active Application Discontinuation
- 2006-07-14 GT GT200600313A patent/GT200600313A/en unknown
- 2006-07-14 AR ARP060103020A patent/AR054865A1/en unknown
-
2007
- 2007-12-06 IL IL187926A patent/IL187926A0/en unknown
-
2008
- 2008-01-08 CR CR9645A patent/CR9645A/en unknown
- 2008-01-11 EC EC2008008100A patent/ECSP088100A/en unknown
- 2008-01-14 TN TNP2008000016A patent/TNSN08016A1/en unknown
- 2008-02-14 NO NO20080813A patent/NO20080813L/en not_active Application Discontinuation
- 2008-02-14 ZA ZA200801523A patent/ZA200801523B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL187926A0 (en) | 2008-03-20 |
| CN101223148A (en) | 2008-07-16 |
| WO2007009638A2 (en) | 2007-01-25 |
| BRPI0613407A2 (en) | 2011-01-11 |
| DOP2006000167A (en) | 2007-02-28 |
| KR20080043762A (en) | 2008-05-19 |
| ZA200801523B (en) | 2008-11-26 |
| ECSP088100A (en) | 2008-05-30 |
| UY29664A1 (en) | 2007-02-28 |
| TW200706538A (en) | 2007-02-16 |
| CR9645A (en) | 2008-05-21 |
| NO20080813L (en) | 2008-04-09 |
| RU2008105356A (en) | 2009-08-20 |
| AU2006272025A1 (en) | 2007-01-25 |
| CA2615443A1 (en) | 2007-01-25 |
| TNSN08016A1 (en) | 2009-07-14 |
| AR054865A1 (en) | 2007-07-25 |
| JP2009501174A (en) | 2009-01-15 |
| GT200600313A (en) | 2007-04-23 |
| WO2007009638A3 (en) | 2007-04-26 |
| EP1904463A2 (en) | 2008-04-02 |
| DE102005033902B3 (en) | 2007-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |