[go: up one dir, main page]

PE20070124A1 - Derivados de heteroaril para tratar virus - Google Patents

Derivados de heteroaril para tratar virus

Info

Publication number
PE20070124A1
PE20070124A1 PE2006000725A PE2006000725A PE20070124A1 PE 20070124 A1 PE20070124 A1 PE 20070124A1 PE 2006000725 A PE2006000725 A PE 2006000725A PE 2006000725 A PE2006000725 A PE 2006000725A PE 20070124 A1 PE20070124 A1 PE 20070124A1
Authority
PE
Peru
Prior art keywords
heteroaril
substituted
derivatives
quinolin
pyrrol
Prior art date
Application number
PE2006000725A
Other languages
English (en)
Inventor
Franz Ulrich Schmitz
Janos Botyanszki
Christopher Don Roberts
Original Assignee
Genelabs Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Tech Inc filed Critical Genelabs Tech Inc
Publication of PE20070124A1 publication Critical patent/PE20070124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE L ES UN ENLACE, ALQUILENO C1-C3, ALQUENILENO C2-C3 SUSTITUIDO, CICLOALQUILENO C3-C6, ENTRE OTROS; UNO DE X, X' ESNR1 Y EL OTRO ES SELECCIONADO ENTRE CR2, N, O, S; Q ES CR, N, O, S; R ES H, HALO, ALQUIL C1-C2, ALQUENIL C2-C3, ENTRE OTROS; R1 Y R2 SON CADA UNO H, ALQUIL, ALQUIL SUSTITUIDO, CICLOALQUIL SUSTITUIDO, ALQUINIL, ENTRE OTROS; Z ES H, HALO, ALQUIL, ALQUENIL, ALCOXI, ARIL, CIANO, HETEROARIL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: SINTESIS DE ACIDO 1-CARBOXIMETIL-4-CICLOHEXIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-1H-PIRROL-2-CARBOXILICO; ACIDO TERT-BUTOXICARBONILMETIL-4-CICLOHEXIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-1H-PIRROL-2-CARBOXILICO; ENTRE OTROS. REFERIDA TEMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INFECCIONES VIRALES EN AMIMALES MEDIADOS POR EL VIRUS FLAVIVIRIDAE
PE2006000725A 2005-06-24 2006-06-23 Derivados de heteroaril para tratar virus PE20070124A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69370005P 2005-06-24 2005-06-24

Publications (1)

Publication Number Publication Date
PE20070124A1 true PE20070124A1 (es) 2007-03-09

Family

ID=37499598

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000725A PE20070124A1 (es) 2005-06-24 2006-06-23 Derivados de heteroaril para tratar virus

Country Status (14)

Country Link
US (1) US20060293320A1 (es)
EP (1) EP1910337A2 (es)
JP (1) JP2008546802A (es)
KR (1) KR20080040677A (es)
CN (1) CN101223161A (es)
AR (1) AR054797A1 (es)
AU (1) AU2006261132A1 (es)
BR (1) BRPI0612124A2 (es)
CA (1) CA2613261A1 (es)
MA (1) MA28394B1 (es)
MX (1) MX2007016144A (es)
PE (1) PE20070124A1 (es)
TW (1) TW200726471A (es)
WO (1) WO2006138744A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2644933A1 (en) * 2006-02-27 2007-09-07 Gilead Colorado, Inc. Combinations comprising a histone deacetylase inhibiting agent and a nuclear hormone receptor ligand for treating cardiovascular conditions
UY30892A1 (es) * 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP2494991A1 (en) 2007-05-04 2012-09-05 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of HCV infection
US20090005374A1 (en) * 2007-06-26 2009-01-01 Melvin Jr Lawrence S Imidazopyridinyl thiazolyl histone deacetylase inhibitors
WO2010009166A1 (en) * 2008-07-14 2010-01-21 Gilead Colorado, Inc. Oxindolyl inhibitor compounds
US8134000B2 (en) * 2008-07-14 2012-03-13 Gilead Sciences, Inc. Imidazolyl pyrimidine inhibitor compounds
NZ590320A (en) * 2008-07-14 2012-12-21 Gilead Sciences Inc Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
CA2731323A1 (en) * 2008-07-28 2010-02-04 Gilead Sciences, Inc. Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
DK2318007T3 (da) * 2008-08-15 2013-03-25 N30 Pharmaceuticals Inc Nye pyrrol-inhibitorer af s-nitrosoglutathion-reduktase som terapeutiske midler
JP5524209B2 (ja) 2008-08-15 2014-06-18 エヌサーティー・ファーマシューティカルズ・インコーポレーテッド Ｓ−ニトロソグルタチオンレダクターゼのピロール阻害剤
DK2315591T3 (en) 2008-08-15 2016-06-06 Nivalis Therapeutics Inc NOVEL PYRROLE INHIBITORS OF S-nitrosoglutathione-reductase as therapeutic agents
CN102405047B (zh) 2009-01-30 2014-07-09 葛兰素史密斯克莱有限责任公司 结晶型的n-{(1s)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1h-吡唑-5-基)-2-噻吩甲酰胺盐酸盐
WO2010144371A1 (en) * 2009-06-08 2010-12-16 Gilead Colorado, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
AU2010259042A1 (en) * 2009-06-08 2011-12-15 Gilead Sciences, Inc. Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds
PL2455376T3 (pl) * 2009-06-11 2015-06-30 Abbvie Bahamas Ltd Związki heterocykliczne jako inhibitory wirusa zapalenia wątroby typu C (HCV)
US8822515B2 (en) 2009-10-16 2014-09-02 University Of Maryland, Baltimore County Heterocyclic benzoxazole compositions as inhibitors of hepatitis C virus
CA2779244A1 (en) 2009-10-30 2011-05-05 Boehringer Ingelheim International Gmbh Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
TWI508968B (zh) * 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
CA2813093A1 (en) * 2010-09-30 2012-04-05 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
EP1304335B1 (en) * 1990-04-04 2009-06-10 Novartis Vaccines and Diagnostics, Inc. Hepatitis C virus protease
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5738985A (en) * 1993-04-02 1998-04-14 Ribogene, Inc. Method for selective inactivation of viral replication
IT1272179B (it) * 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv.
US5861267A (en) * 1995-05-01 1999-01-19 Vertex Pharmaceuticals Incorporated Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
US5759795A (en) * 1996-03-08 1998-06-02 Schering Corporation Assay for determining inhibitors of ATPase
WO1998039487A1 (en) * 1997-03-05 1998-09-11 Ribogene, Inc. Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication
US6228576B1 (en) * 1997-12-11 2001-05-08 Smithkline Beecham Corporation Hepatitis C virus NS5B truncated protein and methods thereof to identify antiviral compounds
CO5271680A1 (es) * 2000-02-21 2003-04-30 Smithkline Beecham Corp Compuestos
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
MY151199A (en) * 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
PL375442A1 (en) * 2002-07-18 2005-11-28 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
GB0307891D0 (en) * 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
EP1651631A1 (en) * 2003-08-01 2006-05-03 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae

Also Published As

Publication number Publication date
CA2613261A1 (en) 2006-12-28
KR20080040677A (ko) 2008-05-08
JP2008546802A (ja) 2008-12-25
WO2006138744A3 (en) 2007-04-05
TW200726471A (en) 2007-07-16
WO2006138744A2 (en) 2006-12-28
BRPI0612124A2 (pt) 2010-10-19
EP1910337A2 (en) 2008-04-16
AR054797A1 (es) 2007-07-18
AU2006261132A1 (en) 2006-12-28
CN101223161A (zh) 2008-07-16
MA28394B1 (fr) 2007-01-02
MX2007016144A (es) 2008-03-06
US20060293320A1 (en) 2006-12-28

Similar Documents

Publication Publication Date Title
PE20070124A1 (es) Derivados de heteroaril para tratar virus
PE20090630A1 (es) Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion
PE20120666A1 (es) Inhibidores de los virus flaviviridae
PE20071136A1 (es) Derivados de anilina sustituida como antagonistas de la histamina h3
TW200730478A (en) N-(6-membered aromatic ring)-amido anti-viral compounds
PE20080992A1 (es) Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c
AR074608A1 (es) Derivados de 2-(piperidin-1-il)-4-heterociclil-tiazol-5-carboxilico para infecciones bacterianas
PE20130311A1 (es) Composiciones y metodos para modular la via de senalizacion de wnt
PE20121479A1 (es) Inhibidores del virus de la hepatitis c
CL2004001161A1 (es) Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c.
DK1295890T3 (da) Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge
PE20080906A1 (es) Derivados heteroarilo como inhibidores de citocina
AP1753A (en) Thiophene derivatives as antiviral agents for flavvivirus infection
TNSN07252A1 (en) Indole derivatives for treating viral infections
MX2007004979A (es) Derivados de indol tetraciclicos como agentes antiviricos.
AR054560A1 (es) Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer
TW200730476A (en) N-(5-membered aromatic ring)-amido anti-viral compounds
TW200720285A (en) Nucleoside compounds for treating viral infections
ECSP099319A (es) Analogos de tiofeno para el tratamiento o prevencion de las infecciones por flavivirus
AR057954A1 (es) Compuestos derivados de acido tartarico, composiciones farmaceuticas que los contienen y usos como agentes antimicrobianos.
BRPI0514425A (pt) inibidores de rna polimerase dependente de rna do vìrus da hepatite c, e composições e tratamentos usando os mesmos
EA201100482A1 (ru) Кристаллические формы 2-тиазолил-4-хинолинилоксипроизводного, активного ингибитора hcv
PE20080427A1 (es) Agentes antivirales
PE20220252A1 (es) Compuestos de pirrol
PE20081113A1 (es) Inhibidores virales policiclicos

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed