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PE20070103A1 - Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona - Google Patents

Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona

Info

Publication number
PE20070103A1
PE20070103A1 PE2006000772A PE2006000772A PE20070103A1 PE 20070103 A1 PE20070103 A1 PE 20070103A1 PE 2006000772 A PE2006000772 A PE 2006000772A PE 2006000772 A PE2006000772 A PE 2006000772A PE 20070103 A1 PE20070103 A1 PE 20070103A1
Authority
PE
Peru
Prior art keywords
formula
diona
isoindoline
amino
cycling
Prior art date
Application number
PE2006000772A
Other languages
English (en)
Inventor
George W Muller
Manohar T Saindane
Roger S Chen
Chuansheng Ge
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37305020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070103(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of PE20070103A1 publication Critical patent/PE20070103A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

REFERIDA A UN PROCESO PARA PREPARAR UN COMPUESTO 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-IL)ISOINDOLINA-1,3-DIONA DE FORMULA (I), DONDE DICHO PROCESO COMPRENDE CICLAR UN COMPUESTO N-(3-AMINOFTALOIL)-GLUTAMINA DE FORMULA (II) O UN COMPUESTO N-(3-AMINOFTALOIL)-ISOGLUTAMINA DE FORMULA (IIA) CON UN AGENTE CICLIZANTE Y-C(=O)-X (FORMULA V), DONDE R1 ES H. F, BENCILO, ALQUILO C1-C8, ALQUENILO C2-C8 O ALQUINILO C2-C8; X E Y SON IMIDAZOLILO, BENCIMIDAZOLILO O BENZOTRIAZOLILO NO SUSTITUIDO O SUSTITUIDO. DICHA CICLIZACION SE LLEVA A CABO EN UN SOLVENTE SELECCIONADO DE ACETONITRILO O N-METIL PIRROLIDINA, A UNA TEMPERATURA DE ENTRE 80 ºC Y 87 ºC POR UN TIEMPO DE REACCION DE ENTRE 1 A 5 HORAS. DICHOS COMPUESTOS DE FORMULA (I) REDUCEN LOS NIVELES O LA ACTIVIDAD DEL FACTOR ALFA DE NECROSIS TUMORAL (TNF-ALFA) Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS A UN ALTO NIVEL DE ANORMALIDAD O ACTIVIDAD DE TNF-ALFA
PE2006000772A 2005-06-30 2006-07-03 Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona PE20070103A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69622405P 2005-06-30 2005-06-30

Publications (1)

Publication Number Publication Date
PE20070103A1 true PE20070103A1 (es) 2007-02-06

Family

ID=37305020

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2009001183A PE20100151A1 (es) 2005-06-30 2006-07-03 Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona
PE2006000772A PE20070103A1 (es) 2005-06-30 2006-07-03 Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2009001183A PE20100151A1 (es) 2005-06-30 2006-07-03 Procesos para la preparacion de compuestos de 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona

Country Status (24)

Country Link
US (5) US7994327B2 (es)
EP (2) EP2380887B1 (es)
JP (2) JP5366544B2 (es)
KR (2) KR101342241B1 (es)
CN (2) CN102643267B (es)
AU (1) AU2006265019B2 (es)
BR (1) BRPI0612803A2 (es)
CA (2) CA2612612C (es)
CR (1) CR9697A (es)
DK (2) DK1907373T3 (es)
EC (1) ECSP088154A (es)
ES (2) ES2430545T3 (es)
HR (2) HRP20130102T1 (es)
IL (2) IL188330A (es)
ME (1) ME01513B (es)
MX (1) MX2007016290A (es)
NZ (1) NZ565309A (es)
PE (2) PE20100151A1 (es)
PL (2) PL1907373T3 (es)
PT (2) PT1907373E (es)
RS (2) RS53030B (es)
SI (2) SI2380887T1 (es)
WO (1) WO2007005972A1 (es)
ZA (1) ZA200800828B (es)

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