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PE20070465A1 - Tinturas de indocarbocianina para el diagnostico de artritis reumatoide por imagenes opticas - Google Patents

Tinturas de indocarbocianina para el diagnostico de artritis reumatoide por imagenes opticas

Info

Publication number
PE20070465A1
PE20070465A1 PE2006000766A PE2006000766A PE20070465A1 PE 20070465 A1 PE20070465 A1 PE 20070465A1 PE 2006000766 A PE2006000766 A PE 2006000766A PE 2006000766 A PE2006000766 A PE 2006000766A PE 20070465 A1 PE20070465 A1 PE 20070465A1
Authority
PE
Peru
Prior art keywords
indocarbocyanine
diagnosis
rheumatoid arthritis
stains
optical images
Prior art date
Application number
PE2006000766A
Other languages
English (en)
Inventor
Kai Licha
Michael Schirner
Sonja Vollmer
Axel Vater
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20070465A1 publication Critical patent/PE20070465A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4528—Joints
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

REFERIDA A UNA TINTURA DE INDOCARBOCIANINA DE FORMULA (I), DONDE C ES UN RADICAL DE FORMULA (II) O (III); LA POSICION QUE ESTA MARCADA CON ASTERISCO SIGNIFICA EL PUNTO DE UNION CON EL RADICAL A Y DONDE A ES UN GRUPO SELECCIONADO DE LAS FORMULAS =CH-CR5=CH- (IV), =CH-CH=CR5-CH=CH- (V), (VI), (VII) Y (VIII); R1 Y R2 SON SULFOALQUILO C1-C4, ALQUILO C1-C50, ENTRE OTROS; R3 ES UN CARBOHIDRATO LINEAL CON HASTA 20 RESIDUOS DE CARBONO, QUE ESTA SUSTITUIDA CON UNO O MAS GRUPOS OH, COOH, SO2, ENTRE OTROS; R5 ES H, F, Cl, bR, METILO, ENTRE OTROS; b ES 2 O 3; X E Y SON O, =C(CH3)2 O -(CH=CH)-. PREFERIBLEMENTE, LA TINTURA DE INDOCARBOCIANINA SE SELECCIONA DE Cy7, VERDE DE INDOCIANINA (ICG), ANALOGOS DE ICG E INDOTRICARBOCIANINA (ITC). DICHA TINTURA ES UTIL PARA EL DIAGNOSTICO DE ENFERMEDADES INFLAMATORIAS, EN PARTICULAR, ARTRITIS REUMATOIDE
PE2006000766A 2005-06-29 2006-07-03 Tinturas de indocarbocianina para el diagnostico de artritis reumatoide por imagenes opticas PE20070465A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69466905P 2005-06-29 2005-06-29
EP05015365A EP1743658A1 (en) 2005-07-14 2005-07-14 Optical imaging of rheumatoid arthritis

Publications (1)

Publication Number Publication Date
PE20070465A1 true PE20070465A1 (es) 2007-06-07

Family

ID=35276318

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000766A PE20070465A1 (es) 2005-06-29 2006-07-03 Tinturas de indocarbocianina para el diagnostico de artritis reumatoide por imagenes opticas

Country Status (15)

Country Link
US (2) US7879314B2 (es)
EP (3) EP1743658A1 (es)
AR (1) AR057420A1 (es)
AT (1) ATE537848T1 (es)
CA (1) CA2619034C (es)
DK (1) DK1931391T3 (es)
DO (1) DOP2006000155A (es)
ES (1) ES2379585T3 (es)
GT (1) GT200600286A (es)
PE (1) PE20070465A1 (es)
PL (1) PL1931391T3 (es)
SI (1) SI1931391T1 (es)
TW (1) TW200744643A (es)
UY (1) UY29642A1 (es)
WO (1) WO2007000349A2 (es)

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DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
EP1743658A1 (en) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis
US8750968B2 (en) * 2007-08-14 2014-06-10 Mivenion Gmbh Device and procedure for the diagnosis or diagnostic preparation and/or therapy monitoring of inflammatory diseases such as rheumatoid arthritis
US20090253990A1 (en) * 2007-12-06 2009-10-08 Children's Hospital Of Orange County Optical diagnosis of hemophilic joint effusion
CN102046072B (zh) * 2008-05-26 2013-04-24 阿克苏医学影像有限公司 光学检测方法和用于光学检测关节状况的设备
CN102196765A (zh) * 2008-10-27 2011-09-21 皇家飞利浦电子股份有限公司 用于光学检查身体部分的内部的设备和方法
WO2010064200A1 (en) * 2008-12-05 2010-06-10 Koninklijke Philips Electronics N.V. Method and device for optically examining the condition of joints
CN102238901B (zh) * 2008-12-05 2013-11-20 阿克苏医学影像有限公司 用于光学检测关节状况的光学检测方法和装置
EP2199208B1 (de) 2008-12-17 2012-08-01 Mettler-Toledo AG Dosiervorrichtung
GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
US9585972B2 (en) 2011-05-09 2017-03-07 Sherry L. Thornton Method for imaging a site of arthritis in an animal
CN103070670B (zh) * 2013-01-28 2014-11-12 厦门大学 一种早期骨性关节炎检测系统
EP3015069A1 (en) 2014-10-30 2016-05-04 Universitätsklinikum Jena Apparatus for suspended ultrasonography and corresponding method
JP6480769B2 (ja) * 2015-03-18 2019-03-13 キヤノン株式会社 撮影装置、撮影システム及び撮影装置で用いられる支持部材
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof

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CA2283949A1 (en) * 1997-03-13 1998-09-17 Haishan Zeng Methods and apparatus for detecting the rejection of transplanted tissue
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US20030064025A1 (en) * 2001-04-05 2003-04-03 Xiaoming Yang Imaging systems for in vivo protocols
US20030003048A1 (en) 2001-04-26 2003-01-02 Chun Li Diagnostic imaging compositions, their methods of synthesis and use
WO2003082988A1 (en) * 2002-03-29 2003-10-09 The General Hospital Corporation Nir-fluorescent cyanine dyes, their synthesis and biological use
WO2004028449A2 (en) 2002-09-24 2004-04-08 The General Hospital Corporation Azulene dimer-quenched, near-infrared fluorescent probes
WO2005019247A2 (en) 2003-08-15 2005-03-03 Board Of Regents, The University Of Texas System Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
US20080308744A1 (en) * 2003-11-18 2008-12-18 Beth Israel Deaconess Medical Center Serum Albumin Conjugated to Fluorescent Substances for Imaging
ATE374367T1 (de) * 2004-07-22 2007-10-15 Bayer Schering Pharma Ag Verwendung von cyanin-farbstoffen zur diagnose von krankheiten, welche mit angiogenese assoziert sind
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases
EP1743658A1 (en) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis

Also Published As

Publication number Publication date
AR057420A1 (es) 2007-12-05
EP1931391A2 (en) 2008-06-18
WO2007000349A2 (en) 2007-01-04
CA2619034A1 (en) 2007-01-04
EP1745739A2 (en) 2007-01-24
WO2007000349A3 (en) 2007-03-15
US7879314B2 (en) 2011-02-01
GT200600286A (es) 2007-03-14
DK1931391T3 (da) 2012-03-12
US20070059244A1 (en) 2007-03-15
ATE537848T1 (de) 2012-01-15
EP1743658A1 (en) 2007-01-17
US20110098578A1 (en) 2011-04-28
DOP2006000155A (es) 2007-11-30
CA2619034C (en) 2014-11-25
EP1745739A3 (en) 2009-04-22
UY29642A1 (es) 2007-01-31
ES2379585T3 (es) 2012-04-27
EP1931391B1 (en) 2011-12-21
TW200744643A (en) 2007-12-16
PL1931391T3 (pl) 2012-05-31
SI1931391T1 (sl) 2012-04-30

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