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PE20061167A1 - Composicion farmaceutica que comprende moduladores de fosfodiesterasa pde4 - Google Patents

Composicion farmaceutica que comprende moduladores de fosfodiesterasa pde4

Info

Publication number
PE20061167A1
PE20061167A1 PE2005001269A PE2005001269A PE20061167A1 PE 20061167 A1 PE20061167 A1 PE 20061167A1 PE 2005001269 A PE2005001269 A PE 2005001269A PE 2005001269 A PE2005001269 A PE 2005001269A PE 20061167 A1 PE20061167 A1 PE 20061167A1
Authority
PE
Peru
Prior art keywords
pharmaceutical composition
propionamide
composition including
phosphodiesterase pde4
phenyl
Prior art date
Application number
PE2005001269A
Other languages
English (en)
Inventor
Jerome B Zeldis
Herbert Faleck
Donald C Manning
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of PE20061167A1 publication Critical patent/PE20061167A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN MODULADOR DE FOSFODIESTERASA PDE4 TAL COMO 3-(3,4-DIMETOXI-FENILO)-3-(1-OXO-1,3-DIHIDRO-ISOINDOL-2-IL)-PROPIONAMIDA, 3-FENIL-2-(1-OXOISOINDOLIN-2-IL)PROPIONAMIDA, 3-(3-ETOXI-4METOXIFENIL)-N-HIDROXI-3-(1-OXOISOINDOLINIL)PROPIONAMIDA, ENTRE OTROS, CUYO RANGO DE DOSIS DIARIA ES DE 1mg A 10000mg POR DIA; B) UN AGENTE ACTIVO SECUNDARIO TAL COMO ANTIINFLAMATORIOS, ANTIHIPERTENSIVOS, ANTICONVULSIVANTES, BENZODIACEPINAS, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LESIONES DEL SISTEMA NERVIOSO CENTRAL TAL COMO LESION CEREBRAL FOCAL, LESION AXONAL DIFUSA, HEMATOMA SUBDURAL, EPILEPSIA POST TRAUMATICA
PE2005001269A 2004-10-28 2005-10-28 Composicion farmaceutica que comprende moduladores de fosfodiesterasa pde4 PE20061167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62380304P 2004-10-28 2004-10-28

Publications (1)

Publication Number Publication Date
PE20061167A1 true PE20061167A1 (es) 2006-11-08

Family

ID=36319648

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001269A PE20061167A1 (es) 2004-10-28 2005-10-28 Composicion farmaceutica que comprende moduladores de fosfodiesterasa pde4

Country Status (14)

Country Link
US (1) US20060106085A1 (es)
EP (1) EP1811992A2 (es)
JP (1) JP2008518924A (es)
KR (1) KR20070085454A (es)
CN (1) CN101309585A (es)
AR (1) AR052223A1 (es)
AU (1) AU2005302523A1 (es)
BR (1) BRPI0518062A (es)
CA (1) CA2585423A1 (es)
IL (1) IL182825A0 (es)
MX (1) MX2007005040A (es)
PE (1) PE20061167A1 (es)
WO (1) WO2006050057A2 (es)
ZA (1) ZA200704251B (es)

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AU2006304787A1 (en) * 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
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WO2009092432A1 (en) * 2008-01-24 2009-07-30 Merck Patent Gmbh Beta-amino acid derivatives for treatment of diabetes
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US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US10011611B2 (en) 2015-08-14 2018-07-03 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
EP3914701B1 (en) * 2019-01-23 2025-12-03 Path Therapeutics Inc. Methods of treating epilepsy via phosphodiesterase 4 b (pde4) inhibition
EP4281065A1 (en) * 2021-01-20 2023-11-29 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions
US11999694B2 (en) 2021-10-29 2024-06-04 Sensorium Therapeutics, Inc. Delivery of therapeutic alkaloid compounds
US12410128B1 (en) 2022-04-15 2025-09-09 Sensorium Therapeutics, Inc. Therapeutic alkaloid compounds

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Also Published As

Publication number Publication date
JP2008518924A (ja) 2008-06-05
US20060106085A1 (en) 2006-05-18
CN101309585A (zh) 2008-11-19
KR20070085454A (ko) 2007-08-27
AU2005302523A1 (en) 2006-05-11
IL182825A0 (en) 2007-09-20
AR052223A1 (es) 2007-03-07
WO2006050057A3 (en) 2008-07-10
ZA200704251B (en) 2008-11-26
EP1811992A2 (en) 2007-08-01
CA2585423A1 (en) 2006-05-11
MX2007005040A (es) 2007-06-19
WO2006050057A2 (en) 2006-05-11
BRPI0518062A (pt) 2008-10-28

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