[go: up one dir, main page]

PE20061161A1 - PHARMACEUTICAL COMPOSITION INCLUDING A STEROID - Google Patents

PHARMACEUTICAL COMPOSITION INCLUDING A STEROID

Info

Publication number
PE20061161A1
PE20061161A1 PE2005001407A PE2005001407A PE20061161A1 PE 20061161 A1 PE20061161 A1 PE 20061161A1 PE 2005001407 A PE2005001407 A PE 2005001407A PE 2005001407 A PE2005001407 A PE 2005001407A PE 20061161 A1 PE20061161 A1 PE 20061161A1
Authority
PE
Peru
Prior art keywords
steroid
alkyl
pharmaceutical composition
refers
composition including
Prior art date
Application number
PE2005001407A
Other languages
Spanish (es)
Inventor
Heinrich Kugelmann
Johannes Bartholomaus
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20061161A1 publication Critical patent/PE20061161A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A) UN COMPUESTO ESTEROIDE DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C6); R2 ES H O CO-ALQUILO(C1-C6); R3, R4, R5 Y R6 SON H, ALQUILO(C1-C6), ALQUENILO(C2-C6), ARILO(C5-C10), CN, ENTRE OTROS, TAL COMO ETINIL ESTRADIOL, DESOGESTREL, ENTRE OTROS; B) UN TENSIOACTIVO NO IONICO TAL COMO ALCOHOLES GRASOS, ESTEROLES, ESTERES DE SORBITANO DE ACIDO GRASO, GLICERIDO DE POLIOXIETILENO, ENTRE OTROS, QUE AUMENTA LA ESTABILIDAD DURANTE EL ALMACENAMIENTO DEL ESTEROIDE Y C) UN ADYUVANTE SOLIDO TAL COMO DIOXIDO DE SILICIO, LACTOSA MICRONIZADA, CELULOSA MICROCRISTALINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION ES UTIL COMO ANTICONCEPTIVOIT REFERS TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES A) A STEROID COMPOUND OF FORMULA (I) WHERE R1 IS H OR ALKYL (C1-C6); R2 IS H O CO-ALKYL (C1-C6); R3, R4, R5 AND R6 ARE H, ALKYL (C1-C6), ALKENYL (C2-C6), ARYL (C5-C10), CN, AMONG OTHERS, SUCH AS ETHINYL ESTRADIOL, DESOGESTREL, AMONG OTHERS; B) A NON-IONIC SURFACTANT SUCH AS FATTY ALCOHOLS, STEROLS, SORBITAN ESTERS OF FATTY ACID, POLYOXYETHYLENE GLYCERIDE, AMONG OTHERS, WHICH INCREASES THE STABILITY DURING STORAGE OF STEROID, STEROID SOLIDIZED, AND C) LIQUID SOLID SORBITANE ADJUSTABLE C) MICROCRYSTALLINE CELLULOSE, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE. SUCH COMPOSITION IS USEFUL AS A CONTRACEPTIVE

PE2005001407A 2004-12-10 2005-12-06 PHARMACEUTICAL COMPOSITION INCLUDING A STEROID PE20061161A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004059880A DE102004059880A1 (en) 2004-12-10 2004-12-10 Stable, hormone-containing (intermediate) product

Publications (1)

Publication Number Publication Date
PE20061161A1 true PE20061161A1 (en) 2006-12-03

Family

ID=36121547

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001407A PE20061161A1 (en) 2004-12-10 2005-12-06 PHARMACEUTICAL COMPOSITION INCLUDING A STEROID

Country Status (4)

Country Link
AR (1) AR052045A1 (en)
DE (1) DE102004059880A1 (en)
PE (1) PE20061161A1 (en)
WO (1) WO2006061340A2 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41417B1 (en) * 1974-06-13 1980-01-02 Squibb & Sons Inc Stabilized steroid formulations
DE3723788A1 (en) * 1987-07-16 1989-01-26 Schering Ag 11 (BETA) -PHENYL-4,9,15-ESTRATRIENE, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
ES2164286T3 (en) * 1993-04-20 2002-02-16 Hexal Ag EMPLASTO WITH ACTIVE SUBSTANCES.
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
US5780050A (en) * 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
US20010023261A1 (en) * 1997-01-27 2001-09-20 Lg Chemical Limited. Novel composition for the transdermal administration of drugs
KR100215027B1 (en) * 1997-01-27 1999-08-16 성재갑 Composition for transdermal administration of steroid drugs and formulation containing same

Also Published As

Publication number Publication date
AR052045A1 (en) 2007-02-28
WO2006061340A2 (en) 2006-06-15
DE102004059880A1 (en) 2006-06-14
WO2006061340A3 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
PE20230234A1 (en) BENZOTI(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS
CA2628607A1 (en) Androgen synthesis inhibitors
TR200102861T2 (en) Oral pharmaceutical compositions comprising long chain triglycerides and lipophilic surfactants.
PE20010126A1 (en) PYRROLOTRIAZINES AS KINASE INHIBITORS
PE20150287A1 (en) PHARMACEUTICAL COMPOSITION CONTAINING A TETRAHYDROPHOLIC ACID
CA2690841A1 (en) Synthetic bile acid composition, method, and preparation
PE20141788A1 (en) BETULIN DERIVATIVES
US7323454B2 (en) Etonogestrel esters
TN2011000346A1 (en) Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
PH12014500367A1 (en) Alkyl lactyllactates and processes of making the same
RU2009102772A (en) 18-METHYL-19-NORANDROST-4-EN-17, 17-SPIROESTER (18-METHYL-19-NOR-20-SPIROX-4-EN-3-OH) AND PHARMACEUTICALS THAT CONTAIN
PE20070205A1 (en) TRANSDERMAL RELEASE DEVICES FOR DRUGS CONTAINING DROSPIRENONE AND METHODS OF RELEASE OF THE SAME
AR034392A1 (en) COMPOUNDS DERIVED FROM 3, 16-DIHIDROXI-ESTRA-1,3,5 (10) -TRIENO, EMPLOYMENT OF THE SAME AND STRUCTURAL PARTS OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PE20061161A1 (en) PHARMACEUTICAL COMPOSITION INCLUDING A STEROID
PE20060957A1 (en) PYRAZOLOPYRIDINE COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS
GB1104462A (en) 7ª‡-methyl-steroids of the oestrane series
WO2006003013B1 (en) NOVEL 2-SUBSTITUTED ESTRA-1,3,5(10)-TRIEN-17-ONES USED IN THE FORM OF INHIBITORS OF 17β-HYDROXYSTEROIDDEHYDROGENASE OF TYPE 1
CN1780610A (en) Pharmaceutical composition in the form of a hydrogel for transdermal administration of active substances
CN1298330C (en) Self-administered contraceptive injection of oily solution
CN1655848A (en) Use of new etonogestrel esters
PE20070644A1 (en) DERIVATIVES OF 9-CHLORO-15-DEOXIPROSTAGLANDINA AS AGONISTS OF THE RECEPTOR PROSTAGLANDIN E2 (EP2) AND PROCESSES FOR THEIR PREPARATION
PE20020752A1 (en) STEROIDS WITH DOUBLE LINK DELTA 14 REPLACED IN POSITIONS 13 AND 14 WITH ANDROGENIC AND PROGESTAGEN ACTIVITY
JPS61221197A (en) Aqueous crystal suspension of steroid glycobenzoate and 17-tertiary steroid glycoester
TW200738712A (en) Emulsified skin external preparation and method for stabilizing the skin external preparation
PE20061181A1 (en) PROCESS FOR THE PURIFICATION OF SUBSTITUTED BENZOXAZOLE COMPOUNDS

Legal Events

Date Code Title Description
FC Refusal