PE20061137A1 - Compuestos derivados de macrolidos amino sustituidas - Google Patents
Compuestos derivados de macrolidos amino sustituidasInfo
- Publication number
- PE20061137A1 PE20061137A1 PE2005001311A PE2005001311A PE20061137A1 PE 20061137 A1 PE20061137 A1 PE 20061137A1 PE 2005001311 A PE2005001311 A PE 2005001311A PE 2005001311 A PE2005001311 A PE 2005001311A PE 20061137 A1 PE20061137 A1 PE 20061137A1
- Authority
- PE
- Peru
- Prior art keywords
- morocco
- quinolinyl
- dihydro
- oxo
- carboxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- -1 AMINO Chemical class 0.000 title abstract 3
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 229940041033 macrolides Drugs 0.000 title 1
- 241000191940 Staphylococcus Species 0.000 abstract 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE A ES C(O), N(R7)-CH2, C(=NR10), ENTRE OTROS, DONDE R7 ES H O ALQUILO(C1-C6), R10 ES OR21 DONDE R21 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS; R1 ES UN COMPUESTO DE FORMULA (IB) O (IC) DONDE R13 ES OC(O)(CH2)dU1R14, O(CH2)dU1R14, ENTRE OTROS, DONDE d ES DE 2 A 5, R14 ES UN HETEROCICLICO, U1 ES Y(CH2)rZ O Y(CH2)r DONDE Y Y Z ES O, ENTRE OTROS, r ES DE 2 A 5; R2 ES H O UN GRUPO PROTECTOR DE HIDROXILO; R3 ES H, ALQUILO(C1-C4) O ALQUENILO(C3-C6) OPCIONALMENTE SUSTITUIDO CON HETEROARILO BICICLICO CONDENSADO DE 9 A 10 MIEMBROS; R4 ES OH, ALQUENILOXI(C3-C6) OPCIONALMENTE SUSTITUIDO CON HETEROARILO BICICLICO CONDENSADO DE 9 A 10 MIEMBROS O ALCOXI(C1-C6) OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C6), ENTRE OTROS; R5 ES HIDROXI, ENTRE OTROS; R6 ES H O F. SON COMPUESTOS PREFERIDOS: 4"-O-{3-[3-(3-CARBOXI-1,4-DIHIDRO-1-DIMETILAMINO-4-OXO-6-QUINOLINIL)PROPILAMINO]PROPIONIL}-6-O-METILERITROMICINA A, 4"-O-{3-[3-(3-CARBOXI-1,4-DIHIDRO-1-DIMETILAMINO-4-OXO-7-QUINOLINIL)PROPILAMINO]PROPIONIL}-AZITROMICIN-11,12-CARBONATO, 4"-O-{3-[3-(3-CARBOXI-1,4-DIHIDRO-1-(MORFOLIN-4-IL)-4-OXO-6-QUINOLINIL)PROPILAMINO]PROPIONIL}-6-O-METILERITROMICINA A, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTIMICROBIANA CONTRA BACTERIAS GRAM-POSITIVAS TALES COMO STAPHYLOCOCCUS AUREUS, MORAXELLA CATARRHALIS, STREPTOCOCCUS PYOGENES, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0424959A GB0424959D0 (en) | 2004-11-11 | 2004-11-11 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061137A1 true PE20061137A1 (es) | 2006-12-13 |
Family
ID=33523587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001311A PE20061137A1 (es) | 2004-11-11 | 2005-11-09 | Compuestos derivados de macrolidos amino sustituidas |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7718621B2 (es) |
| EP (1) | EP1824870A1 (es) |
| JP (1) | JP2008519788A (es) |
| KR (1) | KR20070085919A (es) |
| CN (1) | CN101098881A (es) |
| AR (1) | AR053311A1 (es) |
| AU (1) | AU2005303961A1 (es) |
| BR (1) | BRPI0517792A (es) |
| CA (1) | CA2587413A1 (es) |
| GB (1) | GB0424959D0 (es) |
| IL (1) | IL182978A0 (es) |
| MA (1) | MA29213B1 (es) |
| MX (1) | MX2007005776A (es) |
| NO (1) | NO20072939L (es) |
| PE (1) | PE20061137A1 (es) |
| RU (1) | RU2007121581A (es) |
| TW (1) | TW200630378A (es) |
| WO (1) | WO2006050942A1 (es) |
| ZA (1) | ZA200703603B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080391A2 (en) | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
| WO2007054295A1 (en) * | 2005-11-09 | 2007-05-18 | Glaxo Group Limited | New 4*-substituted erythromycin derivative |
| EP1879904A1 (en) * | 2005-05-10 | 2008-01-23 | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. | 4" amino linked macrolides useful for the treatment of microbial infections |
| EP1945652A1 (en) * | 2005-11-09 | 2008-07-23 | Glaxo Group Limited | Macrolones |
| ES2445442T3 (es) | 2007-09-14 | 2014-03-03 | Vertex Pharmaceuticals Inc. | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US9453042B2 (en) | 2007-10-25 | 2016-09-27 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
| CN102245195B (zh) | 2008-10-24 | 2016-01-13 | 森普拉制药公司 | 使用含三唑的大环内酯的生物防御 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| CN102724874B (zh) | 2009-09-10 | 2018-06-01 | 森普拉制药公司 | 治疗疟疾、结核病和mac疾病的方法 |
| CA2799937A1 (en) * | 2010-05-20 | 2011-11-24 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| JP6042334B2 (ja) | 2010-09-10 | 2016-12-14 | センプラ ファーマシューティカルズ，インコーポレイテッド | 疾患治療のための水素結合形成フルオロケトライド |
| SG11201405895UA (en) | 2012-03-27 | 2014-10-30 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
| RU2015138796A (ru) | 2013-03-14 | 2017-04-19 | Семпра Фармасьютикалс, Инк. | Способы и составы для лечения респираторных заболеваний |
| HK1218864A1 (zh) | 2013-03-15 | 2017-03-17 | 森普拉制药公司 | 用於制备大环内酯抗菌剂的收敛方法 |
| CN106589023A (zh) * | 2016-11-22 | 2017-04-26 | 宜昌东阳光药业股份有限公司 | 一种罗红霉素杂质及其合成方法 |
| JP7344125B2 (ja) | 2017-03-30 | 2023-09-13 | エフ． ホフマン－ラ ロシュ アーゲー | 細菌感染の治療及び予防のための新規ピリド［２，３－ｂ］インドール化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2808070A1 (de) | 1978-02-24 | 1979-08-30 | Bayer Ag | Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten |
| GB0127349D0 (en) | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| GB0225384D0 (en) | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-11-11 GB GB0424959A patent/GB0424959D0/en not_active Ceased
-
2005
- 2005-11-09 RU RU2007121581/04A patent/RU2007121581A/ru not_active Application Discontinuation
- 2005-11-09 CA CA002587413A patent/CA2587413A1/en not_active Abandoned
- 2005-11-09 JP JP2007540573A patent/JP2008519788A/ja not_active Withdrawn
- 2005-11-09 AU AU2005303961A patent/AU2005303961A1/en not_active Abandoned
- 2005-11-09 PE PE2005001311A patent/PE20061137A1/es not_active Application Discontinuation
- 2005-11-09 CN CNA2005800463765A patent/CN101098881A/zh active Pending
- 2005-11-09 US US11/719,004 patent/US7718621B2/en not_active Expired - Fee Related
- 2005-11-09 MX MX2007005776A patent/MX2007005776A/es unknown
- 2005-11-09 KR KR1020077012942A patent/KR20070085919A/ko not_active Withdrawn
- 2005-11-09 BR BRPI0517792-8A patent/BRPI0517792A/pt not_active IP Right Cessation
- 2005-11-09 TW TW094139277A patent/TW200630378A/zh unknown
- 2005-11-09 AR ARP050104704A patent/AR053311A1/es not_active Application Discontinuation
- 2005-11-09 EP EP05801894A patent/EP1824870A1/en not_active Withdrawn
- 2005-11-09 WO PCT/EP2005/012038 patent/WO2006050942A1/en not_active Ceased
-
2006
- 2006-11-07 US US12/093,145 patent/US20080269146A1/en not_active Abandoned
-
2007
- 2007-05-03 IL IL182978A patent/IL182978A0/en unknown
- 2007-05-04 ZA ZA200703603A patent/ZA200703603B/en unknown
- 2007-05-22 MA MA29930A patent/MA29213B1/fr unknown
- 2007-06-08 NO NO20072939A patent/NO20072939L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL182978A0 (en) | 2007-08-19 |
| RU2007121581A (ru) | 2008-12-20 |
| BRPI0517792A (pt) | 2008-10-21 |
| US7718621B2 (en) | 2010-05-18 |
| US20080269146A1 (en) | 2008-10-30 |
| ZA200703603B (en) | 2008-07-30 |
| CN101098881A (zh) | 2008-01-02 |
| CA2587413A1 (en) | 2006-05-18 |
| GB0424959D0 (en) | 2004-12-15 |
| TW200630378A (en) | 2006-09-01 |
| NO20072939L (no) | 2007-08-08 |
| JP2008519788A (ja) | 2008-06-12 |
| AR053311A1 (es) | 2007-05-02 |
| US20080090773A1 (en) | 2008-04-17 |
| AU2005303961A1 (en) | 2006-05-18 |
| WO2006050942A1 (en) | 2006-05-18 |
| KR20070085919A (ko) | 2007-08-27 |
| EP1824870A1 (en) | 2007-08-29 |
| MA29213B1 (fr) | 2008-02-01 |
| MX2007005776A (es) | 2007-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |