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PE20060197A1 - Heterociclos biciclicos como inhibidores de cinasa - Google Patents

Heterociclos biciclicos como inhibidores de cinasa

Info

Publication number
PE20060197A1
PE20060197A1 PE2005000454A PE2005000454A PE20060197A1 PE 20060197 A1 PE20060197 A1 PE 20060197A1 PE 2005000454 A PE2005000454 A PE 2005000454A PE 2005000454 A PE2005000454 A PE 2005000454A PE 20060197 A1 PE20060197 A1 PE 20060197A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
halogen
heterocycles
bicycle
Prior art date
Application number
PE2005000454A
Other languages
English (en)
Inventor
Robert M Borzilleri
Kyoung Kim
Zhen-Wei Cai
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20060197A1 publication Critical patent/PE20060197A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I O II, DONDE R1 ES H, ALQUILO, ALQUILO SUSTITUIDO, ALQUENILO, CICLOALQUILO, ENTRE OTROS; R2 ES H, HALOGENO, CIANO, NO2, CICLOALQUILO, ENTRE OTROS; V ES CH2, NR8; W Y X SON CADA UNO C, N; Y ES O, S, NR9; Z ES -CR10R11, (CR10R11)mNR12-; m ES 0-2; A ES A, B, ENTRE OTROS; G ES C-HALOGENO, ALQUILO, CICLOALQUILO, ENTRE OTROS; Q ES O, NH, N-ALQUILO, ENTRE OTROS; R3, R4, R8 Y R12 SON CADA UNO H, ALQUILO, ALQUENILO, ALQUINILO SUSTITUIDO, ENTRE OTROS; R9 ES H, ALQUILO, CN, NO2, SO2AMINO; R10 Y R11 SON CADA UNO H, HALOGENO, ALQUILO, HETEROARILO, ENTRE OTROS; R13, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 Y R25 SON CADA UNO H, HALOGENO, ALQUILO, CICLOALQUILO, HETEROCICLOALQUILO, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(4-(4-AMINO-1H-PIRROLO[3,2-c]PIRIDIN-1-IL)FENIL-3-(2-(4-FLUOROFENIL)ACETIL)UREA, SALDE CLOHIDRATO; N1-(4-(4-AMINO-1H-PIRROLO[3,2-c]PIRIDIN-1-IL)FENIL-N3-(4-FLUOROFENIL)MALONAMIDA, SALDE CLOHIDRATO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA TIROSINA CINASA UTILES EN EL TRATAMIENTO DE CANCER
PE2005000454A 2004-04-26 2005-04-25 Heterociclos biciclicos como inhibidores de cinasa PE20060197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56538104P 2004-04-26 2004-04-26

Publications (1)

Publication Number Publication Date
PE20060197A1 true PE20060197A1 (es) 2006-03-15

Family

ID=35159810

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000454A PE20060197A1 (es) 2004-04-26 2005-04-25 Heterociclos biciclicos como inhibidores de cinasa

Country Status (6)

Country Link
US (1) US7566784B2 (es)
EP (1) EP1742948A2 (es)
AR (1) AR049263A1 (es)
PE (1) PE20060197A1 (es)
TW (1) TW200538453A (es)
WO (1) WO2005116028A2 (es)

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CN102161663B (zh) * 2008-03-05 2014-03-19 梅特希尔基因公司 蛋白酪氨酸激酶活性的抑制剂
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CA2740885C (en) * 2008-10-16 2018-04-03 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
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KR20130118612A (ko) * 2012-04-20 2013-10-30 (주)네오믹스 신규한 아미노피리딘 유도체 및 이의 용도
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CN111423366B (zh) * 2020-04-28 2022-05-27 山东汇海医药化工有限公司 一种吡非尼酮的制备方法
CN114262322B (zh) * 2020-09-16 2026-01-06 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
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KR100799534B1 (ko) 2004-02-27 2008-01-31 에자이 알앤드디 매니지먼트 가부시키가이샤 신규 피리딘 유도체 및 피리미딘 유도체(1)
DE102004017438A1 (de) 2004-04-08 2005-11-03 Bayer Healthcare Ag Hetaryloxy-substituierte Phenylaminopyrimidine
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
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US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors

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AR049263A1 (es) 2006-07-12
US20050239820A1 (en) 2005-10-27
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TW200538453A (en) 2005-12-01
US7566784B2 (en) 2009-07-28
WO2005116028A2 (en) 2005-12-08

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