PE20060014A1 - Taxanos con sustituyentes lactiloxilo en el c7 - Google Patents
Taxanos con sustituyentes lactiloxilo en el c7Info
- Publication number
- PE20060014A1 PE20060014A1 PE2005000247A PE2005000247A PE20060014A1 PE 20060014 A1 PE20060014 A1 PE 20060014A1 PE 2005000247 A PE2005000247 A PE 2005000247A PE 2005000247 A PE2005000247 A PE 2005000247A PE 20060014 A1 PE20060014 A1 PE 20060014A1
- Authority
- PE
- Peru
- Prior art keywords
- benzoxicarbonyl
- taxane
- lactyloxyl
- furanil
- diasteroisomers
- Prior art date
Links
- -1 LACTYLOXYL SUBSTITUENTS Chemical group 0.000 title abstract 3
- 229940123237 Taxane Drugs 0.000 abstract 3
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 3
- 229960003668 docetaxel Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000422193 Ormyrus Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA PREPARACION FARMACEUTICA QUE COMPRENDE UN TAXANO CARACTERIZADO POR TENER UN SUSTITUYENTE LACTILOXILO EN EL C(7), DE FORMULA (I), EN DONDE X3 ES FURANILO, X5 ES T-BUTOXICARBONILO, Bz ES BENZOILO Y Ac ES ACETILO. ESTE TAXANO COMPRENDE UN CARBONO QUIRAL POR LO QUE PUEDEN ESTAR PRESENTES COMO DIASTEROISOMERO R O S, O UNA MEZCLA DE AMBOS DIASTEROISOMEROS: 7-((S)-(-)-2-HIDROXILOXIPROPIONIL)-2-FURANIL-DOCETAXEL Y 7-((R)-(+)-2-HIDROXILOXIPROPIONIL)-2-FURANIL-DOCETAXEL Y PUEDEN ESTAR PRESENTES EN UNA MEZCLA RACEMICA U OPTICAMENTE ACTIVA, CON UNA RELACION MOLAR DE LOS DIASTEROISOMEROS DE AL MENOS 5:1, 10:1, 20:1 DE UNO CON RELACION AL OTRO. ESTOS COMPUESTOS SE ENCUENTRAN EN FORMA CRISTALINA Y ES OBTENIDO MEDIANTE UN METODO QUE COMPRENDE LA CRISTALIZACION DEL TAXANO A PARTIR DE UNA SOLUCION. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA DE FORMA LIQUIDA O SOLIDA QUE LOS COMPRENDE, DE ADMINISTRACION POR VIA ORAL O PARENTERAL Y SON UTILES COMO AGENTES ANTITUMORALES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55071204P | 2004-03-05 | 2004-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060014A1 true PE20060014A1 (es) | 2006-02-18 |
Family
ID=34975310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000247A PE20060014A1 (es) | 2004-03-05 | 2005-03-04 | Taxanos con sustituyentes lactiloxilo en el c7 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7160919B2 (es) |
| EP (1) | EP1737444A4 (es) |
| JP (1) | JP2007527432A (es) |
| CN (1) | CN1960721A (es) |
| AR (1) | AR048078A1 (es) |
| GT (1) | GT200500041A (es) |
| PA (1) | PA8625301A1 (es) |
| PE (1) | PE20060014A1 (es) |
| SV (1) | SV2006002036A (es) |
| TW (1) | TW200540164A (es) |
| WO (1) | WO2005087222A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104650109B (zh) * | 2013-11-22 | 2019-01-01 | 江苏天士力帝益药业有限公司 | 紫杉烷类化合物 |
| KR102420468B1 (ko) | 2016-03-14 | 2022-07-13 | 위스콘신 얼럼나이 리서어치 화운데이션 | 올리고락트산 컨쥬게이트 및 향상된 항암 효능을 갖는 마이셀 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5489601A (en) | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| DK0552041T3 (da) | 1992-01-15 | 2000-10-09 | Squibb & Sons Inc | Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| CA2130578A1 (en) | 1992-04-17 | 1993-10-28 | Geewananda P. Gunawardana | Taxol derivatives |
| US5248796A (en) | 1992-06-18 | 1993-09-28 | Bristol-Myers Squibb Company | Taxol derivatives |
| US5319112A (en) | 1992-08-18 | 1994-06-07 | Virgnia Tech Intellectual Properties, Inc. | Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol |
| WO1994005282A1 (en) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
| CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| WO1994014787A1 (en) | 1992-12-23 | 1994-07-07 | Bristol-Myers Squibb Company | Novel sidechain-bearing taxanes and intermediates thereof |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| ES2193155T3 (es) * | 1993-03-22 | 2003-11-01 | Univ Florida State | Taxanos que tienen la cadena lateral sustituida por furilo o tienilo. |
| CA2161328A1 (en) | 1993-06-11 | 1994-12-22 | Robert C. Kelly | Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| FR2711369B1 (fr) | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
| US5415869A (en) | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| TW354293B (en) | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5767297A (en) | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| FR2745814B1 (fr) | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| WO1997042181A1 (en) | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| WO1997044026A1 (en) | 1996-05-22 | 1997-11-27 | Neuromedica, Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| US6136988A (en) | 1998-04-10 | 2000-10-24 | Hauser, Inc. | 7-hexanoyltaxol and methods for preparing the same |
| US6146659A (en) | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| JP2003502401A (ja) | 1999-06-21 | 2003-01-21 | ナプロ バイオセラピューティクス，インコーポレイテッド | Ｃ−２ヒドロキシル保護−ｎ−アシル（２ｒ，３ｓ）−３−フェニルイソセリン活性化エステルおよびそれらの製造方法 |
| WO2001025223A1 (en) | 1999-10-06 | 2001-04-12 | The Research Foundation Of State University Of New York | Stabilization of taxane-containing dispersed systems |
| WO2001057013A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | Taxane formulations having improved solubility |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| US6673833B2 (en) * | 2000-02-02 | 2004-01-06 | Fsu Research Foundation, Inc. | C7 heterosubstituted acetate taxanes |
| IT1319168B1 (it) | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
-
2005
- 2005-03-04 PE PE2005000247A patent/PE20060014A1/es not_active Application Discontinuation
- 2005-03-04 AR ARP050100847A patent/AR048078A1/es unknown
- 2005-03-04 EP EP05724610A patent/EP1737444A4/en not_active Withdrawn
- 2005-03-04 CN CNA2005800142232A patent/CN1960721A/zh active Pending
- 2005-03-04 GT GT200500041A patent/GT200500041A/es unknown
- 2005-03-04 US US11/071,912 patent/US7160919B2/en not_active Expired - Fee Related
- 2005-03-04 WO PCT/US2005/007100 patent/WO2005087222A1/en not_active Ceased
- 2005-03-04 TW TW094106641A patent/TW200540164A/zh unknown
- 2005-03-04 SV SV2005002036A patent/SV2006002036A/es unknown
- 2005-03-04 PA PA20058625301A patent/PA8625301A1/es unknown
- 2005-03-04 JP JP2007502013A patent/JP2007527432A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1737444A4 (en) | 2008-05-21 |
| SV2006002036A (es) | 2006-03-16 |
| JP2007527432A (ja) | 2007-09-27 |
| US7160919B2 (en) | 2007-01-09 |
| PA8625301A1 (es) | 2006-06-02 |
| US20050209311A1 (en) | 2005-09-22 |
| AR048078A1 (es) | 2006-03-29 |
| GT200500041A (es) | 2005-10-24 |
| WO2005087222A1 (en) | 2005-09-22 |
| TW200540164A (en) | 2005-12-16 |
| CN1960721A (zh) | 2007-05-09 |
| EP1737444A1 (en) | 2007-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |