PE20060871A1 - Compuestos de piridazinona - Google Patents
Compuestos de piridazinonaInfo
- Publication number
- PE20060871A1 PE20060871A1 PE2006000033A PE2006000033A PE20060871A1 PE 20060871 A1 PE20060871 A1 PE 20060871A1 PE 2006000033 A PE2006000033 A PE 2006000033A PE 2006000033 A PE2006000033 A PE 2006000033A PE 20060871 A1 PE20060871 A1 PE 20060871A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydro
- methyl
- thadiazin
- 1lambda6
- pyridazin
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- -1 3-METHYL-BUTYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, ALQUILO, CICLOALQUILO, ARILO, HETEROCICLILO SUSTITUIDOS O NO, ENTRE OTROS; A ES ARILO O HETEROCICLILO DE 5-6 MIEMBROS. SON COMPUESTOS PREFERIDOS: 2-{3-[5-HIDROXI-2-(3-METIL-BUTIL)-3-OXO-6-TIOFEN-2-IL-2,3-DIHIDRO-PIRIDAZIN-4-IL]-1,1-DIOXO-1,2-DIHIDRO-1LAMBDA6-BENZO[1,2,4]TIADIAZIN-7-ILOXI}-ACETAMIDA; 5-HIDROXI-4-(7-METOXI-1,1-DIOXO-1,2-DIHIDRO-1LAMBDA6-BENZO[1,2,4]TIADIAZIN-3-IL)-2-(3-METIL-BUTIL)-6-(1-METIL-1H-PIRROL-2-IL)-2H-PIRIDAZIN-3-ONA; 2-{3-[5-HIDROXI-2-(3-METIL-BUTIL)-3-OXO-6-TIOFEN-2-IL-2,3-DIHIDRO-PIRIDAZIN-4-IL]-1,1-DIOXO-1,2-DIHIDRO-1LAMBDA6-BENZO[1,2,4]TIADIAZIN-7-ILOXI}-N-METIL-ACETAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE ADEMAS UN MODULADOR TIPO RECEPTOR TOLL Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA POLIMERASA DE HCV NS5B UTILES EN EL TRATAMIENTO DE INFECCIONES POR EL VIRUS DE LA HEPATITIS C
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63661604P | 2004-12-17 | 2004-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060871A1 true PE20060871A1 (es) | 2006-09-04 |
Family
ID=36588590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000033A PE20060871A1 (es) | 2004-12-17 | 2006-01-03 | Compuestos de piridazinona |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7425552B2 (es) |
| EP (1) | EP1824847A2 (es) |
| JP (1) | JP2008526687A (es) |
| KR (1) | KR20070100743A (es) |
| CN (1) | CN101137651A (es) |
| AP (1) | AP2007004040A0 (es) |
| AR (1) | AR054214A1 (es) |
| AU (1) | AU2005316396A1 (es) |
| CA (1) | CA2589527A1 (es) |
| CR (1) | CR9204A (es) |
| EA (1) | EA200701297A1 (es) |
| GT (1) | GT200500373A (es) |
| IL (1) | IL183510A0 (es) |
| MX (1) | MX2007007264A (es) |
| NO (1) | NO20073105L (es) |
| PA (1) | PA8657001A1 (es) |
| PE (1) | PE20060871A1 (es) |
| SV (1) | SV2006002347A (es) |
| TW (1) | TW200635596A (es) |
| UY (1) | UY29266A1 (es) |
| WO (1) | WO2006066079A2 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200500373A (es) | 2004-12-17 | 2006-10-02 | Compuestos de piridazinones | |
| PT1928454E (pt) | 2005-05-10 | 2014-12-04 | Intermune Inc | Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress |
| CN102584649A (zh) | 2006-06-22 | 2012-07-18 | 安那迪斯药品股份有限公司 | 吡咯并[1,2-b]哒嗪酮化合物 |
| WO2008051637A2 (en) * | 2006-06-22 | 2008-05-02 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
| TW200840572A (en) | 2006-12-12 | 2008-10-16 | Anadys Pharmaceuticals Inc | 5,6-dihydro-1H-pyridin-2-one compounds |
| US20080214529A1 (en) * | 2006-12-12 | 2008-09-04 | Frank Ruebsam | SATURATED FUSED [1,2-b]PYRIDAZINONE COMPOUNDS |
| US20080188466A1 (en) * | 2006-12-21 | 2008-08-07 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
| US20080275032A1 (en) * | 2006-12-29 | 2008-11-06 | Yuefen Zhou | Pyridazinone compounds |
| US20080227774A1 (en) * | 2007-03-15 | 2008-09-18 | Frank Ruebsam | 5,5-disubstituted-indolizinone compounds |
| UA100120C2 (en) * | 2007-04-03 | 2012-11-26 | Анадис Фармасьютикалз, Инк. | 5,6-dihydro-1h-pyridin-2-one compounds |
| NZ580917A (en) | 2007-05-04 | 2012-06-29 | Vertex Pharma | Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection |
| WO2008144500A2 (en) * | 2007-05-17 | 2008-11-27 | Anadys Pharmaceuticals, Inc. | 1-methyl-benzo[1,2,4]thiadiazine, 1-oxide derivatives |
| ITMI20071012A1 (it) * | 2007-05-18 | 2008-11-19 | St Microelectronics Srl | Dispositivo di memoria migliorato a veloce programmazione |
| US7834009B2 (en) * | 2007-08-27 | 2010-11-16 | Anadys Pharmaceuticals, Inc. | 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| CN102316871B (zh) * | 2008-06-10 | 2014-06-04 | 安那迪斯药品股份有限公司 | [1，2，4]噻二嗪1，1-二氧化合物 |
| WO2010042834A1 (en) | 2008-10-09 | 2010-04-15 | Anadys Pharmaceuticals, Inc. | A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds |
| TW201026675A (en) * | 2008-10-09 | 2010-07-16 | Anadys Pharmaceuticals Inc | 5,6-dihydro-1H-pyridin-2-one compounds |
| WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| WO2011045271A1 (de) | 2009-10-15 | 2011-04-21 | Bayer Cropscience Ag | Herbizid wirksame heterocyclylsubstituierte pyridazinone |
| BR112012009796A2 (pt) | 2009-10-28 | 2020-08-18 | Anadys Pharmaceuticals, Inc. | composto, métodos para tratar ou prevenir infecções por vírus da hepatite c em mamífero necessitado destes usos de composto e de composição farmacêutica. |
| BR112012014729A2 (pt) | 2009-12-18 | 2016-03-29 | Boehringer Ingelheim Int | terapia combinada contra hcv |
| WO2012158271A1 (en) | 2011-04-06 | 2012-11-22 | Anadys Pharmaceuticals, Inc. | Bridged polycyclic compounds as antiviral agents |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014121416A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| ES2886441T3 (es) * | 2014-04-29 | 2021-12-20 | Fmc Corp | Herbicidas de piridazinona |
| JP6428951B2 (ja) * | 2015-12-07 | 2018-11-28 | Dic株式会社 | 重合性化合物の製造方法 |
| CN105999097A (zh) * | 2016-07-08 | 2016-10-12 | 王恩禄 | 一种治疗乙肝的中药组合物 |
| WO2020247366A1 (en) * | 2019-06-05 | 2020-12-10 | University Of Georgia Research Foundation | Compositions and methods for preventing or treating human immunodeficiency virus associated pulmonary arterial hypertension |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ504021A (en) * | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
| EP1292310A1 (en) | 2000-05-10 | 2003-03-19 | SmithKline Beecham Corporation | Novel anti-infectives |
| US20060003346A1 (en) | 2000-08-11 | 2006-01-05 | Ashok Amin | Method for treating hepatitis |
| AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
| AU2002365198A1 (en) | 2001-10-30 | 2003-07-30 | Smithkline Beecham Corporation | Novel anti-infectives |
| US7601709B2 (en) | 2003-02-07 | 2009-10-13 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| SG137868A1 (en) | 2004-08-23 | 2007-12-28 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| GT200500373A (es) | 2004-12-17 | 2006-10-02 | Compuestos de piridazinones | |
| AU2006240730A1 (en) | 2005-04-21 | 2006-11-02 | Nippon Shinyaku Co., Ltd. | Phthalazinone derivative and pharmaceutical comprising the same |
| BRPI0611388A2 (pt) | 2005-05-04 | 2010-09-08 | Hoffmann La Roche | compostos antivirais heterocìclicos, uso dos mesmos e composição farmacêutica |
| CN102584649A (zh) | 2006-06-22 | 2012-07-18 | 安那迪斯药品股份有限公司 | 吡咯并[1,2-b]哒嗪酮化合物 |
-
2005
- 2005-12-16 GT GT200500373A patent/GT200500373A/es unknown
- 2005-12-16 JP JP2007546930A patent/JP2008526687A/ja active Pending
- 2005-12-16 AP AP2007004040A patent/AP2007004040A0/xx unknown
- 2005-12-16 EA EA200701297A patent/EA200701297A1/ru unknown
- 2005-12-16 KR KR1020077016317A patent/KR20070100743A/ko not_active Withdrawn
- 2005-12-16 MX MX2007007264A patent/MX2007007264A/es not_active Application Discontinuation
- 2005-12-16 EP EP05854333A patent/EP1824847A2/en not_active Withdrawn
- 2005-12-16 AR AR20050105305A patent/AR054214A1/es not_active Application Discontinuation
- 2005-12-16 CN CNA2005800430935A patent/CN101137651A/zh active Pending
- 2005-12-16 AU AU2005316396A patent/AU2005316396A1/en not_active Abandoned
- 2005-12-16 TW TW094144751A patent/TW200635596A/zh unknown
- 2005-12-16 US US11/304,902 patent/US7425552B2/en not_active Expired - Fee Related
- 2005-12-16 CA CA002589527A patent/CA2589527A1/en not_active Abandoned
- 2005-12-16 WO PCT/US2005/045588 patent/WO2006066079A2/en not_active Ceased
- 2005-12-19 SV SV2005002347A patent/SV2006002347A/es unknown
- 2005-12-19 PA PA20058657001A patent/PA8657001A1/es unknown
- 2005-12-20 UY UY29266A patent/UY29266A1/es not_active Application Discontinuation
-
2006
- 2006-01-03 PE PE2006000033A patent/PE20060871A1/es not_active Application Discontinuation
-
2007
- 2007-05-29 IL IL183510A patent/IL183510A0/en unknown
- 2007-06-18 NO NO20073105A patent/NO20073105L/no not_active Application Discontinuation
- 2007-06-22 CR CR9204A patent/CR9204A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20060189602A1 (en) | 2006-08-24 |
| PA8657001A1 (es) | 2006-08-03 |
| AP2007004040A0 (en) | 2007-06-30 |
| EP1824847A2 (en) | 2007-08-29 |
| TW200635596A (en) | 2006-10-16 |
| UY29266A1 (es) | 2006-07-31 |
| JP2008526687A (ja) | 2008-07-24 |
| MX2007007264A (es) | 2007-08-14 |
| NO20073105L (no) | 2007-09-13 |
| KR20070100743A (ko) | 2007-10-11 |
| WO2006066079A3 (en) | 2006-12-14 |
| AU2005316396A1 (en) | 2006-06-22 |
| SV2006002347A (es) | 2006-08-25 |
| GT200500373A (es) | 2006-10-02 |
| AR054214A1 (es) | 2007-06-13 |
| EA200701297A1 (ru) | 2007-12-28 |
| US7425552B2 (en) | 2008-09-16 |
| CR9204A (es) | 2007-09-06 |
| WO2006066079A2 (en) | 2006-06-22 |
| CN101137651A (zh) | 2008-03-05 |
| CA2589527A1 (en) | 2006-06-22 |
| IL183510A0 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |