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PE20060723A1 - Derivados de morfina como agentes analgesicos - Google Patents

Derivados de morfina como agentes analgesicos

Info

Publication number
PE20060723A1
PE20060723A1 PE2005001291A PE2005001291A PE20060723A1 PE 20060723 A1 PE20060723 A1 PE 20060723A1 PE 2005001291 A PE2005001291 A PE 2005001291A PE 2005001291 A PE2005001291 A PE 2005001291A PE 20060723 A1 PE20060723 A1 PE 20060723A1
Authority
PE
Peru
Prior art keywords
alcoxy
morphinan
ona
cyclopropylmethyl
dihydroxy
Prior art date
Application number
PE2005001291A
Other languages
English (en)
Inventor
Naoki Izumimoto
Kuniaki Kawamura
Toshikazu Komagata
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of PE20060723A1 publication Critical patent/PE20060723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C5), CICLOALQUILALQUILO(C4-C7), ENTRE OTROS; R2 Y R3 SON H, HIDROXI, ALCOXI(C1-C5), ENTRE OTROS; X ES ALQUILENO(C2-C7), ALQUENILENO(C2-C7), ALQUINILENO(C2-C7); Y ES C(=O), C(=S), S(O), ENTRE OTROS; k ES DE 0 A 8; R5 ES FLUOR, CLORO, BROMO, ENTRE OTROS; R10 ES H, ALQUILO(C1-C5), ALQUENILO(C2-C5), ENTRE OTROS; R11 ES H; R12 ES H, HIDROXI, ALCOXI(C1-C5), ENTRE OTROS; R13 ES H; R14 ES H, HIDROXI, ALCOXI(C1-C5). SON COMPUESTOS PREFERIDOS: [1-(17-CICLOPROPILMETIL-4,5a-EPOXI-3,14-DIHIDROXI-MORFINAN-6a-IL)PIRROLIDIN-2-ONA, [1-(17-CICLOPROPILMETIL-4,5a-EPOXI-3,14-DIHIDROXI-MORFINAN-6b-IL)-3-BENCIL-PIRROLIDIN-2-ONA, [2-(17-CICLOPROPILMETIL-4,5 a-EPOXI-3,14-DIHIDROXI-MORFINAN-6b-IL)-2,3-DIHIDRO-ISOINDOL-1-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON DERIVADOS DE MORFINA UTILES EN EL TRATAMIENTO DEL DOLOR AGUDO Y CRONICO
PE2005001291A 2004-11-04 2005-11-03 Derivados de morfina como agentes analgesicos PE20060723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004320583 2004-11-04

Publications (1)

Publication Number Publication Date
PE20060723A1 true PE20060723A1 (es) 2006-08-29

Family

ID=36319248

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001291A PE20060723A1 (es) 2004-11-04 2005-11-03 Derivados de morfina como agentes analgesicos

Country Status (12)

Country Link
US (1) US8470845B2 (es)
EP (1) EP1820505A4 (es)
JP (1) JP4706636B2 (es)
KR (1) KR101285645B1 (es)
CN (1) CN101090722B (es)
AR (1) AR053098A1 (es)
CA (1) CA2586181C (es)
MX (1) MX2007005336A (es)
NO (1) NO20072832L (es)
PE (1) PE20060723A1 (es)
TW (1) TW200621785A (es)
WO (1) WO2006049248A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806294A (en) * 2005-11-09 2008-02-01 Toray Industries Therapeutic or prophylactic agent for functional intestinal injury
KR20080081057A (ko) * 2005-12-21 2008-09-05 도레이 가부시끼가이샤 진해제
FR2902341B1 (fr) 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
CA2687956C (en) * 2007-05-21 2015-03-31 Toray Industries, Inc. Method for producing pharmaceutical tablet
ES2648037T3 (es) * 2007-05-21 2017-12-28 Toray Industries, Inc. Preparación oral que comprende un ácido orgánico específico y método para mejorar la propiedad de disolución y la estabilidad química de la preparación oral
CN101965187B (zh) * 2007-05-21 2012-11-21 东丽株式会社 结晶性微粉化粒子
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
US20210015813A1 (en) 2018-03-08 2021-01-21 Victoria Link Ltd. Treatment of demyelinating diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (es) * 1964-02-03 1966-10-31
US3318884A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives
NL8102558A (nl) * 1981-05-25 1982-12-16 Alcoa Nederland Bv Lichtmast met versterking van de opening in het onderste gedeelte.
DK0577847T3 (da) * 1992-01-23 1999-06-23 Toray Industries Morphinanderivat og medicinsk anvendelse deraf
CA2143864C (en) 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
WO1996027375A2 (en) 1995-03-03 1996-09-12 Algos Pharmaceutical Corporation Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence
AU6020300A (en) * 1999-07-19 2001-02-05 Toray Industries, Inc. Remedies or preventives for frequent urination or urinary incontinence
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
EP1353909B1 (en) * 2000-10-31 2005-04-06 Rensselaer Polytechnic Institute 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioidreceptor binding agents
US7320984B2 (en) 2002-10-09 2008-01-22 Toray Industries, Inc. Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置
CA2561509C (en) 2004-03-30 2012-08-28 Toray Industries, Inc. Anti-itching agent

Also Published As

Publication number Publication date
CN101090722A (zh) 2007-12-19
JP4706636B2 (ja) 2011-06-22
KR20070085436A (ko) 2007-08-27
NO20072832L (no) 2007-08-01
KR101285645B1 (ko) 2013-07-12
CN101090722B (zh) 2011-12-21
EP1820505A1 (en) 2007-08-22
TW200621785A (en) 2006-07-01
CA2586181C (en) 2012-11-27
AR053098A1 (es) 2007-04-25
CA2586181A1 (en) 2006-05-11
WO2006049248A1 (ja) 2006-05-11
EP1820505A4 (en) 2010-01-20
US20070299100A1 (en) 2007-12-27
HK1115808A1 (en) 2008-12-12
TWI356826B (es) 2012-01-21
JPWO2006049248A1 (ja) 2008-08-07
US8470845B2 (en) 2013-06-25
MX2007005336A (es) 2007-06-25

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