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PE20060712A1 - Compuestos derivados de quinolinamina como moduladores del receptor de quimioquina - Google Patents

Compuestos derivados de quinolinamina como moduladores del receptor de quimioquina

Info

Publication number
PE20060712A1
PE20060712A1 PE2005001007A PE2005001007A PE20060712A1 PE 20060712 A1 PE20060712 A1 PE 20060712A1 PE 2005001007 A PE2005001007 A PE 2005001007A PE 2005001007 A PE2005001007 A PE 2005001007A PE 20060712 A1 PE20060712 A1 PE 20060712A1
Authority
PE
Peru
Prior art keywords
quinolinamine
alkyl
methyl
haloalkyl
alkenyl
Prior art date
Application number
PE2005001007A
Other languages
English (en)
Inventor
Kristjan Gudmundsson
Sharon Davis Boggs
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20060712A1 publication Critical patent/PE20060712A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE QUINOLINAMINA DE FORMULA I, DONDE t ES 0, 1 O 2; R ES H, ALQUILO, ALQUINILO, ENTRE OTROS; R1 ES HALOGENO, HALOALQUILO, ALQUENILO, ENTRE OTROS; n ES 0, 1 0 2; R2 ES H, ALQUILO, HALOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R4 ES HALOGENO, HALOALQUILO, ALQUENILO, ENTRE OTROS; m ES 0, 1 O 2; R5 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; p ES 0 O 1; Y ES NR10, O, C(O), C(O)O, ENTRE OTROS; X ES N(R10)2, RaN(R10)2, ENTRE OTROS; Ra ES ALQUILENO SUSTITUIDO CON OH, O, ALQUILO, ENTRE OTROS; R10 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-METIL-N-{[5-(4-METIL-1-PIPERAZINIL)IMIDAZO[1,2-a]PIRIDIN-2-IL]METIL}-5,6,7,8-TETRAHIDRO-8-QUINOLINAMINA, N-{[5-(4-ETIL-1-PIPERAZINIL)IMIDAZO[1,2-a]PIRIDIN-2-IL]METIL}-N-METIL-5,6,7,8-TETRAHIDRO-8-QUINOLINAMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SE UNEN ESPECIFICAMENTE AL RECEPTOR DE QUIMIOQUINA, AFECTANDO LA UNION DEL LIGANDO NATURAL O LA QUIMIOQUINA A UN RECEPTOR, TAL COMO CXCR4 Y/O CCR5 DE UNA CELULA BLANCO Y SON UTILES POR SUS EFECTOS PROTECTORES SOBRE CELULAS DE BLANCO CONTRA INFECCION POR VIH
PE2005001007A 2004-09-02 2005-09-01 Compuestos derivados de quinolinamina como moduladores del receptor de quimioquina PE20060712A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60674204P 2004-09-02 2004-09-02
US61076504P 2004-09-17 2004-09-17

Publications (1)

Publication Number Publication Date
PE20060712A1 true PE20060712A1 (es) 2006-08-24

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PE2005001008A PE20060656A1 (es) 2004-09-02 2005-09-01 COMPUESTOS DE IMIDAZO[1,2-a]PIRIDINIL COMO MODULADORES DE LA ACTIVIDAD DE QUIMIOQUINAS
PE2005001007A PE20060712A1 (es) 2004-09-02 2005-09-01 Compuestos derivados de quinolinamina como moduladores del receptor de quimioquina

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PE2005001008A PE20060656A1 (es) 2004-09-02 2005-09-01 COMPUESTOS DE IMIDAZO[1,2-a]PIRIDINIL COMO MODULADORES DE LA ACTIVIDAD DE QUIMIOQUINAS

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US (2) US20070254910A1 (es)
EP (2) EP1799671A4 (es)
JP (2) JP2008511669A (es)
KR (2) KR20070053313A (es)
AR (2) AR051565A1 (es)
AU (2) AU2005279835A1 (es)
BR (1) BRPI0514881A (es)
CA (2) CA2578746A1 (es)
IL (1) IL181419A0 (es)
MA (1) MA28872B1 (es)
MX (2) MX2007002679A (es)
NO (2) NO20071366L (es)
PE (2) PE20060656A1 (es)
RU (2) RU2351592C2 (es)
TW (2) TW200612921A (es)
WO (2) WO2006026703A2 (es)

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Publication number Publication date
WO2006026703A8 (en) 2006-05-26
PE20060656A1 (es) 2006-08-24
TW200612921A (en) 2006-05-01
CA2579059A1 (en) 2006-03-16
RU2351592C2 (ru) 2009-04-10
MX2007002615A (es) 2007-04-27
MA28872B1 (fr) 2007-09-03
WO2006028896A3 (en) 2006-04-27
NO20071418L (no) 2007-05-31
CA2578746A1 (en) 2006-03-09
US20070232615A1 (en) 2007-10-04
JP2008511669A (ja) 2008-04-17
WO2006028896A2 (en) 2006-03-16
WO2006026703A3 (en) 2006-10-05
KR20070049682A (ko) 2007-05-11
AU2005279835A1 (en) 2006-03-09
RU2352567C2 (ru) 2009-04-20
TW200621754A (en) 2006-07-01
US20070254910A1 (en) 2007-11-01
AR051565A1 (es) 2007-01-24
AU2005282753A1 (en) 2006-03-16
IL181419A0 (en) 2007-07-04
EP1784185A2 (en) 2007-05-16
AR050302A1 (es) 2006-10-11
NO20071366L (no) 2007-05-31
RU2007106779A (ru) 2008-10-10
EP1799671A2 (en) 2007-06-27
EP1799671A4 (en) 2009-06-10
EP1784185A4 (en) 2009-06-03
JP2008511668A (ja) 2008-04-17
WO2006026703A2 (en) 2006-03-09
KR20070053313A (ko) 2007-05-23
BRPI0514881A (pt) 2008-06-24
MX2007002679A (es) 2007-05-16
RU2007106780A (ru) 2008-10-10

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