PE20060644A1 - Procedimiento para la preparacion de dihidropteridinonas - Google Patents

Procedimiento para la preparacion de dihidropteridinonas

Info

Publication number: PE20060644A1
Authority: PE; Peru
Prior art keywords: alkyl; aryl; optionally substituted; formula; dihydropteridinones
Prior art date: 2004-08-14

Application number

PE2005000933A

Other languages

English (en)

Spanish (es)

Inventor

Gunter Linz

Gerd F Kraemer

Geert Asche

Ludwig Gutschera

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-14

Filing date

2005-08-12

Publication date

2006-07-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35907775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060644(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-08-12 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2006-07-24 Publication of PE20060644A1 publication Critical patent/PE20060644A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

PE2005000933A 2004-08-14 2005-08-12 Procedimiento para la preparacion de dihidropteridinonas PE20060644A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04019365		2004-08-14
EP05001611		2005-01-27

Publications (1)

Publication Number	Publication Date
PE20060644A1 true PE20060644A1 (es)	2006-07-24

Family

ID=35907775

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PE2005000933A PE20060644A1 (es)	2004-08-14	2005-08-12	Procedimiento para la preparacion de dihidropteridinonas
PE2009000396A PE20091582A1 (es)	2004-08-14	2005-08-12	Procedimiento para la preparacion de dihidropteridinonas

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PE2009000396A PE20091582A1 (es)	2004-08-14	2005-08-12	Procedimiento para la preparacion de dihidropteridinonas

Country Status (30)

Country	Link
US (3)	US7759485B2 (me)
EP (1)	EP1778668B1 (me)
JP (2)	JP5094391B2 (me)
KR (1)	KR101214394B1 (me)
CN (1)	CN101023070B (me)
AR (1)	AR054078A1 (me)
AU (1)	AU2005274338B2 (me)
BR (1)	BRPI0514361A8 (me)
CA (1)	CA2576290C (me)
CL (1)	CL2010000204A1 (me)
CY (1)	CY1114564T1 (me)
DK (1)	DK1778668T3 (me)
EA (1)	EA013820B1 (me)
EC (1)	ECSP077248A (me)
ES (1)	ES2429873T3 (me)
HR (1)	HRP20130890T1 (me)
IL (1)	IL181303A (me)
ME (1)	ME01599B (me)
MX (1)	MX2007001852A (me)
MY (2)	MY150538A (me)
NO (1)	NO20070753L (me)
NZ (1)	NZ553650A (me)
PE (2)	PE20060644A1 (me)
PL (1)	PL1778668T3 (me)
PT (1)	PT1778668E (me)
RS (1)	RS52917B (me)
SI (1)	SI1778668T1 (me)
TW (1)	TWI355383B (me)
UY (1)	UY29061A1 (me)
WO (1)	WO2006018220A2 (me)

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US6861422B2 (en) *	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de) *	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) *	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
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US7759485B2 (en)	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US7728134B2 (en) *	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
EP1630163A1 (de) *	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de) *	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
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CA2695406A1 (en) *	2007-08-03	2009-02-12	Boehringer Ingelheim International Gmbh	Crystalline form of a dihydropteridione derivative
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EP2569434B1 (en)	2010-05-14	2019-09-04	Dana-Farber Cancer Institute, Inc.	Compositions and methods for treating leukemia and related disorders
US9301962B2 (en)	2010-05-14	2016-04-05	Baylor College Of Medicine	Male contraceptive compositions and methods of use
AU2011252808B2 (en)	2010-05-14	2015-05-14	Dana-Farber Cancer Institute, Inc.	Compositions and methods for treating neoplasia, inflammatory disease and other disorders
US8546566B2 (en) *	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
ES2533042T3 (es)	2011-02-25	2015-04-07	Takeda Pharmaceutical Company Limited	Oxazinopteridinas y oxazinopteridinonas N-sustituidas
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
UY34893A (es)	2012-07-10	2014-02-28	Takeda Pharmaceutical	Derivados de azaindol
WO2014159392A1 (en)	2013-03-14	2014-10-02	Dana-Farber Cancer Institute, Inc.	Bromodomain binding reagents and uses thereof
US9975896B2 (en)	2013-07-25	2018-05-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of transcription factors and uses thereof
US20150031699A1 (en)	2013-07-26	2015-01-29	Boehringer Ingelheim International Gmbh	Treatment of myelodysplastic syndrome
EP3066101B1 (en)	2013-11-08	2020-07-29	Dana-Farber Cancer Institute, Inc.	Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
UY35945A (es)	2014-01-09	2015-08-31	Takeda Pharmaceutical	Derivados de azaindol
MX2016009975A (es) *	2014-01-31	2016-10-31	Dana Farber Cancer Inst Inc	Derivados de dihidropteridinona y sus usos.
HK1225383A1 (zh)	2014-01-31	2017-09-08	达纳-法伯癌症研究所股份有限公司	二氮杂环庚烷衍生物及其用途
CN106029653A (zh)	2014-01-31	2016-10-12	达纳-法伯癌症研究所股份有限公司	二氨基嘧啶苯砜衍生物及其用途
WO2015117087A1 (en)	2014-01-31	2015-08-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
CN106456653A (zh)	2014-02-28	2017-02-22	腾沙治疗公司	高胰岛素血症相关病症的治疗
CN104003989B (zh) *	2014-05-26	2015-11-11	苏州明锐医药科技有限公司	伏拉塞替及其中间体的制备方法
MX2017001757A (es) *	2014-08-08	2017-05-30	Dana Farber Cancer Inst Inc	Derivados de dihidropteridinona y sus usos.
BR112017002369A2 (pt)	2014-08-08	2017-12-05	Dana Farber Cancer Inst Inc	derivados de diazepana e usos dos mesmos
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
EP3212654B1 (en)	2014-10-27	2020-04-08	Tensha Therapeutics, Inc.	Bromodomain inhibitors
CN105646398B (zh) *	2014-12-05	2018-09-07	上海医药工业研究院	N-((1r,4r)-4-(4-(环丙基甲基)哌嗪-1-基)环己基)乙酰胺的制备方法
EP3307728A4 (en)	2015-06-12	2019-07-17	Dana Farber Cancer Institute, Inc.	COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
PE20181086A1 (es)	2015-09-11	2018-07-05	Dana Farber Cancer Inst Inc	Acetamida tienotrizolodiazepinas y usos de las mismas
RU2750164C2 (ru)	2015-09-11	2021-06-22	Дана-Фарбер Кэнсер Инститьют, Инк.	Цианотиенотриазолодиазепины и пути их применения
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.

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DE102004033670A1 (de)	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
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US7759485B2 (en) *	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en) *	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
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EP1630163A1 (de)	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de)	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
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CA2695406A1 (en) *	2007-08-03	2009-02-12	Boehringer Ingelheim International Gmbh	Crystalline form of a dihydropteridione derivative

2005
- 2005-08-04 US US11/197,289 patent/US7759485B2/en active Active
- 2005-08-11 DK DK05771218.4T patent/DK1778668T3/da active
- 2005-08-11 ME MEP-2013-91A patent/ME01599B/me unknown
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2007
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2010
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Also Published As

Publication number	Publication date
JP5094391B2 (ja)	2012-12-12
HRP20130890T1 (hr)	2013-10-25
CA2576290A1 (en)	2006-02-23
BRPI0514361A8 (pt)	2018-04-17
JP2012232990A (ja)	2012-11-29
KR20070050966A (ko)	2007-05-16
MY150538A (en)	2014-01-30
IL181303A0 (en)	2007-07-04
EP1778668A2 (de)	2007-05-02
CL2010000204A1 (es)	2010-12-03
PT1778668E (pt)	2013-08-01
EA200700199A1 (ru)	2007-08-31
AU2005274338A1 (en)	2006-02-23
US8138341B2 (en)	2012-03-20
AR054078A1 (es)	2007-06-06
JP2008509951A (ja)	2008-04-03
US7759485B2 (en)	2010-07-20
AU2005274338B2 (en)	2012-06-28
EA013820B1 (ru)	2010-08-30
TWI355383B (en)	2012-01-01
MX2007001852A (es)	2007-03-28
US20100249412A1 (en)	2010-09-30
KR101214394B1 (ko)	2012-12-21
ME01599B (me)	2014-09-20
BRPI0514361A (pt)	2008-06-10
MY145652A (en)	2012-03-15
UY29061A1 (es)	2006-03-31
IL181303A (en)	2015-10-29
ES2429873T3 (es)	2013-11-18
NO20070753L (no)	2007-05-07
PL1778668T3 (pl)	2013-11-29
WO2006018220A8 (de)	2006-06-15
CN101023070A (zh)	2007-08-22
PE20091582A1 (es)	2009-11-07
NZ553650A (en)	2010-12-24
ECSP077248A (es)	2007-03-29
DK1778668T3 (da)	2013-09-30
SI1778668T1 (sl)	2013-11-29
WO2006018220A2 (de)	2006-02-23
HK1107821A1 (en)	2008-04-18
CA2576290C (en)	2013-07-16
CY1114564T1 (el)	2016-10-05
WO2006018220A3 (de)	2006-10-12
EP1778668B1 (de)	2013-07-03
RS52917B (sr)	2014-02-28
US20080177066A1 (en)	2008-07-24
TW200621779A (en)	2006-07-01
US8138373B2 (en)	2012-03-20
CN101023070B (zh)	2012-12-05
US20100249458A1 (en)	2010-09-30

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Date	Code	Title	Description
2009-06-22	FG	Grant, registration
2019-03-27	FD	Application declared void or lapsed