[go: up one dir, main page]

PE20060465A1 - Composiciones que contienen policosanol y un inhibidor de reductasa hmg-coa - Google Patents

Composiciones que contienen policosanol y un inhibidor de reductasa hmg-coa

Info

Publication number
PE20060465A1
PE20060465A1 PE2005000582A PE2005000582A PE20060465A1 PE 20060465 A1 PE20060465 A1 PE 20060465A1 PE 2005000582 A PE2005000582 A PE 2005000582A PE 2005000582 A PE2005000582 A PE 2005000582A PE 20060465 A1 PE20060465 A1 PE 20060465A1
Authority
PE
Peru
Prior art keywords
policosanol
coa
hmg
compositions containing
reductase inhibitor
Prior art date
Application number
PE2005000582A
Other languages
English (en)
Inventor
Roger Berlin
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20060465A1 publication Critical patent/PE20060465A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE POLICOSANOL Y UN INHIBIDOR DE LA ENZIMA HMG-COA REDUCTASA DE METILGLUTARIL. DICHO POLICOSANOL COMPRENDE UNA MEZCLA DE ALCOHOLES ALIFATICOS PRIMARIOS DE CADENA RECTA CON UN LARGO DE 20 A 36 ATOMOS DE CARBONO, ENTRE LOS CUALES SE ENCUENTRAN 1-EICOSANOL, 1-DOCOSANOL, 1-TETRACOSANOL, ENTRE OTROS. EL INHIBIDOR DE HMG-COA ES UNA ESTATINA TAL COMO LOVASTATIN, ROSUVASTATIN, PRAVASTATIN, ENTRE OTRAS. EL POLICOSANOL Y LA ESTATINA SE ENCUENTRAN EN UNA PROPORCION DE ENTRE 100:1 A 0,01:1 POR PESO. TAMBIEN ESTA REFERIDA A UNA PREPARACION TRANSDERMICA CON LIBERACION SOSTENIDA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES HIPERCOLESTEROLEMICAS, COLESTEROL TOTAL, COLESTEROL LDL, ENFERMEDAD CARDIACA CORONARIA, INFLAMACION, ENTRE OTRAS
PE2005000582A 2004-05-25 2005-05-25 Composiciones que contienen policosanol y un inhibidor de reductasa hmg-coa PE20060465A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/853,578 US20050267197A1 (en) 2004-05-25 2004-05-25 Compositions containing policosanol and HMG-Co-A reductase inhibitor and their pharmaceutical uses

Publications (1)

Publication Number Publication Date
PE20060465A1 true PE20060465A1 (es) 2006-06-12

Family

ID=35426221

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000582A PE20060465A1 (es) 2004-05-25 2005-05-25 Composiciones que contienen policosanol y un inhibidor de reductasa hmg-coa

Country Status (4)

Country Link
US (1) US20050267197A1 (es)
PE (1) PE20060465A1 (es)
TW (1) TW200605865A (es)
WO (1) WO2005115381A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050272770A1 (en) * 2004-04-29 2005-12-08 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7199126B2 (en) * 2004-04-29 2007-04-03 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050282883A1 (en) * 2004-04-29 2005-12-22 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
MX2007001553A (es) * 2004-08-06 2008-03-07 Transform Pharmaceuticals Inc Nuevas composiciones farmaceuticas de estatina y metodos de tratamiento relacionados.
SG155189A1 (en) * 2004-08-06 2009-09-30 Transform Pharmaceuticals Inc Novel fenofibrate formulations and related methods of treatment
US20060111436A1 (en) * 2004-11-23 2006-05-25 John Griffin Compositions and treatments for modulating kinase and/or HMG-CoA reductase
WO2006087117A1 (en) * 2005-02-17 2006-08-24 Chiesi Farmaceutici S.P.A. Therapeutic combinations of manidi pine and a statin
US20070015779A1 (en) * 2005-04-29 2007-01-18 John Griffin Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
PT2018153E (pt) 2006-04-26 2012-07-04 Rosemont Pharmaceuticals Ltd Composições orais líquidas
US8969514B2 (en) * 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US20100178341A1 (en) * 2008-06-11 2010-07-15 Ranbaxy Laboratories Limited BILAYERED TABLET COMPRISING NIACIN AND HMG-CoA REDUCTASE INHIBITOR
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8557236B2 (en) * 2010-02-09 2013-10-15 Vascure Natural LLC Cardiovascular support supplement and compositions and methods thereof
JP6393037B2 (ja) 2010-09-15 2018-09-19 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃアゴニストの製剤および使用方法
WO2013169797A1 (en) 2012-05-07 2013-11-14 Omthera Pharmaceuticals, Inc. Compositions of statins and omega-3 fatty acids
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CN114903862B (zh) * 2022-06-15 2023-08-22 湖北中古生物制药有限公司 一种多廿烷醇阿托伐他汀钙复方制剂及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031376A (en) * 1956-10-11 1962-04-24 Levin Compositions comprising octacosanol, triacontanol, tetracosanol, or hexacosanol, andmethods employing same
US4623667A (en) * 1985-06-28 1986-11-18 Richardson-Vicks Inc. Topical treatment of skin inflammatory disorders
US4793991A (en) * 1986-01-31 1988-12-27 Slimak Karen M Hypoallergenic cosmetics, lip balms and lip sticks
US5166156A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
CU22229A1 (es) * 1992-09-29 1996-01-31 Dalmer Lab Sa Policosanol, una mezcla de alcoholes alifaticos primarios superiores para hipergregabilidad plaquetaria, los accidentes isquemicos, trombosis e incluso efectividad contra ulceras gastricas quimicamente inducidas y su proceso de obtencion de la caña de azucar. el tratamiento de complicaciones ateroscleroticas tales como la
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6596776B2 (en) * 1999-06-21 2003-07-22 Hauser, Inc. High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof
ES2296711T3 (es) * 2000-08-03 2008-05-01 Harting, Thomas Francis Composiciones farmaceuticas y alimenticias que contienen alcoholes de madera o esteroles de madera utiles para rebajar el colesterol del suero.
US20030054978A1 (en) * 2001-08-31 2003-03-20 Babish John G. Arginine compositions for coordinate modification of multiple cardiovascular risk factors
EP1511467A1 (en) * 2002-06-10 2005-03-09 Elan Pharma International Limited Nanoparticulate polycosanol formulations and novel polycosanol combinations
US6890941B1 (en) * 2003-12-03 2005-05-10 Procaps S.A. Compositions containing HMG Co-A reductase inhibitors and policosanol

Also Published As

Publication number Publication date
WO2005115381A3 (en) 2007-05-24
TW200605865A (en) 2006-02-16
US20050267197A1 (en) 2005-12-01
WO2005115381A2 (en) 2005-12-08

Similar Documents

Publication Publication Date Title
PE20060465A1 (es) Composiciones que contienen policosanol y un inhibidor de reductasa hmg-coa
MX2009003920A (es) Estatina y acidos grasos omega 3 para reducir los niveles de apo b.
AR018777A1 (es) Composicion farmaceutica que contiene una combinacion de una estatina y aspirina y metodo.
ES2721148T3 (es) Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso
ECSP10010433A (es) Composición que comprende anticuerpo que se fija al dominio ii de her2, y sus variantes ácidas
AR040588A1 (es) Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
PE20080523A1 (es) Composiciones farmaceuticas topicas que comprenden un modificador de respuesta inmune
MA29909B1 (fr) Derives de pyridazine
AR062792A1 (es) Derivados azetidinona y metodos de uso de estos
SV2011003903A (es) Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa iv para el tratamiento o prevencion de diabetes
NI200700107A (es) (bifenil) ácidos carboxílicos y sus derivados
ECSP077275A (es) Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos
MA32929B1 (fr) Lactames en tant qu'inhibiteurs de bêta-sécrétase
CR9954A (es) Derivados de pirazina
CR10452A (es) Derivados de terfenilo para el tratamiento de enfermedad de alzheimer
PE20000017A1 (es) Combinaciones de estatina-eter carboxialquilico
AR076263A1 (es) Composiciones y metodos para tratar cancer. uso.
GT199900081A (es) Compuestos de sulfonilbenceno como agentes anti-inflamatorios / analgesicos.
UY30675A1 (es) Metodos para el tratamiento de la depresion
PE20060276A1 (es) Composiciones que contienen policosanol, niaciana y/o derivados de niacina
BRPI0518300A2 (pt) derivados de Ácido 7-(2h-pirazol-3-il)-3,5-diidràxi-heptanàico como inibidores da hmg co-a reductase para o tratamento de lipidemia
BRPI0512964A (pt) composições para cuidados pessoais com hipossensibilidade melhorada
AR065670A1 (es) Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas
AR076262A1 (es) Derivados heterociclicos de diazepin-2-ona, composiciones farmaceuticas y sus usos en el tratamiento del cancer
SV2006002089A (es) Nuevos imidazoles ref. docket 18699 (pc26195a)

Legal Events

Date Code Title Description
FC Refusal