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PE20050339A1 - Anticuerpos humanos modificados anti-igf-1r - Google Patents

Anticuerpos humanos modificados anti-igf-1r

Info

Publication number
PE20050339A1
PE20050339A1 PE2004000773A PE2004000773A PE20050339A1 PE 20050339 A1 PE20050339 A1 PE 20050339A1 PE 2004000773 A PE2004000773 A PE 2004000773A PE 2004000773 A PE2004000773 A PE 2004000773A PE 20050339 A1 PE20050339 A1 PE 20050339A1
Authority
PE
Peru
Prior art keywords
igf
refers
amino acid
human antibodies
monoclonal antibody
Prior art date
Application number
PE2004000773A
Other languages
English (en)
Inventor
Bruce David Cohen
Vahe Bedian
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20050339A1 publication Critical patent/PE20050339A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN ANTICUERPO MONOCLONAL HUMANO O UNA PORCION DE UNION AL ANTIGENO DE ESTE QUE COMPRENDE AL MENOS UN RESTO DE AMINOACIDO MUTADO EN UNA POSICION SELECCIONADA QUE SE HA REEMPLAZADO POR EL CORRESPONDIENTE RESTO DE AMINOACIDO DE LA LINEA GERMINAL, EN QUE DICHO REEMPLAZO ES ESPECIFICAMENTE UNA MUTACION SOMATICA CONTENIDA EN UNA REGION MARCO CONSERVADA DE UNA REGION VARIABLE DE DICHO ANTICUERPO Y QUE SE UNE ESPECIFICAMENTE AL RECEPTOR DEL FACTOR DE CRECIMIENTO INSULINOIDE I HUMANO (IGF-IR). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE PUEDE CONTENER ADEMAS UN ANTINEOPLASICO, UN AGENTE QUIMIOTERAPEUTICO O UN ANTITUMORAL. ESTE ANTICUERPO MONOCLONAL ES UTIL EN EL TRATAMIENTO DEL CANCER
PE2004000773A 2003-08-13 2004-08-09 Anticuerpos humanos modificados anti-igf-1r PE20050339A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49520003P 2003-08-13 2003-08-13

Publications (1)

Publication Number Publication Date
PE20050339A1 true PE20050339A1 (es) 2005-05-17

Family

ID=34193291

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000773A PE20050339A1 (es) 2003-08-13 2004-08-09 Anticuerpos humanos modificados anti-igf-1r

Country Status (37)

Country Link
US (2) US7371378B2 (es)
EP (1) EP1656391B1 (es)
JP (1) JP4638870B2 (es)
KR (1) KR100825156B1 (es)
CN (1) CN1835975B (es)
AP (1) AP2006003510A0 (es)
AR (1) AR045247A1 (es)
AT (1) ATE484525T1 (es)
AU (1) AU2004265152A1 (es)
BR (1) BRPI0413466A (es)
CA (1) CA2535071A1 (es)
CL (1) CL2004002035A1 (es)
CR (1) CR8233A (es)
DE (1) DE602004029581D1 (es)
DK (1) DK1656391T3 (es)
EA (1) EA200600234A1 (es)
EC (1) ECSP066359A (es)
ES (1) ES2351395T3 (es)
GT (1) GT200400158A (es)
IL (1) IL173273A (es)
IS (1) IS8266A (es)
MA (1) MA27988A1 (es)
MX (1) MXPA06001634A (es)
NL (1) NL1026829C2 (es)
NO (1) NO20060542L (es)
OA (1) OA13234A (es)
PA (1) PA8608801A1 (es)
PE (1) PE20050339A1 (es)
PL (1) PL1656391T3 (es)
PT (1) PT1656391E (es)
RS (1) RS20060099A (es)
TN (1) TNSN06050A1 (es)
TW (1) TWI294915B (es)
UA (1) UA85058C2 (es)
UY (1) UY28464A1 (es)
WO (1) WO2005016967A2 (es)
ZA (1) ZA200601231B (es)

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Also Published As

Publication number Publication date
CR8233A (es) 2007-01-18
WO2005016967A2 (en) 2005-02-24
CN1835975B (zh) 2012-11-21
CL2004002035A1 (es) 2005-06-03
IS8266A (is) 2006-01-26
ATE484525T1 (de) 2010-10-15
DE602004029581D1 (de) 2010-11-25
BRPI0413466A (pt) 2006-10-17
IL173273A0 (en) 2006-06-11
UY28464A1 (es) 2005-03-31
CN1835975A (zh) 2006-09-20
US20050069539A1 (en) 2005-03-31
AP2006003510A0 (en) 2006-02-28
PL1656391T3 (pl) 2011-03-31
NL1026829A1 (nl) 2005-02-15
GT200400158A (es) 2005-07-22
RS20060099A (sr) 2008-08-07
DK1656391T3 (da) 2011-01-03
EP1656391A2 (en) 2006-05-17
EP1656391B1 (en) 2010-10-13
TWI294915B (en) 2008-03-21
OA13234A (en) 2006-12-13
WO2005016967A3 (en) 2005-04-14
CA2535071A1 (en) 2005-02-24
ECSP066359A (es) 2006-10-31
US7575746B2 (en) 2009-08-18
EA200600234A1 (ru) 2006-08-25
TW200516145A (en) 2005-05-16
AU2004265152A1 (en) 2005-02-24
PA8608801A1 (es) 2005-03-03
MXPA06001634A (es) 2006-04-28
JP2007527705A (ja) 2007-10-04
JP4638870B2 (ja) 2011-02-23
PT1656391E (pt) 2010-12-06
ES2351395T3 (es) 2011-02-04
US7371378B2 (en) 2008-05-13
KR100825156B1 (ko) 2008-04-24
US20080181891A1 (en) 2008-07-31
UA85058C2 (ru) 2008-12-25
NO20060542L (no) 2006-05-03
AR045247A1 (es) 2005-10-19
KR20060035796A (ko) 2006-04-26
TNSN06050A1 (fr) 2007-10-03
NL1026829C2 (nl) 2005-07-05
IL173273A (en) 2011-10-31
MA27988A1 (fr) 2006-07-03
ZA200601231B (en) 2007-05-30

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