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PE20050442A1 - DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE AS ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS - Google Patents

DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE AS ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS

Info

Publication number
PE20050442A1
PE20050442A1 PE2004001004A PE2004001004A PE20050442A1 PE 20050442 A1 PE20050442 A1 PE 20050442A1 PE 2004001004 A PE2004001004 A PE 2004001004A PE 2004001004 A PE2004001004 A PE 2004001004A PE 20050442 A1 PE20050442 A1 PE 20050442A1
Authority
PE
Peru
Prior art keywords
octane
azoniabiciclo
antagonists
derivatives
acetylcholine receptors
Prior art date
Application number
PE2004001004A
Other languages
Spanish (es)
Inventor
Michael R Palovich
Zehong Wan
Chongjie Zhu
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20050442A1 publication Critical patent/PE20050442A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A DERIVADOS DE 8-AZONIABICICLO[3.2.1]OCTANO DE FORMULA I Y II DONDE R1- ES N; R2 ES CICLOALQUILO C3-C6, CICLOALQUIL-ALQUILO C6-C10, HETEROCICLOALQUILO C5-C6, ENTRE OTROS; Z ES UN ENLACE O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS 2-(8-METIL-8-AZA-BICICLO[3.2.1]OCT-3-ILIDENO)-1,1-DITIOFEN-2-IL-ETANOL, 2-BENCIL-1-(8-METIL-8-AZA-BICICLO[3.2.1]OCT-3-ILIDENO)-3-FENIL-PROPAN-2-OL, 2-(8-METIL-8-AZA-BICICLO[3.2.1]OCT-3-ILIDENO)-1,1-DITIOFENIL-ETANOL, YODURO DE 3-(2-HIDROXI-2,2-DI-TIOFEN-2-IL-ETILIDENO)-8,8-DIMETIL-8-AZONIA-BICICLO[3.2.1]OCTANO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON ANTAGONISTAS DE RECEPTORES MUSCARINICOS DE LA ACETILCOLINAREFERS TO DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE OF FORMULA I AND II WHERE R1- IS N; R2 IS C3-C6 CYCLOALKYL, C6-C10 CYCLOALKYL-ALKYL, C5-C6 HETERO CYCLOALKYL, AMONG OTHERS; Z IS A LINK OR C1-C6 ALKYL. PREFERRED COMPOUNDS ARE 2- (8-METHYL-8-AZA-BICYCLE [3.2.1] OCT-3-ILIDENE) -1,1-DITIOPHEN-2-IL-ETHANOL, 2-BENZYL-1- (8-METHYL- 8-AZA-BICYCLE [3.2.1] OCT-3-ILIDENE) -3-PHENYL-PROPAN-2-OL, 2- (8-METHYL-8-AZA-BICYCLE [3.2.1] OCT-3-ILIDENE) -1,1-DITIOPHENYL-ETHANOL, IODIDE OF 3- (2-HYDROXY-2,2-DI-THIOFEN-2-IL-ETHYLIDENE) -8,8-DIMETHYL-8-AZONIA-BICICLO [3.2.1] OCTANE , AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS ARE ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS

PE2004001004A 2003-10-17 2004-10-15 DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE AS ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS PE20050442A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51216103P 2003-10-17 2003-10-17

Publications (1)

Publication Number Publication Date
PE20050442A1 true PE20050442A1 (en) 2005-07-09

Family

ID=34465319

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004001004A PE20050442A1 (en) 2003-10-17 2004-10-15 DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE AS ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS

Country Status (22)

Country Link
US (1) US7507747B2 (en)
EP (1) EP1677796A4 (en)
JP (1) JP2007509061A (en)
CN (1) CN1897947A (en)
AP (1) AP2006003575A0 (en)
AR (1) AR046114A1 (en)
AU (1) AU2004281167A1 (en)
BR (1) BRPI0415281A (en)
CA (1) CA2542636A1 (en)
EA (1) EA200600787A1 (en)
EC (1) ECSP066486A (en)
IL (1) IL174846A0 (en)
IS (1) IS8440A (en)
MA (1) MA28109A1 (en)
MX (1) MXPA06004242A (en)
NO (1) NO20062071L (en)
OA (1) OA13270A (en)
PE (1) PE20050442A1 (en)
TW (1) TW200528448A (en)
UY (1) UY28567A1 (en)
WO (1) WO2005037224A2 (en)
ZA (1) ZA200602783B (en)

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AR045914A1 (en) * 2003-07-17 2005-11-16 Glaxo Group Ltd TERTIARY ALCOHOLIC COMPOUND OF 8-AZONIABICICLO [3.2.1] OCTOBER, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE THIS LAST
AR046225A1 (en) * 2003-11-04 2005-11-30 Glaxo Group Ltd COMPOSITE OF 8-AZONIABICICLO (3.2.1) OCTOBER, PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DISEASES MEDIATED BY MUSCARINIC ACETILCOLINE RECEPTORS THAT UNDERSTAND IT AND USE OF THE COMPOUND TO PREPARE SUCH COMPOSITION
WO2005087236A1 (en) * 2004-03-11 2005-09-22 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
US20070185148A1 (en) * 2004-03-17 2007-08-09 Glaxo Group Limited M3 muscarinic acetylchoine receptor antagonists
WO2005095407A1 (en) * 2004-03-17 2005-10-13 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
TWI363759B (en) 2004-04-27 2012-05-11 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
US7598267B2 (en) * 2004-05-13 2009-10-06 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
JP2008520579A (en) * 2004-11-15 2008-06-19 グラクソ グループ リミテッド Novel M3 muscarinic acetylcholine receptor antagonist
EP1937267A4 (en) * 2005-08-02 2009-08-26 Glaxo Group Ltd M3 muscarinic acetylcholine receptor antagonists
EP1937068A4 (en) * 2005-08-18 2010-08-04 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
UY31637A1 (en) 2008-02-06 2009-08-03 DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4
UY31636A1 (en) 2008-02-06 2009-08-03 DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4
TW200946526A (en) 2008-02-06 2009-11-16 Glaxo Group Ltd Dual pharmacophores-PDE4-muscarinic antagonistics
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria

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Also Published As

Publication number Publication date
EP1677796A4 (en) 2006-12-27
NO20062071L (en) 2006-05-08
UY28567A1 (en) 2005-05-31
WO2005037224A3 (en) 2005-06-23
EP1677796A2 (en) 2006-07-12
US20070135478A1 (en) 2007-06-14
CN1897947A (en) 2007-01-17
AP2006003575A0 (en) 2006-04-30
ECSP066486A (en) 2006-10-10
AR046114A1 (en) 2005-11-23
JP2007509061A (en) 2007-04-12
OA13270A (en) 2007-01-31
MXPA06004242A (en) 2006-06-28
BRPI0415281A (en) 2006-12-19
AU2004281167A1 (en) 2005-04-28
IL174846A0 (en) 2006-08-20
ZA200602783B (en) 2007-11-28
TW200528448A (en) 2005-09-01
IS8440A (en) 2006-05-05
WO2005037224A2 (en) 2005-04-28
EA200600787A1 (en) 2006-08-25
MA28109A1 (en) 2006-08-01
CA2542636A1 (en) 2005-04-28
US7507747B2 (en) 2009-03-24

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