PE20040786A1 - Derivados de 7h-dibenzo[b,g][1,5]dioxocin-5-ona como inhibidores de la proteina transportadora del colesterol esterificado (cetp) - Google Patents
Derivados de 7h-dibenzo[b,g][1,5]dioxocin-5-ona como inhibidores de la proteina transportadora del colesterol esterificado (cetp)Info
- Publication number
- PE20040786A1 PE20040786A1 PE2003001096A PE2003001096A PE20040786A1 PE 20040786 A1 PE20040786 A1 PE 20040786A1 PE 2003001096 A PE2003001096 A PE 2003001096A PE 2003001096 A PE2003001096 A PE 2003001096A PE 20040786 A1 PE20040786 A1 PE 20040786A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dioxocin
- ona
- dibenzo
- sterified
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091007403 Cholesterol transporters Proteins 0.000 title 1
- -1 WHERE R1 IS H Chemical class 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- CXTLZNNLRUQOFC-UHFFFAOYSA-N 10,12-dihydrobenzo[b][1,5]benzodioxocine Chemical compound C1OCc2ccccc2Oc2ccccc12 CXTLZNNLRUQOFC-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010021024 Hypolipidaemia Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 208000026621 hypolipoproteinemia Diseases 0.000 abstract 1
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/12—Eight-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A DERIVADOS DE 7H-DIBENZO[b,g][1,5]DIOXOCIN-5-ONA DE FORMULA I, SUS SALES, SOLVATOS Y SOLVATOS DE SALES FARMACEUTICAMENTE ACEPTABLES, EN DONDE R1 ES H, HALOGENO, CIANO, ALQUILO C1-C4, ENTRE OTROS; R2 SON RADICALES DE FORMULAS a, b ENTRE OTROS; R11 ES ALQUILO C1-6 O ALQUENILO C2-C6 OPCIONALMENTE SUSTITUIDOS CON CICLOALQUILO C3-C6, FENILO, ALCOXI C1-C4, ENTRE OTROS; R12 ES H o FORMILO; R13 Y R14 SON ALQUILO C1-C6; R3 Y R4 SON H, HALOGENO, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALQUILO C1-C4, ENTRE OTROS; R5, R6 Y R7 SON H, HALOGENO, CIANO, NITRO, HIDROXI, TRIFLUROMETOXI, ENTRE OTROS; R8 ES ALQUILO C1-C8, ALQUENILO C2-C8 O ALQUINILO C2-C8, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS, DICHOS ALQUILO, ALQUENILO Y ALQUINILO, CON CICLOALQUILO C3-C8, ALCOXI C1-C4, PIRROLILO, IMIDAZOLILO, ENTRE OTROS; R9 Y R10 SON H o ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 3-[(1S)-1-HIDROXI-3-METILBUTIL]-11-(BENCILOXI)-4-METOXI-9-METIL-5H,7H-DIBENZO-[b,g][1,5]DIOXOCIN-5-ONA, 11-(BENCILOXI)-4-METOXI-9-METIL-3-(3-METILBUTANOIL)-5H,7H-DIBENZO-[b,g][1,5]DIOXOCIN-5-ONA, ENTRE OTRAS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PREPRACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENE. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA TRANSPORTADORA DEL COLESTEROL ESTERIFICADO (CETP) Y SON UTILES PARA TRATAR Y/O PREVENIR ENFERMEDADES CARDIOVASCULARES, HIPOLIPOPROTEINEMIA, DISLIPIDEMIAS, HIPERTRIGLICERIDEMIAS, HIPERLIPIDEMIAS Y/O ARTERIOSCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10250687A DE10250687A1 (de) | 2002-10-31 | 2002-10-31 | 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040786A1 true PE20040786A1 (es) | 2004-12-03 |
Family
ID=32103199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001096A PE20040786A1 (es) | 2002-10-31 | 2003-10-30 | Derivados de 7h-dibenzo[b,g][1,5]dioxocin-5-ona como inhibidores de la proteina transportadora del colesterol esterificado (cetp) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060247303A1 (es) |
| EP (1) | EP1560630A2 (es) |
| JP (1) | JP2006508938A (es) |
| AR (1) | AR041723A1 (es) |
| AU (1) | AU2003271734A1 (es) |
| CA (1) | CA2503881A1 (es) |
| DE (1) | DE10250687A1 (es) |
| PE (1) | PE20040786A1 (es) |
| TW (1) | TW200420555A (es) |
| UY (1) | UY28047A1 (es) |
| WO (1) | WO2004039453A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342162A (zh) | 2003-09-26 | 2009-01-14 | 日本烟草产业株式会社 | 抑制残余脂蛋白产生的方法 |
| ATE555097T1 (de) * | 2004-12-18 | 2012-05-15 | Bayer Pharma AG | 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente |
| US7972954B2 (en) * | 2006-01-24 | 2011-07-05 | Infineon Technologies Ag | Porous silicon dielectric |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| CN101298448B (zh) * | 2008-06-27 | 2011-01-05 | 扬州慧清医药科技开发有限公司 | 2-苄氧基-3-乙基-4-甲基-5-氯-6-[(四氢-2h-吡喃-2-氧基)甲基]苯酚的合成方法 |
| CN101298447B (zh) * | 2008-06-27 | 2011-05-25 | 扬州慧清医药科技开发有限公司 | 2-苄氧基-3-乙基-4-甲基-5-氯-6-［(四氢-2h-吡咯-2-氧基)甲基］苯酚的一种合成方法 |
| CN103044383B (zh) * | 2011-10-17 | 2015-01-07 | 复旦大学 | 一种制备天然产物Penicillide消旋体的方法 |
| CN103087040B (zh) * | 2011-11-01 | 2015-10-28 | 复旦大学 | Penicillide衍生物、其制备方法及其在药用用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3919255A1 (de) * | 1989-06-13 | 1990-12-20 | Bayer Ag | Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| JP2710834B2 (ja) * | 1989-07-20 | 1998-02-10 | 社団法人北里研究所 | Ｆｏ―６０８ａ物質およびその製造法 |
| US5198463A (en) * | 1992-03-30 | 1993-03-30 | Merck & Co., Inc. | Oxytocin antagonists |
| JPH06157306A (ja) * | 1992-11-25 | 1994-06-03 | Kokka Iyaku Kanrikyoku Shisen Kokinso Kogyo Kenkyusho | ペニシライド系化合物を有効成分とする脂質低下剤 |
| WO1994018190A1 (fr) * | 1993-02-08 | 1994-08-18 | Taisho Pharmaceutical Co., Ltd. | Compose de depsidone |
-
2002
- 2002-10-31 DE DE10250687A patent/DE10250687A1/de not_active Withdrawn
-
2003
- 2003-10-21 JP JP2004547534A patent/JP2006508938A/ja active Pending
- 2003-10-21 CA CA002503881A patent/CA2503881A1/en not_active Abandoned
- 2003-10-21 US US10/531,881 patent/US20060247303A1/en not_active Abandoned
- 2003-10-21 EP EP03753564A patent/EP1560630A2/de not_active Withdrawn
- 2003-10-21 AU AU2003271734A patent/AU2003271734A1/en not_active Abandoned
- 2003-10-21 WO PCT/EP2003/011619 patent/WO2004039453A2/de not_active Ceased
- 2003-10-24 AR ARP030103895A patent/AR041723A1/es not_active Application Discontinuation
- 2003-10-28 UY UY28047A patent/UY28047A1/es not_active Application Discontinuation
- 2003-10-30 PE PE2003001096A patent/PE20040786A1/es not_active Application Discontinuation
- 2003-10-30 TW TW092130157A patent/TW200420555A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060247303A1 (en) | 2006-11-02 |
| AR041723A1 (es) | 2005-05-26 |
| UY28047A1 (es) | 2004-05-31 |
| DE10250687A1 (de) | 2004-05-13 |
| AU2003271734A1 (en) | 2004-05-25 |
| EP1560630A2 (de) | 2005-08-10 |
| WO2004039453A2 (de) | 2004-05-13 |
| TW200420555A (en) | 2004-10-16 |
| CA2503881A1 (en) | 2004-05-13 |
| JP2006508938A (ja) | 2006-03-16 |
| WO2004039453A3 (de) | 2004-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |