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PE20040775A1 - DERIVADOS DE INDOL COMO AGONISTAS DE ADRENORECEPTORES ß2 - Google Patents

DERIVADOS DE INDOL COMO AGONISTAS DE ADRENORECEPTORES ß2

Info

Publication number
PE20040775A1
PE20040775A1 PE2003001024A PE2003001024A PE20040775A1 PE 20040775 A1 PE20040775 A1 PE 20040775A1 PE 2003001024 A PE2003001024 A PE 2003001024A PE 2003001024 A PE2003001024 A PE 2003001024A PE 20040775 A1 PE20040775 A1 PE 20040775A1
Authority
PE
Peru
Prior art keywords
hydroxy
hydroximethyl
indol
carboxamide
propyl
Prior art date
Application number
PE2003001024A
Other languages
English (en)
Inventor
Alan Daniel Brown
Justin Stephen Bryans
Paul Alan Glossop
Rusell Andrew Lewthwaite
Simon John Mantell
Charlotte Alice Louise Lane
Mark Edward Bunnage
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20020292513 external-priority patent/EP1407769A1/en
Priority claimed from EP03290069A external-priority patent/EP1440966A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20040775A1 publication Critical patent/PE20040775A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE LA FORMULA I DONDE n ES 1 a 4; R1 Y R2 SON H o ALQUILO C1-C4; R3 ES H o ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON UN HIDROXI; R4, R5, R6, R7 y R8 SON H, HIDROXI, ALQUILO C1-C6, ALCOXI C1-C6, BENCILOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-[(2R)-2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)PROPIL]-N-(2-METOXIBENCIL)-1H-INDOL-2-CARBOXAMIDA; 5-[(2R)-2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)PROPIL]-N-(4-(TRIFLUOROMETIL)BENCIL)-1H-INDOL-2-CARBOXAMIDA; N-(2,6-DIMETOXIBENCIL)-5-[(2R)-2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)PROPIL]-1H-INDOL-2-CARBOXAMIDA; 5-[(2R)-2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)PROPIL]-N-(3-METOXIBENCIL)-1H-INDOL-2-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE. DICHOS COMPUESTOS SON AGONISTAS DE RECEPTORES ADRENERGICOS BETA-2 Y SON UTILES PARA TRATAR ENFERMEDADES, TRASTORNOS Y AFECCIONES INFLAMATORIAS, ALERGICAS O RESPIRATORIAS
PE2003001024A 2002-10-11 2003-10-09 DERIVADOS DE INDOL COMO AGONISTAS DE ADRENORECEPTORES ß2 PE20040775A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020292513 EP1407769A1 (en) 2002-10-11 2002-10-11 Indole derivatives as beta-2 agonists
EP03290069A EP1440966A1 (en) 2003-01-10 2003-01-10 Indole derivatives useful for the treatment of diseases

Publications (1)

Publication Number Publication Date
PE20040775A1 true PE20040775A1 (es) 2004-12-10

Family

ID=32095049

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001024A PE20040775A1 (es) 2002-10-11 2003-10-09 DERIVADOS DE INDOL COMO AGONISTAS DE ADRENORECEPTORES ß2

Country Status (25)

Country Link
EP (1) EP1556034B1 (es)
JP (1) JP4490911B2 (es)
KR (1) KR20050047552A (es)
AP (1) AP2005003283A0 (es)
AR (1) AR041566A1 (es)
AT (1) ATE392206T1 (es)
AU (1) AU2003269316A1 (es)
BR (1) BR0315234A (es)
CA (1) CA2499314C (es)
CO (1) CO5550421A2 (es)
DE (1) DE60320439T2 (es)
EA (1) EA200500618A1 (es)
EC (1) ECSP055780A (es)
ES (1) ES2302938T3 (es)
IS (1) IS7751A (es)
MA (1) MA27452A1 (es)
MX (1) MXPA05003866A (es)
NO (1) NO20051406L (es)
OA (1) OA12938A (es)
PA (1) PA8586001A1 (es)
PE (1) PE20040775A1 (es)
PL (1) PL376396A1 (es)
TW (1) TW200424171A (es)
UY (1) UY28013A1 (es)
WO (1) WO2004032921A1 (es)

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US8236808B2 (en) 2008-06-10 2012-08-07 Novartis Ag Pyrazine derivatives as ENAC blockers
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
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PT2379507E (pt) 2008-12-30 2014-01-21 Pulmagen Therapeutics Inflammation Ltd Compostos de sulfonamida para o tratamento de desordens respiratórias
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
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GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
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Also Published As

Publication number Publication date
JP2006511596A (ja) 2006-04-06
MXPA05003866A (es) 2005-06-22
AU2003269316A1 (en) 2004-05-04
CO5550421A2 (es) 2005-08-31
IS7751A (is) 2005-03-17
PL376396A1 (en) 2005-12-27
WO2004032921A1 (en) 2004-04-22
CA2499314C (en) 2010-08-24
ECSP055780A (es) 2005-08-11
OA12938A (en) 2006-10-13
KR20050047552A (ko) 2005-05-20
PA8586001A1 (es) 2005-02-04
UY28013A1 (es) 2004-04-30
BR0315234A (pt) 2005-08-23
JP4490911B2 (ja) 2010-06-30
DE60320439D1 (de) 2008-05-29
EA200500618A1 (ru) 2005-12-29
CA2499314A1 (en) 2004-04-22
ES2302938T3 (es) 2008-08-01
EP1556034A1 (en) 2005-07-27
EP1556034B1 (en) 2008-04-16
NO20051406L (no) 2005-04-22
ATE392206T1 (de) 2008-05-15
MA27452A1 (fr) 2005-07-01
DE60320439T2 (de) 2009-05-20
TW200424171A (en) 2004-11-16
AR041566A1 (es) 2005-05-18
AP2005003283A0 (en) 2005-06-30

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