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PE20040608A1 - Compuestos de alquino con efecto antagonico de la hcm y medicamentos que los contienen - Google Patents

Compuestos de alquino con efecto antagonico de la hcm y medicamentos que los contienen

Info

Publication number
PE20040608A1
PE20040608A1 PE2003001091A PE2003001091A PE20040608A1 PE 20040608 A1 PE20040608 A1 PE 20040608A1 PE 2003001091 A PE2003001091 A PE 2003001091A PE 2003001091 A PE2003001091 A PE 2003001091A PE 20040608 A1 PE20040608 A1 PE 20040608A1
Authority
PE
Peru
Prior art keywords
replaced
hcm
phenyl
compounds
group
Prior art date
Application number
PE2003001091A
Other languages
English (en)
Inventor
Dirk Stenkamp
Stephan Georg Muller
Gerald Jurgen Roth
Thorsten Lehmann-Lintz
Klaus Rudolf
Philipp Lustenberger
Kirsten Arndt
Ralf R H Lotz
Martin Lenter
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040608A1 publication Critical patent/PE20040608A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

SE REFIERE A COMPUESTOS DE ALQUINO DE FORMULA (I) DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C8) O CICLOALQUILO(C3-C7) DONDE UN GRUPO -CH2- PUEDE SER REEMPLAZADO EN LA POSICION 3 O 4 POR -O-, -S- O -NR13-, OJUNTOS PUEDEN FORMAR UN PUENTE ALQUILENO(C2-C8), DONDE 1 O 2 -CH2- PUEDEN ESTAR REEMPLAZADOS POR -CH=N- O -CH=CH- Y/O POR -O-, -S-, -SO-, -(SO2)-, -C=N-R18, -C=N-O-R18, -CO-, -C(=CH2)- O NR13 DE MODO QUE LOS HETEROATOMOS NO ESTEN UNIDOS DIRECTAMENTE; X ES UN ENLACE SIMPLE O UN PUENTE ALQUILENO(C1-C6) DONDE UN -CH2- PUEDE ESTAR REEMPLAZADO POR -CH=CH- O -C*C- Y/O -O-, -S-, -(SO)-, -(SO2)-, -CO- O NR4, DONDE X PUEDE ESTAR UNIDO A R1 INCLUYENDO N FORMANDO UN HETEROCICLICO; W Y Z SON ENLACE SIMPLE O PUENTE ALQUILENO(C1-C4) DONDE UN GRUPO -CH2- NO ADYACENTE AL -C*C- PUEDE SER REEMPLAZADO POR -O- O -NR5-; Y ES Cy, EN DONDE R1 PUEDE ESTAR UNIDO CON Y INCLUYENDO X Y N, FORMANDO UN GRUPO HETEROCICLICO; A Y B TIENE VALORES DE Cy, O B PUEDE SER ALQUILO, ALQUENILO O ALQUINILO(C1-C6), CICLOALQUIL(C3-C7), ENTRE OTROS; Cy ES CARBO- O HETEROCICLICO, SATURADO O NO, DE 3 A 7 MIEMBROS, FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(4-CLORO-FENIL)-2-[5-(2-PIRROLIDIN-1-IL-ETOXI)-PIRID-2-IL-ETINIL]-PIRIDINA, 5-[5-(4-CLORO-FENIL)-PIRIDIN-2-ILETINIL]-1-(2-PIRROLIDIN-1-IL-ETIL)-1,3-DIHIDROBENZIMIDAZOL-2-ONA, ENTRE OTROS. ESTOS COMPUESTOS SON ANTAGONISTAS DE LA HCM (HORMONA CONCENTRADORA DE MELANINA) Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS METABOLICOS Y/O ALIMENTARIOS
PE2003001091A 2002-10-31 2003-10-29 Compuestos de alquino con efecto antagonico de la hcm y medicamentos que los contienen PE20040608A1 (es)

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EP1558578A1 (de) 2005-08-03
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