PE20030387A1 - Derivados de heparinoide y procedimiento para su preparacion - Google Patents
Derivados de heparinoide y procedimiento para su preparacionInfo
- Publication number
- PE20030387A1 PE20030387A1 PE2002000801A PE2002000801A PE20030387A1 PE 20030387 A1 PE20030387 A1 PE 20030387A1 PE 2002000801 A PE2002000801 A PE 2002000801A PE 2002000801 A PE2002000801 A PE 2002000801A PE 20030387 A1 PE20030387 A1 PE 20030387A1
- Authority
- PE
- Peru
- Prior art keywords
- hermitol
- procedure
- aciden
- dpta
- preparation
- Prior art date
Links
- 229920001499 Heparinoid Polymers 0.000 title abstract 2
- 239000002554 heparinoid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WYMDDFRYORANCC-UHFFFAOYSA-N 2-[[3-[bis(carboxymethyl)amino]-2-hydroxypropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)CN(CC(O)=O)CC(O)=O WYMDDFRYORANCC-UHFFFAOYSA-N 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 230000005298 paramagnetic effect Effects 0.000 abstract 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 abstract 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 abstract 1
- -1 PENTOSE POLYSACCHARIDES Chemical class 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- JCSJTDYCNQHPRJ-MMDFAQQLSA-N beta-D-Xylp-(1->4)-beta-D-Xylp-(1->4)-beta-D-Xylp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)OC2)O)OC1 JCSJTDYCNQHPRJ-MMDFAQQLSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 229960000610 enoxaparin Drugs 0.000 abstract 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical compound Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 229960000899 nadroparin Drugs 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
SE REFIERE A DERIVADOS HEPARINOIDES TAL COMO POLISULFATO DE PENTOSANO, SULFATO DE XILANO, DEXTRANO, QUITINA, POLIMEROS DE IDURONA/ACIDOS URONICOS, GLUCOSAMINA, POLISACARIDOS DE PENTOSA, HEXOSA, MANITOL, HEPARANO, HEPARITINA, QUERATANO, DERMATANO, ACIDO HIHALURONICO, SULFATO DE CONDROITINA, ENOXAPARINA, NADROPARINA, FRAXIPARINA, ENTRE OTROS, SE ENCUENTRA UNIDO COVALENTEMENTE AL FORMADOR DE QUELATOS (DIANHIDRIDO DE ACIDO DIETILENTRIAMINA-N,N,N',N",N"-PENTAACETICO DPTA, EDTA, DOTA, NTA, BOPTA, DPDP) Y UN CATION DE METAL PARAMAGNETICO DE METALES DE TRANSICION, LANTANIDOS DE PREFERENCIA CLORURO DE GADOLINIO III; PRESENTANDO UNA ELEVADA ESTABILIDAD Y ESCASA DISOCIACION DEL COMPLEJO CON EL CATION DE METAL PARAMAGNETICO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL DERIVADO PUEDE SER EMPLEADO PARA FINES DIAGNOSTICOS, PARA VIGILANCIA DEL RESULTADO DEL TRATAMIENTO DE ENFERMEDADES COMO TROMBOSIS, OSTEOARTRITIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10141106A DE10141106A1 (de) | 2001-08-22 | 2001-08-22 | Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030387A1 true PE20030387A1 (es) | 2003-05-26 |
Family
ID=7696226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000801A PE20030387A1 (es) | 2001-08-22 | 2002-08-21 | Derivados de heparinoide y procedimiento para su preparacion |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030109491A1 (es) |
| EP (1) | EP1423436B1 (es) |
| JP (1) | JP4426842B2 (es) |
| AT (1) | ATE323109T1 (es) |
| AU (1) | AU2002356085A1 (es) |
| CA (1) | CA2457846A1 (es) |
| DE (2) | DE10141106A1 (es) |
| MX (1) | MXPA04000854A (es) |
| PE (1) | PE20030387A1 (es) |
| WO (1) | WO2003018640A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1537871A1 (en) * | 2003-12-04 | 2005-06-08 | Aventis Pharma S.A. | Enoxaparin for the treatment of cancer |
| AR043110A1 (es) * | 2004-02-04 | 2005-07-20 | Syntex Sa | Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia a |
| CN1269846C (zh) * | 2005-04-20 | 2006-08-16 | 凌沛学 | 肝素银的制备及其应用 |
| US20080214480A1 (en) * | 2005-07-22 | 2008-09-04 | Trf Pharma, Inc. | Method for Treating Sickle Cell Disease and Sickle Cell Disease Sequalae |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| WO2007100541A2 (en) * | 2006-02-23 | 2007-09-07 | Research Foundation Of The State University Of New York | Method of treating periodontitis and of reducing dentinal sensitivity |
| EP2164501B1 (en) * | 2007-05-31 | 2016-04-20 | Paradigm Biopharmaceuticals Limited | Sulphated xylans for treatment or prophylaxis of respiratory diseases |
| EP2182810B1 (en) | 2007-08-03 | 2017-11-08 | Nucitec S.A. de C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
| CA2706250C (en) * | 2007-11-20 | 2018-07-24 | Sasi Kumar Sunkara | Formulation and method for treatment of teeth |
| CN103044349B (zh) * | 2012-12-13 | 2014-05-21 | 浙江大学 | 一种微波辅助纳米铁酸盐制备乙二胺四乙酸酐的方法 |
| EP3337527B1 (en) * | 2015-08-20 | 2020-09-23 | Anteo Technologies Pty Ltd. | Functional coating |
| SG11202001824RA (en) | 2016-08-31 | 2020-04-29 | Oji Holdings Corp | Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide |
| JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
| JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
| US11278485B2 (en) * | 2017-05-31 | 2022-03-22 | Oji Holdings Corporation | Moisturizing topical preparation |
| MX2020002726A (es) | 2017-09-12 | 2020-07-20 | Oji Holdings Corp | Polisulfato de pentosan y metodo para producir polisulfato de pentosan. |
| CN111511773B (zh) | 2017-12-20 | 2023-01-13 | 王子控股株式会社 | 戊聚糖多硫酸酯以及含有戊聚糖多硫酸酯的药物 |
| CN109793751B (zh) * | 2019-01-15 | 2021-02-26 | 广西壮族自治区中国科学院广西植物研究所 | 阿拉伯木聚糖磺酸盐在制备治疗骨关节炎的药物中的应用 |
| CN117224486B (zh) * | 2023-09-26 | 2024-12-13 | 烟台东诚北方制药有限公司 | 一种稳定型那屈肝素钙注射剂及其制备方法 |
| CN117959329A (zh) * | 2024-04-01 | 2024-05-03 | 广东海洋大学 | 一种鱼鳔类肝素化合物在制备双向免疫调节剂中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477318A (en) * | 1980-11-10 | 1984-10-16 | Omi International Corporation | Trivalent chromium electrolyte and process employing metal ion reducing agents |
| AU6621586A (en) * | 1985-11-18 | 1987-06-02 | University Of Texas System, The | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| EP0356435B1 (en) * | 1987-03-19 | 1995-10-18 | Arthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
| WO1990003190A1 (en) * | 1988-09-29 | 1990-04-05 | Ranney David F | Methods and compositions for magnetic resonance imaging |
| FR2663639B1 (fr) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
| US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
| US5783169A (en) * | 1995-07-26 | 1998-07-21 | Brookhaven Science Associates Llc | Rigid bifunctional chelating agents |
| ES2230624T5 (es) * | 1996-11-27 | 2010-10-25 | Aventis Pharmaceuticals Inc. | Composicion farmaceutica que comprende un compuesto que tiene actividad anti-xa y un compuesto antagonista de la agregacion plaquetaria. |
| AU3870099A (en) * | 1998-04-28 | 1999-11-16 | Jagotec Ag | Hyaluronan-based imaging agents |
-
2001
- 2001-08-22 DE DE10141106A patent/DE10141106A1/de not_active Ceased
-
2002
- 2002-08-09 EP EP02796214A patent/EP1423436B1/de not_active Expired - Lifetime
- 2002-08-09 CA CA002457846A patent/CA2457846A1/en not_active Abandoned
- 2002-08-09 DE DE50206406T patent/DE50206406D1/de not_active Expired - Lifetime
- 2002-08-09 AT AT02796214T patent/ATE323109T1/de not_active IP Right Cessation
- 2002-08-09 WO PCT/EP2002/008909 patent/WO2003018640A2/de not_active Ceased
- 2002-08-09 MX MXPA04000854A patent/MXPA04000854A/es unknown
- 2002-08-09 JP JP2003523499A patent/JP4426842B2/ja not_active Expired - Fee Related
- 2002-08-09 AU AU2002356085A patent/AU2002356085A1/en not_active Abandoned
- 2002-08-19 US US10/223,145 patent/US20030109491A1/en not_active Abandoned
- 2002-08-21 PE PE2002000801A patent/PE20030387A1/es not_active Application Discontinuation
-
2008
- 2008-06-19 US US12/142,233 patent/US20080249298A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080249298A1 (en) | 2008-10-09 |
| DE50206406D1 (de) | 2006-05-24 |
| WO2003018640A3 (de) | 2003-11-06 |
| AU2002356085A1 (en) | 2003-03-10 |
| US20030109491A1 (en) | 2003-06-12 |
| EP1423436B1 (de) | 2006-04-12 |
| JP2005501931A (ja) | 2005-01-20 |
| WO2003018640A2 (de) | 2003-03-06 |
| MXPA04000854A (es) | 2004-05-21 |
| EP1423436A2 (de) | 2004-06-02 |
| DE10141106A1 (de) | 2003-03-13 |
| JP4426842B2 (ja) | 2010-03-03 |
| CA2457846A1 (en) | 2003-03-06 |
| ATE323109T1 (de) | 2006-04-15 |
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