PE20030356A1 - ISOXAZOLOPYRIDINONE - Google Patents
ISOXAZOLOPYRIDINONEInfo
- Publication number
- PE20030356A1 PE20030356A1 PE2002000734A PE2002000734A PE20030356A1 PE 20030356 A1 PE20030356 A1 PE 20030356A1 PE 2002000734 A PE2002000734 A PE 2002000734A PE 2002000734 A PE2002000734 A PE 2002000734A PE 20030356 A1 PE20030356 A1 PE 20030356A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- dialkyl
- pidyridin
- ilo
- Prior art date
Links
- XDWKYQRZDNGJNB-UHFFFAOYSA-N chembl246652 Chemical compound C1=2C(=O)NC(C=3C=CC=CC=3)=CC=2ON=C1C1=CC=CC=C1 XDWKYQRZDNGJNB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 4-DIMETHYLAMINOMETHYL-PHENYL Chemical class 0.000 abstract 1
- OFINVCCMFOYTMR-UHFFFAOYSA-N CC1C=C(NO1)C2=CC=CC=C2C3=CC=C(C=C3)COCCOC Chemical compound CC1C=C(NO1)C2=CC=CC=C2C3=CC=C(C=C3)COCCOC OFINVCCMFOYTMR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A ISOXAZOLOPIRIDINONA DE FORMULA I DONDE X ES O; Y ES N O BIEN X ES N E Y ES O; R1 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C7, CARBONO-ALQUILO C1-C4, DIALQUILO C1-C4, ENTRE OTROS; R2 ES ALQUILO C1-C4, CICLOALQUILO C3-C7, BENZO[1,3]DIOXOL-5-ILO, BENZO[1,2,5]OXADIAZOL-5-ILO, ENTRE OTROS; R3 ES H, HALO, ALQUILO C1-C4, DIALQUILO C1-C4, CARBONO-AMINOALQUILO C1-C4, DIALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 6-(4-DIMETILAMINOMETIL-FENIL)-3-FENIL-5H-ISOXAZOLO[4,5-c]PIDIRIDIN-4-ONA EN FORMA DE BASE LIBRE O DE SAL DE ADICION DE ACIDO, 6-(4-(2-METOXI-ETOXIMETIL)-FENIL)-5-METIL-3-FENIL-5H-ISOXAZOLO[4,5-c]PIDIRIDIN-4-ONA EN FORMA DE BASE LIBRE O DE SAL DE ADICION DE ACIDO. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE PARKINSONREFERS TO ISOXAZOLOPYRIDINONE OF FORMULA I WHERE X IS O; Y IS N E OR X IS N E Y IS O; R1 IS H, C1-C4 ALKYL, C3-C7 CYCLOALKYL, CARBON-C1-C4 ALKYL, C1-C4 DIALKYL, AMONG OTHERS; R2 IS C1-C4 ALKYL, C3-C7 CYCLOALKYL, BENZO [1,3] DIOXOL-5-ILO, BENZO [1,2,5] OXADIAZOL-5-ILO, AMONG OTHERS; R3 IS H, HALO, C1-C4 ALKYL, C1-C4 DIALKYL, C1-C4 CARBON-AMINOALKYL, C1-C4 DIALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE 6- (4-DIMETHYLAMINOMETHYL-PHENYL) -3-PHENYL-5H-ISOXAZOLO [4,5-c] PIDYRIDIN-4-ONA IN THE FORM OF A FREE BASE OR ACID ADDITION SALT, 6- (4- (2-METHOXY-ETHOXYMETHYL) -PHENYL) -5-METHYL-3-PHENYL-5H-ISOXAZOLE [4,5-c] PIDYRIDIN-4-ONA IN THE FORM OF A FREE BASE OR A SALT OF ACID ADDITION. IT ALSO REFERS TO A PROCESS FOR THE PREPARATION AND A USEFUL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PARKINSON
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119911.6A GB0119911D0 (en) | 2001-08-15 | 2001-08-15 | Organic Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030356A1 true PE20030356A1 (en) | 2003-05-14 |
Family
ID=9920454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000734A PE20030356A1 (en) | 2001-08-15 | 2002-08-14 | ISOXAZOLOPYRIDINONE |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7087756B2 (en) |
| EP (1) | EP1418912B1 (en) |
| JP (1) | JP2005501847A (en) |
| KR (1) | KR20040029429A (en) |
| CN (1) | CN100384418C (en) |
| AR (1) | AR036351A1 (en) |
| AT (1) | ATE355059T1 (en) |
| BR (1) | BR0211903A (en) |
| CA (1) | CA2454762A1 (en) |
| CO (1) | CO5560566A2 (en) |
| DE (1) | DE60218484T2 (en) |
| EC (1) | ECSP044971A (en) |
| ES (1) | ES2282467T3 (en) |
| GB (1) | GB0119911D0 (en) |
| HU (1) | HUP0401325A3 (en) |
| IL (1) | IL160018A0 (en) |
| MX (1) | MXPA04001419A (en) |
| NO (1) | NO20040659D0 (en) |
| PE (1) | PE20030356A1 (en) |
| PL (1) | PL366848A1 (en) |
| PT (1) | PT1418912E (en) |
| RU (1) | RU2004107847A (en) |
| WO (1) | WO2003015780A2 (en) |
| ZA (1) | ZA200400525B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002102807A1 (en) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | Novel isoxazolopyridone derivatives and uses thereof |
| RU2408589C2 (en) * | 2004-05-14 | 2011-01-10 | Айрм Ллк | Compounds and compositions as modulators of ppar-receptors activated by peroxisome proliferator |
| CA2642672A1 (en) * | 2006-02-16 | 2007-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment of parkinson's disease |
| CA2659155A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1 |
| FR2906250B1 (en) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | DERIVATIVES OF 2-ARYL-6PHENYL-IMIDAZO (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2933609B1 (en) * | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE TREATMENT OF PARKINSON'S DISEASE. |
| EP2376079B1 (en) * | 2009-01-13 | 2016-08-10 | Van Andel Research Institute | Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids |
| FR2950053B1 (en) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | USE OF BENZOIC INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE TREATMENT OF PARKINSON'S DISEASE |
| FR2955110A1 (en) | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | NOVEL BENZOIC PYRROLOPYRIDINE DERIVATIVES |
| DE102011085038A1 (en) | 2011-10-21 | 2013-04-25 | Tesa Se | Method for encapsulating an electronic device |
| HK1222565A1 (en) | 2013-09-25 | 2017-07-07 | 范安德尔研究所 | Highly potent glucocorticoids |
| KR20170033630A (en) | 2015-09-17 | 2017-03-27 | (주)다올 | A boundary block for road |
| ES2945983T3 (en) | 2016-10-14 | 2023-07-11 | Van Andel Res Institute | very potent glucocorticoids |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7602542L (en) | 1975-03-14 | 1976-09-15 | Sandoz Ag | 3- (ALFA-IMINOBENSYL) -4-HYDROXY-2 (LH) -PYRIDONES |
| US4064251A (en) | 1976-06-25 | 1977-12-20 | Sandoz, Inc. | Substituted hydroxy pyridones |
| US4049813A (en) * | 1976-07-15 | 1977-09-20 | Sandoz, Inc. | Substituted isoxazolo pyridinones |
| US4238616A (en) | 1977-01-19 | 1980-12-09 | Sandoz, Inc. | 3-(Substituted)phenyl-5-(β-hydroxyphenethyl)-N-(alkyl)-isoxazole-4-carboxamides |
| DE2801190A1 (en) | 1977-01-19 | 1978-07-20 | Sandoz Ag | 3- (ALPHA-IMINOBENZYL) -4-HYDROXY-2 (1H) - PYRIDONE DERIVATIVE |
| US4113727A (en) * | 1977-04-26 | 1978-09-12 | Sandoz, Inc. | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones |
| JPWO2002102807A1 (en) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | Novel isoxazolopyridone derivatives and uses thereof |
-
2001
- 2001-08-15 GB GBGB0119911.6A patent/GB0119911D0/en not_active Ceased
-
2002
- 2002-08-13 AR ARP020103046A patent/AR036351A1/en unknown
- 2002-08-14 DE DE60218484T patent/DE60218484T2/en not_active Expired - Lifetime
- 2002-08-14 US US10/486,569 patent/US7087756B2/en not_active Expired - Fee Related
- 2002-08-14 PE PE2002000734A patent/PE20030356A1/en not_active Application Discontinuation
- 2002-08-14 HU HU0401325A patent/HUP0401325A3/en unknown
- 2002-08-14 JP JP2003520739A patent/JP2005501847A/en not_active Withdrawn
- 2002-08-14 IL IL16001802A patent/IL160018A0/en unknown
- 2002-08-14 KR KR10-2004-7002124A patent/KR20040029429A/en not_active Ceased
- 2002-08-14 CA CA002454762A patent/CA2454762A1/en not_active Abandoned
- 2002-08-14 PL PL02366848A patent/PL366848A1/en not_active Application Discontinuation
- 2002-08-14 CN CNB028159268A patent/CN100384418C/en not_active Expired - Fee Related
- 2002-08-14 EP EP02772157A patent/EP1418912B1/en not_active Expired - Lifetime
- 2002-08-14 PT PT02772157T patent/PT1418912E/en unknown
- 2002-08-14 MX MXPA04001419A patent/MXPA04001419A/en unknown
- 2002-08-14 BR BR0211903-0A patent/BR0211903A/en not_active IP Right Cessation
- 2002-08-14 WO PCT/EP2002/009134 patent/WO2003015780A2/en not_active Ceased
- 2002-08-14 ES ES02772157T patent/ES2282467T3/en not_active Expired - Lifetime
- 2002-08-14 RU RU2004107847/15A patent/RU2004107847A/en not_active Application Discontinuation
- 2002-08-14 AT AT02772157T patent/ATE355059T1/en not_active IP Right Cessation
-
2004
- 2004-01-23 ZA ZA200400525A patent/ZA200400525B/en unknown
- 2004-02-03 EC EC2004004971A patent/ECSP044971A/en unknown
- 2004-02-13 NO NO20040659A patent/NO20040659D0/en not_active Application Discontinuation
- 2004-03-12 CO CO04023011A patent/CO5560566A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100384418C (en) | 2008-04-30 |
| IL160018A0 (en) | 2004-06-20 |
| BR0211903A (en) | 2004-09-21 |
| NO20040659L (en) | 2004-02-13 |
| ZA200400525B (en) | 2005-04-01 |
| US20040248893A1 (en) | 2004-12-09 |
| AR036351A1 (en) | 2004-09-01 |
| US7087756B2 (en) | 2006-08-08 |
| WO2003015780A3 (en) | 2003-11-13 |
| WO2003015780A2 (en) | 2003-02-27 |
| CA2454762A1 (en) | 2003-02-27 |
| NO20040659D0 (en) | 2004-02-13 |
| ES2282467T3 (en) | 2007-10-16 |
| EP1418912A2 (en) | 2004-05-19 |
| ATE355059T1 (en) | 2006-03-15 |
| PL366848A1 (en) | 2005-02-07 |
| PT1418912E (en) | 2007-05-31 |
| RU2004107847A (en) | 2005-05-10 |
| DE60218484D1 (en) | 2007-04-12 |
| KR20040029429A (en) | 2004-04-06 |
| GB0119911D0 (en) | 2001-10-10 |
| HUP0401325A2 (en) | 2004-10-28 |
| EP1418912B1 (en) | 2007-02-28 |
| CO5560566A2 (en) | 2005-09-30 |
| DE60218484T2 (en) | 2007-11-15 |
| MXPA04001419A (en) | 2004-05-27 |
| ECSP044971A (en) | 2004-03-23 |
| CN1635889A (en) | 2005-07-06 |
| JP2005501847A (en) | 2005-01-20 |
| WO2003015780A8 (en) | 2004-05-21 |
| HUP0401325A3 (en) | 2005-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030356A1 (en) | ISOXAZOLOPYRIDINONE | |
| TWI255807B (en) | Therapeutic agents | |
| MXPA05008172A (en) | Malonamide derivatives as gamma-secretase inhibitors. | |
| PE20081135A1 (en) | DERIVATIVES CONTAINING SULFAMOIL AND THEIR USES | |
| AP1614A (en) | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents. | |
| BRPI0407329A (en) | Pyrimidine Derivatives for the Prevention of HIV Infection | |
| ECSP066383A (en) | DERIVATIVES OF 5-PHENYL-4-METHYL-TIAZOL-2-IL-AMINA AS INHIBITORS OF KINASA ENZYMES PHOSFATIDILINOSITOL 3 (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY ROUTES | |
| PE20050480A1 (en) | [2- (8,9-DIOXO-2,6-DIAZABICYCLO [5.2.0] NON-1 (7) -EN-2-IL) ALKYL] PHOSPHONIC ACID AND DERIVATIVES | |
| TNSN04165A1 (en) | Substituted hydroxyethylamines | |
| PE20060243A1 (en) | DERIVATIVES OF 4-AMINO INSUSTITUTED-5- (4-UREA-PHENYL) -PYRROLOTRIAZINE | |
| PE20120355A1 (en) | PIRAZOLE DERIVATIVES AS INHIBITORS OF THE ENZYME 11ßHSD1 | |
| PE20060589A1 (en) | PHENYLAMINOTIZOLES SUBSTITUTED AS ADENOSINE A1 AND A2b AGONISTS | |
| AU2003284632A1 (en) | Isoquinoline compounds and medicinal use thereof | |
| PE20090210A1 (en) | COMPOUNDS DERIVED FROM PYRAZOLO PYRIMIDINE AS INHIBITORS OF JAK QUINASE | |
| GB0004153D0 (en) | Novel use | |
| MXPA06012640A (en) | Morpholine compounds. | |
| AR040278A1 (en) | GLUCOCORTICOID RECEIVER LINKS FOR THE TREATMENT OF METABOLIC DISORDERS | |
| BR0316908A (en) | Preparation of sterile aqueous suspensions including micronized crystalline inhalation active ingredients | |
| PE20020210A1 (en) | INDOLOQUINAZOLINONES AS POLY INHIBITORS (ADP-RIBOSA) POLYMERASE (PARP) | |
| PE20142421A1 (en) | SUBSTITUTED PHENYLIMIDAZOPYRAZOLES AND THEIR USE | |
| BRPI0518231A2 (en) | 2-starch-4-phenylthiazole derivatives, their preparation and their therapeutic application | |
| SE0302756D0 (en) | Novel Compounds | |
| CY1112638T1 (en) | USE OF INDOLIUM PRODUCERS AS NURR-1 ACTIVATORS FOR RARKINSON'S DISEASE TREATMENT | |
| PE20050393A1 (en) | BENZOPYRANE COMPOUNDS FOR USE IN THE TREATMENT AND PREVENTION OF INFLAMMATION-RELATED CONDITIONS | |
| BR0305041A (en) | Organic compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |