PE20030346A1 - Proceso para la produccion de quinazolinas - Google Patents
Proceso para la produccion de quinazolinasInfo
- Publication number
- PE20030346A1 PE20030346A1 PE2002000678A PE2002000678A PE20030346A1 PE 20030346 A1 PE20030346 A1 PE 20030346A1 PE 2002000678 A PE2002000678 A PE 2002000678A PE 2002000678 A PE2002000678 A PE 2002000678A PE 20030346 A1 PE20030346 A1 PE 20030346A1
- Authority
- PE
- Peru
- Prior art keywords
- ring
- alcoxy
- formula
- members
- quinazolines
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical group [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA PRODUCCION DE QUINAZOLINAS DE FORMULA A DONDE R1 ES ALCOXI C1-C4 SUBSTITUIDO CON ATOMOS DE FLUOR; R2 ES H, ALCOXI C1-C6 SUSTITUIDO CON ATOMOS DE FLUOR; R3 REPRESENTA UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE AL MENOS UN HETEROATOMO SELECCIONADO DE N, 0, S ESTANDO EL ANILLO CON HALO, ALCOXI C1-C4, ALQUILO C1-C4, ENTRE OTROS; R4 ES ANILLO HETEROCICLICO DE 4-7 MIEMBROS CON N, O, S ESTANDO CONDENSADO CON UN ANILLO BENCENO O HETEROCICLICO DE 5 A 6 MIEMBROS CON HETEROATOMOS, ESTANDO OPCIONALMENTE SUSTITUIDO EL SISTEMA DE ANILLO EN CONJUNTO CON UNO O MAS GRUPOS SELECCIONADOS DE OH, ALQUILO C1-C4, ALCOXI C1-C4, HALOGENO, ENTRE OTROS COMPRENDIENDO EL PROCESO CONDENSAR UN COMPUESTO DE FORMULA B CON UN COMPUESTO DE FORMULA NC-N-(R5)(R6) DONDE R5 YR6 JUNTO AL N AL QUE ESTAN UNIDOS REPRESENTAN UN ANILLO HETEROCICLICO CON N DE 4-7 MIEMBROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0118752.5A GB0118752D0 (en) | 2001-08-01 | 2001-08-01 | Process for the production of quinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030346A1 true PE20030346A1 (es) | 2003-04-05 |
Family
ID=9919612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000678A PE20030346A1 (es) | 2001-08-01 | 2002-07-26 | Proceso para la produccion de quinazolinas |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7026479B2 (es) |
| EP (1) | EP1412331B1 (es) |
| JP (1) | JP2005501054A (es) |
| KR (1) | KR20040019097A (es) |
| CN (1) | CN1533378A (es) |
| AP (1) | AP1299A (es) |
| AR (1) | AR036204A1 (es) |
| AT (1) | ATE323677T1 (es) |
| BR (1) | BR0211670A (es) |
| CA (1) | CA2451075A1 (es) |
| CZ (1) | CZ2004151A3 (es) |
| DE (1) | DE60210778T2 (es) |
| DO (1) | DOP2002000443A (es) |
| EG (1) | EG23204A (es) |
| ES (1) | ES2260457T3 (es) |
| GB (1) | GB0118752D0 (es) |
| HN (1) | HN2002000197A (es) |
| HU (1) | HUP0401573A3 (es) |
| IL (1) | IL158998A0 (es) |
| MX (1) | MXPA04000978A (es) |
| PA (1) | PA8550301A1 (es) |
| PE (1) | PE20030346A1 (es) |
| PL (1) | PL368520A1 (es) |
| RU (1) | RU2261861C1 (es) |
| UY (1) | UY27399A1 (es) |
| WO (1) | WO2003011829A1 (es) |
| ZA (1) | ZA200309043B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2280003B1 (en) * | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
| PT2213661E (pt) | 2003-09-26 | 2011-12-15 | Exelixis Inc | Moduladores de c-met e métodos de uso |
| WO2005107758A1 (en) * | 2004-05-06 | 2005-11-17 | Warner-Lambert Company Llc | 4-phenylamino-quinazolin-6-yl-amides |
| DE602007011773D1 (de) * | 2006-08-04 | 2011-02-17 | Merz Pharma Gmbh & Co Kgaa | Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin |
| PL2387563T5 (pl) | 2009-01-16 | 2023-03-13 | Exelixis, Inc. | Sól jabłczanowa N-(4-{[6,7-bis(metyloksy)chinolin-4-ylo]oksy}fenylo-N′-(4-fluorofenylo)cykloproano-1,1-dikarboksyamidu oraz jej krystaliczne postaci do leczenia raka |
| KR101709492B1 (ko) | 2009-03-18 | 2017-02-23 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| IN2012DN00352A (es) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| WO2013082000A1 (en) * | 2011-11-30 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| JP6307087B2 (ja) * | 2012-10-15 | 2018-04-04 | レスバーロジックス コーポレイション | ベンズアミド化合物の合成に有用な化合物 |
| KR102662814B1 (ko) | 2015-03-13 | 2024-05-03 | 리스버로직스 코퍼레이션 | 보체 관련 질환을 치료하기 위한 조성물 및 치료 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719378D0 (en) * | 1987-08-15 | 1987-09-23 | Pfizer Ltd | Antiarrythmic agents |
| US6069149A (en) * | 1997-01-09 | 2000-05-30 | Terumo Kabushiki Kaisha | Amide derivatives and intermediates for the synthesis thereof |
| GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
-
2001
- 2001-08-01 GB GBGB0118752.5A patent/GB0118752D0/en not_active Ceased
-
2002
- 2002-07-11 PA PA20028550301A patent/PA8550301A1/es unknown
- 2002-07-19 RU RU2004102692/04A patent/RU2261861C1/ru not_active IP Right Cessation
- 2002-07-19 PL PL02368520A patent/PL368520A1/xx not_active Application Discontinuation
- 2002-07-19 ES ES02745749T patent/ES2260457T3/es not_active Expired - Lifetime
- 2002-07-19 CA CA002451075A patent/CA2451075A1/en not_active Abandoned
- 2002-07-19 AT AT02745749T patent/ATE323677T1/de not_active IP Right Cessation
- 2002-07-19 MX MXPA04000978A patent/MXPA04000978A/es active IP Right Grant
- 2002-07-19 EP EP02745749A patent/EP1412331B1/en not_active Expired - Lifetime
- 2002-07-19 CZ CZ2004151A patent/CZ2004151A3/cs unknown
- 2002-07-19 HU HU0401573A patent/HUP0401573A3/hu unknown
- 2002-07-19 US US10/199,755 patent/US7026479B2/en not_active Expired - Fee Related
- 2002-07-19 CN CNA028143256A patent/CN1533378A/zh active Pending
- 2002-07-19 WO PCT/IB2002/002872 patent/WO2003011829A1/en not_active Ceased
- 2002-07-19 KR KR10-2004-7001513A patent/KR20040019097A/ko not_active Ceased
- 2002-07-19 JP JP2003517021A patent/JP2005501054A/ja active Pending
- 2002-07-19 BR BR0211670-7A patent/BR0211670A/pt not_active IP Right Cessation
- 2002-07-19 IL IL15899802A patent/IL158998A0/xx unknown
- 2002-07-19 DE DE60210778T patent/DE60210778T2/de not_active Expired - Fee Related
- 2002-07-23 DO DO2002000443A patent/DOP2002000443A/es unknown
- 2002-07-26 PE PE2002000678A patent/PE20030346A1/es not_active Application Discontinuation
- 2002-07-29 EG EG2002070853A patent/EG23204A/xx active
- 2002-07-29 HN HN2002000197A patent/HN2002000197A/es unknown
- 2002-07-29 UY UY27399A patent/UY27399A1/es not_active Application Discontinuation
- 2002-07-31 AR ARP020102914A patent/AR036204A1/es unknown
- 2002-08-01 AP APAP/P/2002/002602A patent/AP1299A/en active
-
2003
- 2003-11-20 ZA ZA200309043A patent/ZA200309043B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60210778D1 (de) | 2006-05-24 |
| DOP2002000443A (es) | 2003-02-15 |
| AP1299A (en) | 2004-09-06 |
| MXPA04000978A (es) | 2004-04-20 |
| JP2005501054A (ja) | 2005-01-13 |
| US20030100753A1 (en) | 2003-05-29 |
| ZA200309043B (en) | 2004-11-22 |
| HN2002000197A (es) | 2003-02-27 |
| BR0211670A (pt) | 2004-07-13 |
| EP1412331A1 (en) | 2004-04-28 |
| ATE323677T1 (de) | 2006-05-15 |
| KR20040019097A (ko) | 2004-03-04 |
| WO2003011829A1 (en) | 2003-02-13 |
| PA8550301A1 (es) | 2003-09-05 |
| CN1533378A (zh) | 2004-09-29 |
| EP1412331B1 (en) | 2006-04-19 |
| HUP0401573A2 (hu) | 2005-01-28 |
| HUP0401573A3 (en) | 2005-06-28 |
| DE60210778T2 (de) | 2007-01-04 |
| PL368520A1 (en) | 2005-04-04 |
| CA2451075A1 (en) | 2003-02-13 |
| EG23204A (en) | 2004-07-31 |
| AR036204A1 (es) | 2004-08-18 |
| US7026479B2 (en) | 2006-04-11 |
| AP2002002602A0 (en) | 2002-09-30 |
| CZ2004151A3 (cs) | 2005-01-12 |
| UY27399A1 (es) | 2003-02-28 |
| ES2260457T3 (es) | 2006-11-01 |
| RU2261861C1 (ru) | 2005-10-10 |
| RU2004102692A (ru) | 2005-07-10 |
| GB0118752D0 (en) | 2001-09-26 |
| IL158998A0 (en) | 2004-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030346A1 (es) | Proceso para la produccion de quinazolinas | |
| FI903331A0 (fi) | Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister. | |
| PE20001551A1 (es) | Derivados de eter biarilico como inhibidores de la recaptacion de monoaminas para el tratamiento de trastornos del snc | |
| ES512702A0 (es) | Procedimiento para preparar una acilanilida. (como desglose y con prioridad de la patente espanola n 502.411, presentada el 22 de mayo de 1981. | |
| NO20040100L (no) | Nye forbindelser som anti-inflammasjons, immunmodulerende og anti-proliferative midler | |
| PE20040120A1 (es) | Derivados de quinolina como antagonistas de npy | |
| DK0997459T3 (da) | Mellemprodukter til fremstilling af retrovirale protease-hæmmere | |
| CR8727A (es) | 4-fenilamino-quinazolin-6-il-amidas | |
| UY29919A1 (es) | Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones | |
| PE20030344A1 (es) | 1-ALQUIL O 1-CICLOALQUIL-TRIAZOLO[4,3-a]QUINAZOLIN-5-ONAS COMO INHIBIDORAS DE FOSFODIESTERASA | |
| PT83713B (pt) | Processo para a preparacao de derivados de 4-benzil-1-(2h)-ftalazinona e de composicoes farmaceuticas que os contem | |
| ES2126097T3 (es) | Derivados de diesteres fosfonicos. | |
| ES2165353T3 (es) | 1-aril-5-(alquilidenimino sustituido)-pirazoles con actividad plaguicida. | |
| ES8705453A1 (es) | Un procedimiento para la preparacion de derivados de cefalosporina. | |
| BR0209950A (pt) | Composição estabilizadora finamente distribuìda para polìmeros contendo halogênio | |
| ES2096973T3 (es) | Fosfazenos que contienen radicales organicos de silicio, proceso para su preparacion, y su empleo. | |
| BR0315840A (pt) | Fosfolipìdeos de anel substituìdo anti-protozoários | |
| BR0213011A (pt) | Processos para a produção de zncl2 a partir de um material primário e/ou secundário contendo zn, e, de zn metálico e cl2 | |
| ES8606283A1 (es) | Procedimiento para preparar derivados de acidos quinolon- carboxilicos | |
| PE15196A1 (es) | Compuesto de di-tert-butifenol util como agente antiinflamatorio | |
| MA26163A1 (fr) | Derives de quinoline substitues par halogene et agent de controle des ectoparasites | |
| ES2046538T3 (es) | Derivados de n-feniltetrahidroindazol. | |
| AR033575A1 (es) | Alcanosulfonatos de fenoxifenilo, un procedimiento para su preparacion, compuestos intermediarios, medicamentos y el uso de dichos compuestos para la preparacion de medicamentos | |
| ES2183500T3 (es) | Nuevos compuestos y composiciones farmaceuticas que los contienen. | |
| PE50296A1 (es) | Eter substituido con tiazol y oxazol biciclico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |