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PE20030278A1 - Derivados de acido aminobencenosulfonico como inhibidor del sistema de intercambio sodio/calcio - Google Patents

Derivados de acido aminobencenosulfonico como inhibidor del sistema de intercambio sodio/calcio

Info

Publication number
PE20030278A1
PE20030278A1 PE2002000650A PE2002000650A PE20030278A1 PE 20030278 A1 PE20030278 A1 PE 20030278A1 PE 2002000650 A PE2002000650 A PE 2002000650A PE 2002000650 A PE2002000650 A PE 2002000650A PE 20030278 A1 PE20030278 A1 PE 20030278A1
Authority
PE
Peru
Prior art keywords
acid
alkyl
aminobenzenosulphonic
sodium
exchange system
Prior art date
Application number
PE2002000650A
Other languages
English (en)
Inventor
Naoya Satoh
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of PE20030278A1 publication Critical patent/PE20030278A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A MEDICAMENTOS QUE COMPRENDEN DERIVADOS DE ACIDO AMINOBENCENOSULFONICO DE FORMULA I, UNA SAL, UN HIDRATO Y UN SOLVATO DEL MISMO DONDE R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, GRUPO ALQUILOHALOGENADO C1-C4, HALOGENO, ARILO C6-C12, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ARALQUILO C7-C12, CON UNO O MAS SUSTITUYENTES SELECCIONADOS DE CIANO, NITRO, ALCOXI C1-C6, HALOGENO, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO 5-METIL-2-[1-PIPERAZINIL)BENCENOSULFONICO, ACIDO 5-TRIFLUOROMETIL-2-[1-PIPERAZINIL)BENCENOSULFONICO, ACIDO 5-n-PROPIL-2-[1-PIPERAZINIL)BENCENOSULFONICO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DEL SISTEMA DE INTERCAMBIO IONICO SODIO/CALCIO Y SON UTILES PARA EL TRATAMIENTO DE LA DISFUNCION RESULTANTE DE LA ISQUEMIA/REPERFUSION
PE2002000650A 2001-07-25 2002-07-24 Derivados de acido aminobencenosulfonico como inhibidor del sistema de intercambio sodio/calcio PE20030278A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001224916 2001-07-25

Publications (1)

Publication Number Publication Date
PE20030278A1 true PE20030278A1 (es) 2003-04-10

Family

ID=19057997

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000650A PE20030278A1 (es) 2001-07-25 2002-07-24 Derivados de acido aminobencenosulfonico como inhibidor del sistema de intercambio sodio/calcio

Country Status (9)

Country Link
US (1) US20040259861A1 (es)
EP (1) EP1409080A1 (es)
JP (1) JP2004538292A (es)
KR (1) KR20040028916A (es)
CN (1) CN100502861C (es)
AR (1) AR034887A1 (es)
CA (1) CA2454681A1 (es)
PE (1) PE20030278A1 (es)
WO (1) WO2003009897A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003261815A1 (en) * 2002-08-30 2004-03-19 Mitsubishi Pharma Corporation Inhibitors for excessive accumulation of sodium ion in cells
JPWO2004022545A1 (ja) * 2002-09-06 2005-12-22 三菱ウェルファーマ株式会社 移植臓器保護剤
JPWO2008010566A1 (ja) * 2006-07-21 2009-12-17 田辺三菱製薬株式会社 ５−メチル‐２‐（ピペラジン−１−イル）ベンゼンスルホン酸の結晶多形
WO2008010567A1 (fr) * 2006-07-21 2008-01-24 Mitsubishi Tanabe Pharma Corporation Sel ou solvate d'acide 5-méthyl-2-(pipérazin-1-yl)benzènesulfonique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0686438B2 (ja) * 1989-03-27 1994-11-02 三菱化成株式会社 アミノベンゼンスルホン酸誘導体
JP3083544B2 (ja) * 1990-09-27 2000-09-04 三菱化学株式会社 心疾患を予防または治療する薬剤
JP3215338B2 (ja) * 1995-12-15 2001-10-02 三菱化学株式会社 アミノベンゼンスルホン酸誘導体一水和物及びその製造方法
CA2192731C (en) * 1995-12-15 2005-09-27 Chika Yamazaki Monohydrates of aminobenzenesulfonic acid derivatives and method for preparing thereof
JPH10298077A (ja) * 1997-04-24 1998-11-10 Mitsubishi Chem Corp 心筋症の治療、予防剤
CN1198617C (zh) * 1998-02-12 2005-04-27 三菱化学株式会社 治疗心脏舒张功能障碍的药物
CN100486574C (zh) * 1999-12-21 2009-05-13 田边三菱制药株式会社 用于神经系统疾病的治疗和/或预防药物

Also Published As

Publication number Publication date
CA2454681A1 (en) 2003-02-06
EP1409080A1 (en) 2004-04-21
WO2003009897A1 (en) 2003-02-06
US20040259861A1 (en) 2004-12-23
JP2004538292A (ja) 2004-12-24
KR20040028916A (ko) 2004-04-03
AR034887A1 (es) 2004-03-24
CN100502861C (zh) 2009-06-24
CN1533292A (zh) 2004-09-29

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