PE20030198A1 - Difumarato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il)piperazina como inhibidor de serina proteasa - Google Patents
Difumarato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il)piperazina como inhibidor de serina proteasaInfo
- Publication number
- PE20030198A1 PE20030198A1 PE2002000496A PE2002000496A PE20030198A1 PE 20030198 A1 PE20030198 A1 PE 20030198A1 PE 2002000496 A PE2002000496 A PE 2002000496A PE 2002000496 A PE2002000496 A PE 2002000496A PE 20030198 A1 PE20030198 A1 PE 20030198A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- diffumarate
- phenylglycinyl
- methylpiperidin
- piperazine
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- -1 INDOL-6-CARBONYL-D-PHENYLGLYCINYL Chemical class 0.000 title abstract 3
- 229940122055 Serine protease inhibitor Drugs 0.000 title 1
- 101710102218 Serine protease inhibitor Proteins 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- KJLFFCRGGGXQKE-UHFFFAOYSA-N 1h-indole-6-carboxamide Chemical compound NC(=O)C1=CC=C2C=CNC2=C1 KJLFFCRGGGXQKE-UHFFFAOYSA-N 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE AL DIFUMARATO DE 1-(INDOL-6-CARBONIL-D-FENILGLICINIL)-4-(1-METILPIPERIDIN-4-IL)PIPERAZINA TAMBIEN SE LE CONOCE COMO 1H-INDOL-6-CARBOXAMIDA, N-[(1R)-2-[4-(1-METIL-4-PIPERIDINIL)-1--PIPERAZINIL]-2-OXO-1-FENILETIL]-(2E)-BUTENODIOATO (1:2), EN FORMA CRISTALINA QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X EN POLVO CON PICOS INTENSOS Y ESTRECHOS A 2 O IGUAL A 6,280, 7,830 Y 19,513. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LA SAL DIFUMARATO QUE ES UN INHIBIDOR SELECTIVO DE LA PROTEASA DE SERINA, FACTOR Xa UTIL PARA COMBATIR UN TRASTORNO TROMBOTICO
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2001/002553 WO2001096323A1 (en) | 2000-06-13 | 2001-06-12 | Serine protease inhibitors |
| US33929501P | 2001-12-12 | 2001-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030198A1 true PE20030198A1 (es) | 2003-03-12 |
Family
ID=41210812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000496A PE20030198A1 (es) | 2001-06-12 | 2002-06-10 | Difumarato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il)piperazina como inhibidor de serina proteasa |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040162295A1 (es) |
| EP (1) | EP1397348B1 (es) |
| JP (1) | JP2004534062A (es) |
| AR (1) | AR036048A1 (es) |
| AT (1) | ATE305452T1 (es) |
| AU (1) | AU2002348501A1 (es) |
| DE (1) | DE60206376T2 (es) |
| ES (1) | ES2248618T3 (es) |
| MY (1) | MY137876A (es) |
| PE (1) | PE20030198A1 (es) |
| SV (1) | SV2003001085A (es) |
| TW (1) | TWI257389B (es) |
| WO (1) | WO2002100847A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003010160A2 (en) * | 2001-07-26 | 2003-02-06 | Eli Lilly And Company | 1-glycinyl-4 (methylpiperidin-4-yl) piperazines and -piperridines as factor xa antagonists |
| EP1492767B1 (en) | 2002-04-01 | 2005-09-07 | Eli Lilly And Company | Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa |
| KR100849242B1 (ko) * | 2004-06-30 | 2008-07-29 | 일라이 릴리 앤드 캄파니 | 1(인돌-6-카르보닐-ｄ-페닐글리시닐)-4-(1-메틸피페리딘-4-일) 피페라진 ｄ-타르트레이트 |
| EP1763521A1 (en) * | 2004-06-30 | 2007-03-21 | Eli Lilly and Company | 1- (indole-6-carbonyl-d-phenylglycinyl)-4- (l-methylpiperidin-4- yl) piperazine d-tartrate |
| DE102007028407A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028319A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028406A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| JP2015524400A (ja) * | 2012-07-19 | 2015-08-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5414000A (en) * | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
-
2002
- 2002-06-05 TW TW091112134A patent/TWI257389B/zh not_active IP Right Cessation
- 2002-06-06 ES ES02778933T patent/ES2248618T3/es not_active Expired - Lifetime
- 2002-06-06 EP EP02778933A patent/EP1397348B1/en not_active Expired - Lifetime
- 2002-06-06 US US10/477,192 patent/US20040162295A1/en not_active Abandoned
- 2002-06-06 JP JP2003503615A patent/JP2004534062A/ja active Pending
- 2002-06-06 AU AU2002348501A patent/AU2002348501A1/en not_active Abandoned
- 2002-06-06 AT AT02778933T patent/ATE305452T1/de not_active IP Right Cessation
- 2002-06-06 DE DE60206376T patent/DE60206376T2/de not_active Expired - Fee Related
- 2002-06-06 WO PCT/US2002/016569 patent/WO2002100847A2/en not_active Ceased
- 2002-06-10 MY MYPI20022155A patent/MY137876A/en unknown
- 2002-06-10 PE PE2002000496A patent/PE20030198A1/es not_active Application Discontinuation
- 2002-06-11 SV SV2002001085A patent/SV2003001085A/es not_active Application Discontinuation
- 2002-06-11 AR ARP020102199A patent/AR036048A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR036048A1 (es) | 2004-08-04 |
| EP1397348A2 (en) | 2004-03-17 |
| ATE305452T1 (de) | 2005-10-15 |
| ES2248618T3 (es) | 2006-03-16 |
| AU2002348501A1 (en) | 2002-12-23 |
| DE60206376D1 (de) | 2006-02-09 |
| SV2003001085A (es) | 2003-03-18 |
| DE60206376T2 (de) | 2006-06-22 |
| JP2004534062A (ja) | 2004-11-11 |
| WO2002100847A3 (en) | 2003-08-21 |
| TWI257389B (en) | 2006-07-01 |
| WO2002100847A2 (en) | 2002-12-19 |
| EP1397348B1 (en) | 2005-09-28 |
| US20040162295A1 (en) | 2004-08-19 |
| MY137876A (en) | 2009-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |