PE20030190A1 - Conjugados de complejos metalicos macrociclicos con biomoleculas y preparacion de medios de diagnostico que los contienen para resonancia magnetica nuclear, radiodiagnostico y radioterapiaradiodiagnostico y radioterapia - Google Patents
Conjugados de complejos metalicos macrociclicos con biomoleculas y preparacion de medios de diagnostico que los contienen para resonancia magnetica nuclear, radiodiagnostico y radioterapiaradiodiagnostico y radioterapiaInfo
- Publication number
- PE20030190A1 PE20030190A1 PE2002000641A PE2002000641A PE20030190A1 PE 20030190 A1 PE20030190 A1 PE 20030190A1 PE 2002000641 A PE2002000641 A PE 2002000641A PE 2002000641 A PE2002000641 A PE 2002000641A PE 20030190 A1 PE20030190 A1 PE 20030190A1
- Authority
- PE
- Peru
- Prior art keywords
- radical
- atoms
- conjugates
- optionally
- unsaturated
- Prior art date
Links
- 238000005481 NMR spectroscopy Methods 0.000 title 1
- 238000001959 radiotherapy Methods 0.000 title 1
- -1 CARBOXYL GROUP Chemical group 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000001455 metallic ions Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
CONJUGADOS DE FORMULA (I), DONDE Z ES H O AL MENOS DOS Z SON UN EQUIVALENTE DE UN ION METALICO; B ES H O UN RADICAL ALQUILO C1-4; R ES H O UN RADICAL ALQUILO C1-10 O ARILO LINEAL RAMIFICADO O CICLICO, SATURADO O INSATURADO SUSTITUIDO OPCIONALMENTE POR UN GRUPO CARBOXILO, -SO3H o -PO3H2; DONDE, LA CADENA C1-10 CONTIENE UN GRUPO ARILO Y/O 1 A 2 ATOMOS DE OXIGENO Y LOS RADICALES B Y R NO REPRESENTAN AL MISMO TIEMPO ATOMOS DE OXIGENO; A ES UNA CADENA DE HIDROCARBUROS C1-30 LINEAL O RAMIFICADA, SATURADA O INSATURADA, QUE TIENE OPCIONALMENTE 1 A 5 ATOMOS DE OXIGENO, 1 A 5 ATOMOS DE NITROGENO Y/O 1 A 5 RADICALES -NR´, DONDE R´ ESTA DEFINIDO COMO R, PERO PUEDE SELECCIONARSE DE MODO INDEPENDIENTE, QUE ESTA OPCIONALMENTE SUSTITUIDO CON 1 A 3 GRUPOS CARBOXILO, 1 A 3 -SO3H, 1 A 3 -PO3H2 Y/O 1 A 3 ATOMOS DE HALOGENO, DONDE ESTAN PRESENTES OPCIONALMENTE 1 A 3 ATOMOS DE C, COMO GRUPOS CARBONILO, ESTANDO A O UNA PARTE DE A DISPUESTA EN FORMA DE ANILLO Y CONFORMADA DE MODO TAL QUE X´ ESTA ENLAZADO A TRAVES DE 3 ATOMOS CON EL ATOMO DE NITROGENO AL QUE ESTA UNIDO A; X´ ES EL RADICAL DE UN GRUPO X QUE REACCIONO CON UNA BIOMOLECULA; Y, Bio ES EL RADICAL DE UNA BIOMOLECULA, SUS SALES CON LA CONDICION DE QUE CUANDO B ES H Y R ES C1-4, A NO ES EL RADICAL DE FOMULA (II), SIENDO R3 UN ATOMO DE H O UN RADICAL ALQUILO C1-4; D ES ALQUILENO C1-4 LINEAL O RAMIFICADO, SATURADO O INSATURADO QUE PUEDE SER SUSTITUIDO POR UN GRUPO CARBONILO Y D ESTA UNIDO A X
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10135355A DE10135355C1 (de) | 2001-07-20 | 2001-07-20 | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030190A1 true PE20030190A1 (es) | 2003-03-22 |
Family
ID=7692470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000641A PE20030190A1 (es) | 2001-07-20 | 2002-07-19 | Conjugados de complejos metalicos macrociclicos con biomoleculas y preparacion de medios de diagnostico que los contienen para resonancia magnetica nuclear, radiodiagnostico y radioterapiaradiodiagnostico y radioterapia |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20030206865A1 (es) |
| EP (1) | EP1450864A2 (es) |
| JP (1) | JP2004536889A (es) |
| KR (1) | KR20040030825A (es) |
| CN (1) | CN1301750C (es) |
| AR (1) | AR036182A1 (es) |
| AU (1) | AU2002355333B2 (es) |
| BR (1) | BR0211150A (es) |
| CA (1) | CA2453214A1 (es) |
| DE (1) | DE10135355C1 (es) |
| IL (1) | IL159291A0 (es) |
| MX (1) | MXPA04000400A (es) |
| NO (1) | NO20040239L (es) |
| PE (1) | PE20030190A1 (es) |
| PL (1) | PL366421A1 (es) |
| RU (1) | RU2004105262A (es) |
| TW (1) | TWI238722B (es) |
| UY (1) | UY27389A1 (es) |
| WO (1) | WO2003013617A2 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US7067111B1 (en) | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| KR100784120B1 (ko) * | 2000-06-02 | 2007-12-12 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 에틸렌디시스테인(ｅｃ)-약물 접합체 |
| DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| EP1466629A1 (en) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
| DE10325752A1 (de) * | 2003-06-06 | 2004-12-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Lektin-Konjugate |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| JP2007521254A (ja) * | 2003-06-25 | 2007-08-02 | ゲルベ | 診断画像用化合物 |
| EP1687034A1 (en) * | 2003-11-17 | 2006-08-09 | Philips Intellectual Property & Standards GmbH | Contrast agent for medical imaging techniques and usage thereof |
| US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
| FR2868320B1 (fr) * | 2004-03-31 | 2007-11-02 | Centre Nat Rech Scient Cnrse | Agent de contraste pour l'imagerie par resonance magnetique |
| WO2006039505A2 (en) | 2004-09-30 | 2006-04-13 | Molecular Devices Corporation | Luminescent lanthanide complexes |
| CN101166547B (zh) * | 2005-04-26 | 2013-02-06 | 皇家飞利浦电子股份有限公司 | 包含cest活性的顺磁性配合物的mri造影剂 |
| FI20055712A0 (fi) * | 2005-12-29 | 2005-12-29 | Wallac Oy | Makrosykliset oligonukleotiidien leimausreagenssit ja niistä johdetut konjugaatit |
| US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| JP2011509304A (ja) | 2008-01-09 | 2011-03-24 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 炭酸脱水酵素ｉｘの阻害剤 |
| AU2009322171A1 (en) | 2008-12-05 | 2011-06-30 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
| US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
| US8465725B2 (en) | 2009-06-15 | 2013-06-18 | Molecular Insight Pharmaceuticlas, Inc. | Process for production of heterodimers of glutamic acid |
| CN101912623B (zh) * | 2010-08-24 | 2012-06-06 | 上海师范大学 | 具有靶向功能铁-钆双模式磁共振造影剂的制备及应用 |
| CN102136339B (zh) * | 2011-01-24 | 2012-05-23 | 南开大学 | 一种具有铁磁、铁电双功能的镝单分子磁体及其制备方法 |
| CA2860504A1 (en) | 2012-01-06 | 2013-07-11 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase ix |
| ES2738474T3 (es) | 2013-01-14 | 2020-01-23 | Molecular Insight Pharm Inc | Radiofármacos a base de triazina y agentes radioimagenológicos |
| EP3074388A1 (en) * | 2013-11-25 | 2016-10-05 | Sanofi | Dotam derivatives for therapeutic use |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| US11191854B2 (en) | 2017-05-05 | 2021-12-07 | Centre For Probe Development And Commercialization | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| IL313115A (en) | 2017-05-05 | 2024-07-01 | Centre For Probe Dev And Commercialization | R1–IGF monoclonal antibodies and their use |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| AU2019382881B2 (en) | 2018-11-23 | 2025-06-12 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
| FR3092580B1 (fr) * | 2019-02-08 | 2021-03-19 | Centre Nat Rech Scient | Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes |
| EP3757098A1 (en) * | 2019-06-25 | 2020-12-30 | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. | Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof |
| KR102203368B1 (ko) * | 2020-10-30 | 2021-01-14 | 경북대학교 산학협력단 | 신규한 화합물 및 이를 함유하는 mri 조영제 |
| US20250154159A1 (en) * | 2022-03-16 | 2025-05-15 | Wenzhou Institute University of Chinese Academy of Sciences | CYCLIC Gd (III) COMPLEX AND PREPARATION METHOD AND USE THEREOF |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049667A (en) * | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
| JPH04154729A (ja) * | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
| DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| CA2092596A1 (en) * | 1992-03-27 | 1993-09-28 | Kan Kubomura | Tetraazacyclododecane derivative and its use |
| DE69324161T2 (de) * | 1992-12-09 | 1999-10-28 | Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield | Stabilisierte medizinische aerosollösungen |
| US6693190B1 (en) * | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
| US6045776A (en) * | 1996-12-04 | 2000-04-04 | Schering Aktiengesellschaft | Process for the production of metal-complex carboxylic acid amides |
| US6113880A (en) * | 1997-12-17 | 2000-09-05 | Schering Aktiengesellschaft | Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging |
| DE19905094C1 (de) * | 1999-02-01 | 2000-10-12 | Schering Ag | Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel |
-
2001
- 2001-07-20 DE DE10135355A patent/DE10135355C1/de not_active Expired - Fee Related
-
2002
- 2002-07-17 UY UY27389A patent/UY27389A1/es not_active Application Discontinuation
- 2002-07-18 JP JP2003518619A patent/JP2004536889A/ja active Pending
- 2002-07-18 EP EP02794507A patent/EP1450864A2/de not_active Withdrawn
- 2002-07-18 WO PCT/EP2002/008000 patent/WO2003013617A2/de not_active Ceased
- 2002-07-18 RU RU2004105262/04A patent/RU2004105262A/ru not_active Application Discontinuation
- 2002-07-18 IL IL15929102A patent/IL159291A0/xx unknown
- 2002-07-18 AU AU2002355333A patent/AU2002355333B2/en not_active Ceased
- 2002-07-18 PL PL02366421A patent/PL366421A1/xx not_active Application Discontinuation
- 2002-07-18 MX MXPA04000400A patent/MXPA04000400A/es not_active Application Discontinuation
- 2002-07-18 BR BR0211150-0A patent/BR0211150A/pt not_active IP Right Cessation
- 2002-07-18 KR KR10-2004-7000905A patent/KR20040030825A/ko not_active Ceased
- 2002-07-18 CN CNB028145690A patent/CN1301750C/zh not_active Expired - Fee Related
- 2002-07-18 CA CA002453214A patent/CA2453214A1/en not_active Abandoned
- 2002-07-19 PE PE2002000641A patent/PE20030190A1/es not_active Application Discontinuation
- 2002-07-19 TW TW091116146A patent/TWI238722B/zh not_active IP Right Cessation
- 2002-07-19 AR ARP020102718A patent/AR036182A1/es unknown
- 2002-07-19 US US10/198,048 patent/US20030206865A1/en not_active Abandoned
-
2004
- 2004-01-19 NO NO20040239A patent/NO20040239L/no not_active Application Discontinuation
-
2006
- 2006-03-28 US US11/390,414 patent/US20070014725A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002355333B2 (en) | 2007-01-04 |
| UY27389A1 (es) | 2003-02-28 |
| WO2003013617A3 (de) | 2004-06-10 |
| PL366421A1 (en) | 2005-01-24 |
| NO20040239L (no) | 2004-01-19 |
| MXPA04000400A (es) | 2004-03-18 |
| US20030206865A1 (en) | 2003-11-06 |
| RU2004105262A (ru) | 2005-07-10 |
| US20070014725A1 (en) | 2007-01-18 |
| DE10135355C1 (de) | 2003-04-17 |
| WO2003013617A2 (de) | 2003-02-20 |
| EP1450864A2 (de) | 2004-09-01 |
| CA2453214A1 (en) | 2003-02-20 |
| IL159291A0 (en) | 2004-06-01 |
| CN1541114A (zh) | 2004-10-27 |
| KR20040030825A (ko) | 2004-04-09 |
| JP2004536889A (ja) | 2004-12-09 |
| BR0211150A (pt) | 2004-06-29 |
| AR036182A1 (es) | 2004-08-18 |
| TWI238722B (en) | 2005-09-01 |
| CN1301750C (zh) | 2007-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |