PE20030125A1 - PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS - Google Patents
PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOSInfo
- Publication number
- PE20030125A1 PE20030125A1 PE2002000449A PE2002000449A PE20030125A1 PE 20030125 A1 PE20030125 A1 PE 20030125A1 PE 2002000449 A PE2002000449 A PE 2002000449A PE 2002000449 A PE2002000449 A PE 2002000449A PE 20030125 A1 PE20030125 A1 PE 20030125A1
- Authority
- PE
- Peru
- Prior art keywords
- antibacterial agents
- formula
- pirido
- pyrimidine
- compounds
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A PIRIDO[1,2-c]PIRIMIDINA COMO AGENTE ANTIBACTERIANO DE FORMULA I DONDE R1 ES H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C2-C7, CICLOALQUILO C3-C7, ARILO, HETEROCICLO, HETEROARILO; R2 ES R1, HALO, NO2, NO, CN, OC(=O)Ra, COORb, COSRb; CONRcRd, NReRf; Ra, Rb, Rc, Rd, Re, Rf SON H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C1-C7, CICLOALQUILO C3-C7, ARILO, HETEROCICLO, ENTRE OTROS, R3, R4, R6 SON H, OH, (O)n-ALQUILO C1-C7, (O)n-ALQUENILO C2-C7, (O)n-ALQUINILO C2-C7, HALO, NO2, CN, NReRf; R1 Y R6 FORMAN UN ANILLO DE 4-8 MIEMBROS; n ES 0-1; R1 Y R6 JUNTOS FORMAN UN ANILLO DE 5-8 MIEMBROS; R5 ES H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C2-C7, OC(=0)ORb, COORb, COSRb, SO2Rb, ENTRE OTROS; J Y K SON C, N; O CUANDO J o K ES N, R4, R6 ESTAN AUSENTES. SON COMPUESTOS PREFERIDOS 2-AMINO-4-CICLOPROPIL-7-FLUORO-5-METIL-6-[3-(1-METILAMINOETIL)PIRROLIDIN-1-IL]-PIRIDO[1,2-c]PIRIMIDIN-1,3-DIONA, ESTER TERCBUTILICO DEL ACIDO {1-[1-(2-AMINO-4-CICLOPROPIL-7-FLUORO-5-METIL-1,3-DIOXO-2,3-DIHIDRO-1H-PIRIDO-[1,2-c]-PIRIMIDIN-6-IL)-4-METILPIRROLIDIN-3-IL]-ETIL}CARBAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE DNA-GIRASA O TOPOISOMERASA IV BACTERIANA RESISTENTE A QUINOLONAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29433801P | 2001-05-30 | 2001-05-30 | |
| US36507702P | 2002-03-19 | 2002-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030125A1 true PE20030125A1 (es) | 2003-02-12 |
Family
ID=31720253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000449A PE20030125A1 (es) | 2001-05-30 | 2002-05-28 | PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6864259B2 (es) |
| EP (1) | EP1395585B1 (es) |
| JP (1) | JP2004532876A (es) |
| AT (1) | ATE315038T1 (es) |
| BR (1) | BR0210099A (es) |
| DE (1) | DE60208541D1 (es) |
| HN (1) | HN2002000111A (es) |
| MX (1) | MXPA03010799A (es) |
| PE (1) | PE20030125A1 (es) |
| SV (1) | SV2003001058A (es) |
| UY (1) | UY27311A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10214257A1 (de) * | 2002-03-28 | 2003-10-16 | Merck Patent Gmbh | Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden |
| DOP2006000268A (es) * | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
| JP5175984B2 (ja) * | 2009-11-13 | 2013-04-03 | 公益財団法人微生物化学研究会 | キノロン類耐性菌用抗菌剤及びその用途 |
| CN116693394A (zh) * | 2023-04-16 | 2023-09-05 | 大连理工大学 | 一种脱肼方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3068648D1 (de) | 1980-03-10 | 1984-08-30 | Berri Balzac | Derivatives of 3-amino-(1h,3h)-2,4-quinazolin-diones |
| GB2097784A (en) | 1981-04-28 | 1982-11-10 | Davidson Dr John Stirton | Dihydrobenzotriazepine diones; aminoquinazoline diones |
| AU5813394A (en) | 1992-12-23 | 1994-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
| US5670506A (en) | 1993-04-05 | 1997-09-23 | Cell Therapeutics, Inc. | Halogen, isothiocyanate or azide substituted xanthines |
| BR9407806A (pt) | 1993-10-14 | 1997-08-19 | Abbott Lab | Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético |
| AU6908398A (en) | 1996-10-28 | 1998-05-22 | Versicor Inc | Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones |
| SI1028950T1 (en) | 1997-10-28 | 2003-08-31 | Warner-Lambert Company Llc | 7-substituted quinazolin-2,4-diones useful as antibacterial agents |
| KR20010043829A (ko) | 1998-05-26 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세포 증식 억제제로서의 비시클릭 피리미딘 및 비시클릭3,4-디히드로피리미딘 |
| EA005585B1 (ru) | 2000-01-24 | 2005-04-28 | Уорнер-Ламберт Компани | 3-аминохиназолин-2,4-дионовые антибактериальные агенты |
-
2002
- 2002-05-01 MX MXPA03010799A patent/MXPA03010799A/es unknown
- 2002-05-01 BR BR0210099-1A patent/BR0210099A/pt not_active IP Right Cessation
- 2002-05-01 DE DE60208541T patent/DE60208541D1/de not_active Expired - Lifetime
- 2002-05-01 AT AT02727861T patent/ATE315038T1/de not_active IP Right Cessation
- 2002-05-01 EP EP02727861A patent/EP1395585B1/en not_active Expired - Lifetime
- 2002-05-01 JP JP2003500087A patent/JP2004532876A/ja not_active Withdrawn
- 2002-05-08 HN HN2002000111A patent/HN2002000111A/es unknown
- 2002-05-27 UY UY27311A patent/UY27311A1/es not_active Application Discontinuation
- 2002-05-28 PE PE2002000449A patent/PE20030125A1/es not_active Application Discontinuation
- 2002-05-29 SV SV2002001058A patent/SV2003001058A/es unknown
- 2002-05-29 US US10/157,370 patent/US6864259B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6864259B2 (en) | 2005-03-08 |
| EP1395585B1 (en) | 2006-01-04 |
| HN2002000111A (es) | 2002-07-08 |
| EP1395585A1 (en) | 2004-03-10 |
| US20030114458A1 (en) | 2003-06-19 |
| JP2004532876A (ja) | 2004-10-28 |
| ATE315038T1 (de) | 2006-02-15 |
| BR0210099A (pt) | 2004-04-13 |
| DE60208541D1 (de) | 2006-03-30 |
| MXPA03010799A (es) | 2005-07-25 |
| UY27311A1 (es) | 2002-12-31 |
| SV2003001058A (es) | 2003-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |