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PE20030929A1 - 3- (IMIDAZOLIL) -2-ALCOXYPROPANOIC ACIDS - Google Patents

3- (IMIDAZOLIL) -2-ALCOXYPROPANOIC ACIDS

Info

Publication number
PE20030929A1
PE20030929A1 PE2003000058A PE2003000058A PE20030929A1 PE 20030929 A1 PE20030929 A1 PE 20030929A1 PE 2003000058 A PE2003000058 A PE 2003000058A PE 2003000058 A PE2003000058 A PE 2003000058A PE 20030929 A1 PE20030929 A1 PE 20030929A1
Authority
PE
Peru
Prior art keywords
alkyl
imidazol
acid
alcoxypropanoic
imidazolil
Prior art date
Application number
PE2003000058A
Other languages
Spanish (es)
Inventor
David John Bull
Mark Edward Bunnage
Robert John Maguire
John Steele
Charlotte Moira Norfor Allerton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0201389A external-priority patent/GB0201389D0/en
Priority claimed from GB0202027A external-priority patent/GB0202027D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20030929A1 publication Critical patent/PE20030929A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A ACIDOS 3-(IMIDAZOLIL)-2-ALCOXIPROPANOICOS DE FORMULA I DONDE n ES 0-3; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ARILO, HETEROCICLO AROMATICO, ENTRE OTROS; R2, R3, R4, R6, R7 Y R9 SON H, ALQUILO C1-C6 DE CADENA LINEAL O RAMIFICADA CON OR10, HALO; R5 Y R8 SON H, ALQUILO C1-C6 DE CADENA LINEAL O RAMIFICADA; R10 ES H, ALQUILO C1-C6, ARILO. SON COMPUESTOS PREFERIDOS ACIDO (2S)-(-)-2-(2-AMINOETOXI)-3-(1-FENIL-1H-IMIDAZOL-4-IL)PROPANOICO, ACIDO (2S)-2-{((1R)-2-AMINO-1-METILETIL]OXI}-3-(1-(2-CICLOHEXILETIL)-1H-IMIDAZOL-4-IL)PROPANOICO, ACIDO (2S)-2-{((1R)-2-AMINO-1-METILETIL]OXI}-3-(1-FENIL-1H-IMIDAZOL-4-IL)PROPANOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON UTILES EN EL TRATAMIENTO DE AFECCIONES TROMBOTICAS Y PATOLOGIAS ASOCIADAS CON LA DEPOSICION DE FIBRINAREFERS TO 3- (IMIDAZOLIL) -2-ALCOXYPROPANOIC ACIDS OF FORMULA I WHERE n IS 0-3; R1 IS C1-C6 ALKYL, C2-C6 ALKYL, C2-C6 ALKYL, ARYL, AROMATIC HETEROCYCLE, AMONG OTHERS; R2, R3, R4, R6, R7 AND R9 ARE H, C1-C6 ALKYL OF LINEAR OR BRANCHED CHAIN WITH OR10, HALO; R5 AND R8 ARE H, C1-C6 RENTAL OF LINEAR OR BRANCHED CHAIN; R10 IS H, C1-C6 ALKYL, ARYL. THE PREFERRED COMPOUNDS ARE ACID (2S) - (-) - 2- (2-AMINOETOXY) -3- (1-PHENYL-1H-IMIDAZOL-4-IL) PROPANOIC, ACID (2S) -2 - {((1R) - 2-AMINO-1-METHYLETHYL] OXY} -3- (1- (2-CYCLOHEXYLETHYL) -1H-IMIDAZOL-4-IL) PROPANOIC ACID (2S) -2 - {((1R) -2-AMINO-1 -METILETIL] OXI} -3- (1-PHENYL-1H-IMIDAZOL-4-IL) PROPANOICO, AMONG OTHERS, REFERS ALSO TO A PHARMACEUTICAL COMPOSITION AND A PROCEDURE FOR THE PREPARATION. THE MENTIONED COMPOUNDS ARE USEFUL IN THE TREATMENT OF AFFECTIONS THROMBOTIC AND PATHOLOGIES ASSOCIATED WITH FIBRIN DEPOSITION

PE2003000058A 2002-01-22 2003-01-17 3- (IMIDAZOLIL) -2-ALCOXYPROPANOIC ACIDS PE20030929A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0201389A GB0201389D0 (en) 2002-01-22 2002-01-22 3-(imidazolyl)-2-alkoxypropanoic acids
GB0202027A GB0202027D0 (en) 2002-01-29 2002-01-29 3-(imidazolyl)-2-alkoxypropanoic acids

Publications (1)

Publication Number Publication Date
PE20030929A1 true PE20030929A1 (en) 2003-11-05

Family

ID=27614792

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000058A PE20030929A1 (en) 2002-01-22 2003-01-17 3- (IMIDAZOLIL) -2-ALCOXYPROPANOIC ACIDS

Country Status (24)

Country Link
EP (1) EP1467731A1 (en)
JP (1) JP2005520811A (en)
KR (1) KR20040077775A (en)
CN (1) CN1620291A (en)
AP (1) AP2004003084A0 (en)
AR (1) AR038197A1 (en)
BR (1) BR0307016A (en)
CA (1) CA2472238A1 (en)
EA (1) EA200400716A1 (en)
EC (1) ECSP045200A (en)
HR (1) HRP20040659A2 (en)
IL (1) IL162677A0 (en)
IS (1) IS7310A (en)
MA (1) MA27167A1 (en)
MX (1) MXPA04006573A (en)
NO (1) NO20043457L (en)
OA (1) OA12756A (en)
PA (1) PA8563501A1 (en)
PE (1) PE20030929A1 (en)
PL (1) PL371487A1 (en)
TN (1) TNSN04121A1 (en)
TW (1) TW200302094A (en)
UY (1) UY27615A1 (en)
WO (1) WO2003061652A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051384A1 (en) * 2003-11-25 2005-06-09 Pfizer Limited Stabilised pharmaceutical compositions
JP2008536923A (en) * 2005-04-18 2008-09-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト Use of TAFI inhibitors to enhance myocardial reperfusion and facilitate PCI
US20110213143A1 (en) 2008-10-29 2011-09-01 Taisho Pharmaceutical Co., Ltd. Compound having tafia inhibitory activity
US8987242B2 (en) 2008-12-05 2015-03-24 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXA inhibitors
EP2373634B1 (en) * 2008-12-05 2015-11-11 Mochida Pharmaceutical Co., Ltd. Morpholinone compounds as factor ixa inhibitors
EP2548872B1 (en) 2010-03-18 2016-09-28 Daiichi Sankyo Company, Limited Cyclopropanecarboxylic acid derivative
HUE035072T2 (en) * 2010-03-18 2018-05-02 Daiichi Sankyo Co Ltd Cycloalkyl-substituted imidazole derivative
US9834527B2 (en) 2013-06-10 2017-12-05 Sanofi Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and their use as pharmaceuticals
CN108883094A (en) 2016-03-29 2018-11-23 第三共株式会社 Inflammatory bowel Remedies for diseases in association
BR112020005174A2 (en) 2017-09-14 2020-11-10 Daiichi Sankyo Company,Limited compound that has cyclic structure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901572D0 (en) * 1999-05-03 1999-05-03 Astra Ab New compounds
HUP0303763A3 (en) * 2000-08-17 2004-06-28 Pfizer Substituted imidazoles as tafia inhibitors, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PA8563501A1 (en) 2004-08-31
EP1467731A1 (en) 2004-10-20
MXPA04006573A (en) 2004-10-04
EA200400716A1 (en) 2004-12-30
BR0307016A (en) 2004-11-03
CA2472238A1 (en) 2003-07-31
WO2003061652A8 (en) 2004-09-10
NO20043457L (en) 2004-08-19
AP2004003084A0 (en) 2004-09-30
OA12756A (en) 2006-07-03
IS7310A (en) 2004-06-14
PL371487A1 (en) 2005-06-13
JP2005520811A (en) 2005-07-14
TNSN04121A1 (en) 2006-06-01
MA27167A1 (en) 2005-01-03
IL162677A0 (en) 2005-11-20
HRP20040659A2 (en) 2004-10-31
KR20040077775A (en) 2004-09-06
WO2003061652A1 (en) 2003-07-31
AR038197A1 (en) 2005-01-05
ECSP045200A (en) 2004-08-27
TW200302094A (en) 2003-08-01
CN1620291A (en) 2005-05-25
UY27615A1 (en) 2003-08-29

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed