PE20030853A1 - Metodos y composiciones para el tratamiento de patologias respiratorias - Google Patents
Metodos y composiciones para el tratamiento de patologias respiratoriasInfo
- Publication number
- PE20030853A1 PE20030853A1 PE2003000015A PE2003000015A PE20030853A1 PE 20030853 A1 PE20030853 A1 PE 20030853A1 PE 2003000015 A PE2003000015 A PE 2003000015A PE 2003000015 A PE2003000015 A PE 2003000015A PE 20030853 A1 PE20030853 A1 PE 20030853A1
- Authority
- PE
- Peru
- Prior art keywords
- respiratory
- myosin
- reduces
- light chain
- subjects
- Prior art date
Links
- 230000000241 respiratory effect Effects 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 102000003505 Myosin Human genes 0.000 abstract 2
- 108060008487 Myosin Proteins 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 239000002811 myosin light chain kinase inhibitor Substances 0.000 abstract 2
- 230000035699 permeability Effects 0.000 abstract 2
- 230000002685 pulmonary effect Effects 0.000 abstract 2
- -1 5-IODONAPHTHALEN-1-SULFONYL Chemical class 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 abstract 1
- 102000011131 Myosin-Light-Chain Phosphatase Human genes 0.000 abstract 1
- 108010037801 Myosin-Light-Chain Phosphatase Proteins 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 229940124748 beta 2 agonist Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 210000000981 epithelium Anatomy 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE AL USO DE COMPUESTOS i)QUE INHIBEN LA CONTRACCION DE LA CADENA LIGERA DE MIOSINA DE CELULAS EPITELIALES PULMONARES PARA PREPARAR UN MEDICAMENTO PARA EL TRATAMIENTO PREVENTIVO O CURATIVO DE PATOLOGIAS RESPIRATORIAS EXCLUYENDO HIPOXIA INDUCIDA POR DICHAS ENFERMEDADES RESPIRATORIAS; ii) INHIBEN LA FOSFORILACION DE LA CADENA LIGERA DE MIOSINA, INHIBIDOR DE QUINASA DE CADENA LIGERA DE MIOSINA (MLCK) TAL COMO {1-(5-YODONAFTALEN-1-SULFONIL)-1H-HEXAHIDRO-1,4-DIAZEPINA} (ML-7) ACTIVADOR DE LA MIOSINA FOSFATASA; iii)REDUCE LA PERMEABILIDAD PARACELULAR DEL EPITELIO PULMONAR, SIN PRESENTAR UN EFECTO SOBRE LA PERMEABILIDADD ENDOTELIAL VASCULAR; iv)REDUCE LA SENSIBILIDAD A LOS ALERGENOS EN SUJETOS QUE PRESENTAN O SON SENSIBLES A LAS ENFERMEDADES RESPIRATORIAS; v)REDUCE LA MIGRACION TRANSEPITELIAL DE CELULAS INMUNES Y LA ACUMULACION DE CELULAS INMUNES EN EL PULMON DE SUJETOS CON UNA PATOLOGIA RESPIRATORIA.TAMBIEN SE REFIERE AL USO EN COMBINACION CON BETA 2 AGONISTAS; ANTICOLINERGICOS; CORTICOSTEROIDES; ANTILEUCOTRIENOS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116706A FR2833839A1 (fr) | 2001-12-21 | 2001-12-21 | Methodes et compositions pour le traitement de pathologies respiratoires |
| FR0208606A FR2833840B1 (fr) | 2001-12-21 | 2002-07-09 | Methodes et compositions pour le traitement de pathologies respiratoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030853A1 true PE20030853A1 (es) | 2003-10-28 |
Family
ID=26213306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000015A PE20030853A1 (es) | 2001-12-21 | 2003-01-06 | Metodos y composiciones para el tratamiento de patologias respiratorias |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20050019314A1 (es) |
| EP (1) | EP1455767A2 (es) |
| AR (1) | AR038042A1 (es) |
| AU (1) | AU2002364679A1 (es) |
| CA (1) | CA2470442A1 (es) |
| FR (1) | FR2833840B1 (es) |
| PA (1) | PA8562701A1 (es) |
| PE (1) | PE20030853A1 (es) |
| SV (1) | SV2003001439A (es) |
| TW (1) | TW200305447A (es) |
| UY (1) | UY27589A1 (es) |
| WO (1) | WO2003053422A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| MY144231A (en) * | 2003-12-17 | 2011-08-15 | Wyeth Corp | Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME |
| CA2576971A1 (en) * | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| FR2879100B1 (fr) * | 2004-12-09 | 2007-07-06 | Lionel Bueno | Compositions pour le traitement des pathologies oculaires de surface et de la retine |
| US7893050B2 (en) * | 2005-10-26 | 2011-02-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| US20100144646A1 (en) * | 2006-11-03 | 2010-06-10 | Blake Paterson | Method of diagnosing and treating asthma |
| US20150038674A1 (en) * | 2013-08-05 | 2015-02-05 | Bayrak Bertan Boran | Use of glp-2 analogues in pulmonary diseases for therapeutic purpose |
| FR3145744A1 (fr) | 2023-02-11 | 2024-08-16 | Marc Grosman | Drone comportant au moins une pile à combustible, un calculateur dont un élément quantique ou supraconducteur, capable de réaliser plusieurs tâches au cours d’un vol sur zone difficile d’accès. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3748A (en) * | 1844-09-17 | Improvement in ratoon and cane cutters | ||
| US5030631A (en) * | 1989-11-27 | 1991-07-09 | Schering Corporation | Tricylclic arylsulfonamides |
| FR2674434B1 (fr) * | 1991-03-27 | 1993-06-18 | Nativelle Sa Ets | Nouvelle composition pharmaceutique a base de taurine pour l'administration par inhalation. |
| US5336503A (en) * | 1992-03-31 | 1994-08-09 | Daiichi Pharmaceutical Co., Ltd. | Anti-peptic ulcer agent |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| WO1994019336A1 (fr) * | 1993-02-19 | 1994-09-01 | Asahi Kasei Kogyo Kabushiki Kaisha | Derive de benzothiazolesulfonamide, procede de production et application de ce derive |
| AU703540B2 (en) * | 1996-03-26 | 1999-03-25 | Meddiss, Incorporated | Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general |
| SI0956865T2 (sl) * | 1996-08-12 | 2011-04-29 | Mitsubishi Pharma Corp | Zdravila, ki obsegajo inhibitor Rho-kinaze |
| AU9495798A (en) * | 1997-09-19 | 1999-04-05 | Ludwig Institute For Cancer Research | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| AU4990599A (en) * | 1998-07-14 | 2000-02-07 | Brigham And Women's Hospital | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
| MXPA03001468A (es) * | 2000-08-15 | 2004-05-04 | Immunex Corp | Polipeptidos de claudia. |
-
2002
- 2002-07-09 FR FR0208606A patent/FR2833840B1/fr not_active Expired - Fee Related
- 2002-12-18 UY UY27589A patent/UY27589A1/es not_active Application Discontinuation
- 2002-12-18 SV SV2002001439A patent/SV2003001439A/es not_active Application Discontinuation
- 2002-12-19 AR ARP020104998A patent/AR038042A1/es not_active Application Discontinuation
- 2002-12-20 PA PA20028562701A patent/PA8562701A1/es unknown
- 2002-12-20 CA CA002470442A patent/CA2470442A1/fr not_active Abandoned
- 2002-12-20 WO PCT/FR2002/004506 patent/WO2003053422A2/fr not_active Ceased
- 2002-12-20 US US10/498,094 patent/US20050019314A1/en not_active Abandoned
- 2002-12-20 TW TW091136815A patent/TW200305447A/zh unknown
- 2002-12-20 EP EP02805413A patent/EP1455767A2/fr not_active Withdrawn
- 2002-12-20 AU AU2002364679A patent/AU2002364679A1/en not_active Abandoned
- 2002-12-20 US US10/324,958 patent/US20030125321A1/en not_active Abandoned
-
2003
- 2003-01-06 PE PE2003000015A patent/PE20030853A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200305447A (en) | 2003-11-01 |
| AR038042A1 (es) | 2004-12-22 |
| US20030125321A1 (en) | 2003-07-03 |
| US20050019314A1 (en) | 2005-01-27 |
| AU2002364679A1 (en) | 2003-07-09 |
| UY27589A1 (es) | 2003-05-30 |
| EP1455767A2 (fr) | 2004-09-15 |
| SV2003001439A (es) | 2003-11-04 |
| CA2470442A1 (fr) | 2003-07-03 |
| PA8562701A1 (es) | 2004-02-16 |
| WO2003053422A2 (fr) | 2003-07-03 |
| FR2833840A1 (fr) | 2003-06-27 |
| FR2833840B1 (fr) | 2010-06-18 |
| AU2002364679A8 (en) | 2003-07-09 |
| WO2003053422A3 (fr) | 2004-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |