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PE20030824A1 - Formulacion superfina de formoterol - Google Patents

Formulacion superfina de formoterol

Info

Publication number
PE20030824A1
PE20030824A1 PE2003000199A PE2003000199A PE20030824A1 PE 20030824 A1 PE20030824 A1 PE 20030824A1 PE 2003000199 A PE2003000199 A PE 2003000199A PE 2003000199 A PE2003000199 A PE 2003000199A PE 20030824 A1 PE20030824 A1 PE 20030824A1
Authority
PE
Peru
Prior art keywords
solution
formoterol
formulation
administered
preparing
Prior art date
Application number
PE2003000199A
Other languages
English (en)
Inventor
David Ganderton
Alessandra Ferraris
Rebecca Jaine Davies
David Andrew Lewis
Brian John Meakin
Gaetano Brambilla
Tanya Kathleen Church
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27790093&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030824(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP02004786A external-priority patent/EP1340492A1/en
Priority claimed from EP02023589A external-priority patent/EP1415647A1/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20030824A1 publication Critical patent/PE20030824A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)

Abstract

QUE PUEDE SER ADMINISTRADA POR INHALACION DE UN AGONISTA BETA 2 DE ACCION PROLONGADA Y QUE COMPRENDE: 1)UN INGREDIENTE ACTIVO SELECCIONADO ENTRE: FORMOTEROL, UN ESTEREOISOMERO, UNA SAL O SOLVATO ACEPTABLE PARA EL USO FISIOLOGICO DEL MISMO, EN UNA SOLUCION DE PROPELENTE HFA LICUADO, TAL COMO: FUMARATO DE (R,R)-(+/-)-FORMOTEROL EN UNA CONCENTRACION COMPRENDIDA ENTRE 0,003 Y 0,192 % p/v; Y, 2)UN CO-SOLVENTE TAL COMO ETANOL EN FORMA ANHIDRA; DONDE, LA CANTIDAD DE AGUA RESIDUAL ES MENOR A 1500 ppm, SOBRE EL PESO TOTAL DE LA FORMULACION. DONDE, LA FRACCION DE PARTICULAS CON UN DIAMETRO IGUAL O MENOR A 1,1 um ADMINISTRADA AL ACCIONARSE EL INHALADOR ES MAYOR O IGUAL QUE 30%. SE REFIERE TAMBIEN A UN METODO PARA PREPARAR LA FORMULACION DESCRITA, QUE COMPRENDE: a)PREPARAR UNA SOLUCION DE UNO O MAS INGREDIENTES ACTIVOS EN (2); b)AJUSTAR OPCIONALMENTE EL pH DE LA SOLUCION; c)RELLENAR EL DISPOSITIVO CON LA SOLUCION; d)APLICAR VALVULAS Y GASIFICAR; Y, e)AGREGAR UN PROPELENTE QUE CONTIENE UN HIDROFLUOROALCANO (HFA)
PE2003000199A 2002-03-01 2003-02-28 Formulacion superfina de formoterol PE20030824A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004786A EP1340492A1 (en) 2002-03-01 2002-03-01 Aerosol formulations for pulmonary administration of medicaments having systemic effects
EP02023589A EP1415647A1 (en) 2002-10-23 2002-10-23 "Long-acting beta-2 agonists ultrafine formulations"

Publications (1)

Publication Number Publication Date
PE20030824A1 true PE20030824A1 (es) 2003-11-07

Family

ID=27790093

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2003000199A PE20030824A1 (es) 2002-03-01 2003-02-28 Formulacion superfina de formoterol
PE2003000202A PE20030827A1 (es) 2002-03-01 2003-02-28 Formulaciones hfa de agonistas beta-2 de derivados de 2(1h)-quinolinona de accion prolongada

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2003000202A PE20030827A1 (es) 2002-03-01 2003-02-28 Formulaciones hfa de agonistas beta-2 de derivados de 2(1h)-quinolinona de accion prolongada

Country Status (35)

Country Link
US (4) US20050152846A1 (es)
EP (6) EP1480615B1 (es)
JP (3) JP2005523905A (es)
KR (2) KR100947409B1 (es)
CN (2) CN100398094C (es)
AR (2) AR038641A1 (es)
AT (1) ATE465712T1 (es)
AU (2) AU2003222753B2 (es)
BR (2) BRPI0308274B8 (es)
CA (2) CA2477881C (es)
CO (2) CO5611091A2 (es)
CY (4) CY1111133T1 (es)
DE (1) DE60332321D1 (es)
DK (4) DK1480615T3 (es)
EA (2) EA007735B1 (es)
ES (4) ES2779273T3 (es)
GE (2) GEP20063986B (es)
HR (2) HRP20040752B1 (es)
HU (3) HUE049426T2 (es)
IL (3) IL163843A0 (es)
LT (3) LT3384931T (es)
MA (1) MA27175A1 (es)
ME (3) ME00077B (es)
MX (2) MXPA04008372A (es)
MY (2) MY137603A (es)
NO (2) NO342575B1 (es)
NZ (2) NZ535018A (es)
PE (2) PE20030824A1 (es)
PL (2) PL209212B1 (es)
PT (4) PT3494995T (es)
RS (2) RS52387B (es)
SI (4) SI3494995T1 (es)
TN (2) TNSN04149A1 (es)
TW (2) TW200303752A (es)
WO (2) WO2003074024A1 (es)

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