[go: up one dir, main page]

PE20030604A1 - Tetrahidroquinolinas - Google Patents

Tetrahidroquinolinas

Info

Publication number
PE20030604A1
PE20030604A1 PE2002000962A PE2002000962A PE20030604A1 PE 20030604 A1 PE20030604 A1 PE 20030604A1 PE 2002000962 A PE2002000962 A PE 2002000962A PE 2002000962 A PE2002000962 A PE 2002000962A PE 20030604 A1 PE20030604 A1 PE 20030604A1
Authority
PE
Peru
Prior art keywords
isopropyl
refers
tetrahydroquinolines
trifluoromethylphenil
fluorophenil
Prior art date
Application number
PE2002000962A
Other languages
English (en)
Inventor
Hilmar Bischoff
Christiane Faeste
Heiken Gielen
Siegfried Goldmann
Stephan Siegel
Holger Paulsen
Martin Raabe
Carsten Schmeck
Delf Schmidt
Jorg Keldenich
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20030604A1 publication Critical patent/PE20030604A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A TETRAHIDROQUINOLINAS DE FORMULA I DONDE A ES PARA-FLUOROFENILO, FENIL, TIOFENO ENTRE OTROS; B ES UN RADICAL PENTIL, PROPIL. SON COMPUESTOS PREFERIDOS 1-ISOPROPIL-3-(4-TRIFLUOROMETILFENIL)PROPAN-1,3-DIONA, 3-AMINO-3-ISOPROPIL-1-(4-TRIFLUOROMETILFENIL)PROPENONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA QUE INHIBE LAS PROTEINAS DE TRANSFERENCIA DE ESTER DE COLESTERINA (CETP) UTIL EN EL TRATAMIENTO DE DISLIPIDEMIA, HIPERTRIGLICERIDEMIA
PE2002000962A 2001-10-01 2002-09-30 Tetrahidroquinolinas PE20030604A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10148436A DE10148436A1 (de) 2001-10-01 2001-10-01 Tetrahydrochinoline

Publications (1)

Publication Number Publication Date
PE20030604A1 true PE20030604A1 (es) 2003-09-07

Family

ID=7701007

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000962A PE20030604A1 (es) 2001-10-01 2002-09-30 Tetrahidroquinolinas

Country Status (12)

Country Link
US (1) US20050043341A1 (es)
EP (1) EP1434581A1 (es)
JP (1) JP2005508341A (es)
AR (1) AR036583A1 (es)
CA (1) CA2462030A1 (es)
DE (1) DE10148436A1 (es)
DO (1) DOP2002000457A (es)
GT (1) GT200200195A (es)
HN (1) HN2002000278A (es)
PE (1) PE20030604A1 (es)
UY (1) UY27458A1 (es)
WO (1) WO2003028727A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101342162A (zh) * 2003-09-26 2009-01-14 日本烟草产业株式会社 抑制残余脂蛋白产生的方法
HRP20090581T1 (hr) 2003-10-08 2009-12-31 Eli Lilly And Company Spojevi i postupci za liječenje dislipidemije
ATE402180T1 (de) 2004-03-26 2008-08-15 Lilly Co Eli Verbindungen zur behandlung von dyslipidemie
ATE555097T1 (de) * 2004-12-18 2012-05-15 Bayer Pharma AG 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
AU2005324127A1 (en) * 2004-12-18 2006-07-13 Bayer Healthcare Ag (5S) -3-[(S)-fluoro (4-trifluoromethylphenyl) methyl]-5,6,7,8-tetrahydroquinoline-5-ol derivatives and use thereof as CETP inhibitors
DE102006012548A1 (de) 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US20080145498A1 (en) * 2006-12-14 2008-06-19 Kraft Foods Holdings, Inc. Texture and shape control process for acidified food products
CN102015722A (zh) 2008-03-05 2011-04-13 贝林格尔.英格海姆国际有限公司 三环吡啶衍生物、包含此类化合物的药物、它们的用途及其制备方法
PH12012501661A1 (en) 2010-02-19 2012-10-22 Boehringer Ingelheim Int Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
WO2012005343A1 (ja) 2010-07-09 2012-01-12 第一三共株式会社 置換ピリジン化合物
WO2013024130A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
US9321747B2 (en) 2012-01-06 2016-04-26 Daiichi Sankyo Company, Limited Acid addition salt of substituted pyridine compound
WO2016037534A1 (en) * 2014-09-09 2016-03-17 Boehringer Ingelheim International Trading (Shanghai) Co. Ltd. Novel process for preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970330B1 (en) * 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
MA24643A1 (fr) * 1997-09-18 1999-04-01 Bayer Ag Tetrahydro-naphtalenes substitues et composes analogues
DE19741399A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Tetrahydrochinoline

Also Published As

Publication number Publication date
AR036583A1 (es) 2004-09-15
DOP2002000457A (es) 2003-04-15
WO2003028727A9 (de) 2003-11-13
UY27458A1 (es) 2003-04-30
GT200200195A (es) 2003-08-22
DE10148436A1 (de) 2003-04-17
WO2003028727A1 (de) 2003-04-10
CA2462030A1 (en) 2003-04-10
EP1434581A1 (de) 2004-07-07
HN2002000278A (es) 2002-12-20
JP2005508341A (ja) 2005-03-31
US20050043341A1 (en) 2005-02-24

Similar Documents

Publication Publication Date Title
PE20030604A1 (es) Tetrahidroquinolinas
BR0108395A (pt) Derivados de pirrolopirimidinona, processos de preparação e uso
DK0863891T3 (da) (Methylsulfonyl)phenyl-2-(5H)-furanoner som COX2-inhibitorer
BG66084B1 (bg) Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
BR0012450A (pt) Benzimidazóis substituìdos
CR7743A (es) Nuevos compuestos de oxazol y tiazol como inhibidorea del factor de crecimiento transformador (tgf)
ES2115237T3 (es) Fenil heterociclos como inhibidores de la ciclooxigenasa-2.
DK1206474T3 (da) Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
BG66080B1 (bg) Заместени тиоацетамиди
AR021843A1 (es) Derivados de propanolamina sustituidos con heterociclos, procedimiento para su preparacion, y su utilizacion.
PT1251846E (pt) Taxanos com carbonato c-4
HRP20050103A2 (en) N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion
PA8525801A1 (es) Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2
ES2182035T3 (es) Derivados del bisarilciclobuteno como inhibidores de ciclooxigenasa.
DE69702182D1 (de) Alkylierte styrole als prodrugs zu cox-2-inhibitoren
ATE335739T1 (de) Cak inhibitoren und deren verwendungen
BR0309009A (pt) Método para o tratamento de hipersecreção de muco
ATE301933T1 (de) Akarizidpulver
NO20010140D0 (no) Kjemotakse-inhiberende protein av Staphylo-Coccus (CHIPS) og dets anvendelse
DE69828522D1 (de) Antithrombotische mittel
ATE294790T1 (de) Chlormethylierung von thiophene
DE59809344D1 (de) Disubstituierte biphenyloxazoline
EP1802297A4 (en) COMPOSITIONS AND METHODS OF TREATING DISEASES INDIRECTED BY INFECTION WITH YERSINIA SPP
GT200000114A (es) Forma cristalina iii de la n-(4-(5-dimetilaminoftalen-1-sulfonilamino) fenil)-3-hidroxi-2, 2-dimetilpropionamida.
BR0317445A (pt) Composto, composição farmacêutica, método para o tratamento de doenças, e, uso de um composto

Legal Events

Date Code Title Description
FD Application declared void or lapsed