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PE20030413A1 - Acido homoiminopiperidinilo hexanoico como inhibidores de oxido nitrico sintasa - Google Patents

Acido homoiminopiperidinilo hexanoico como inhibidores de oxido nitrico sintasa

Info

Publication number
PE20030413A1
PE20030413A1 PE2001000771A PE2001000771A PE20030413A1 PE 20030413 A1 PE20030413 A1 PE 20030413A1 PE 2001000771 A PE2001000771 A PE 2001000771A PE 2001000771 A PE2001000771 A PE 2001000771A PE 20030413 A1 PE20030413 A1 PE 20030413A1
Authority
PE
Peru
Prior art keywords
homoiminopiperidinyl
inhibitors
nitric oxide
oxide synthase
hexanoic acid
Prior art date
Application number
PE2001000771A
Other languages
English (en)
Inventor
Alok K Awasthi
Thaddeus S Franczyk
Donald W Hansen
Ronald Keith Webber
Jeffrey S Snyder
Mahima Trivedi
Alan E Moormann
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PE20030413A1 publication Critical patent/PE20030413A1/es

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    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DEL ACIDO HOMOIMINOPIPERIDINIL HEXANOICO DE FORMULA I. SON COMPUESTOS PREFERIDOS ACIDO (OS,2R)-O-AMINOHEXAHIDRO-7-IMINO-1H-AZEPINA-2-HEXANOICO; ACIDO (2S,4Z)-2-AMINO-6-[(5R)-6,7,8,9-TETRAHIDRO-3-OXO-3H,5H-[1,2,4]-OXADIAZOLO[4,3-O]AZEPIN-5-IL]-4-HEXENOICO; LOS CUALES SON INHIBIDORES DE SINTASA DEL OXIDO NITRICO INDUCIBLE UTILES PARA EL TRATAMIENTO DE INFLAMACION, ANALGESICO, DOLOR, CEFALEAS, GLAUCOMA, RETINITIS, RETINOPATIAS, UVEITIS, FOTOFOBIA OCULAR
PE2001000771A 2000-08-01 2001-10-09 Acido homoiminopiperidinilo hexanoico como inhibidores de oxido nitrico sintasa PE20030413A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22217900P 2000-08-01 2000-08-01

Publications (1)

Publication Number Publication Date
PE20030413A1 true PE20030413A1 (es) 2003-05-20

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PE2001000771A PE20030413A1 (es) 2000-08-01 2001-10-09 Acido homoiminopiperidinilo hexanoico como inhibidores de oxido nitrico sintasa

Country Status (11)

Country Link
US (1) US6495544B2 (es)
EP (1) EP1305293A1 (es)
JP (1) JP2004512271A (es)
AR (1) AR032360A1 (es)
AU (1) AU2001281083A1 (es)
CA (1) CA2415851A1 (es)
EA (1) EA005817B1 (es)
MX (1) MXPA03000772A (es)
NZ (1) NZ523770A (es)
PE (1) PE20030413A1 (es)
WO (1) WO2002010139A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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