PE20021153A1 - 5- [2-BUTOXY-5- (1-HYDROXYETHYL) -3-PYRIDINYL] -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PYRAZOLE [4,3- d] PYRIMIDIN-7-ONA AS INHIBITORS OF GUANOSIN 3 ', 5'-CYCLIC MONOPHOSPHATE PHOSPHODIESTERASES - Google Patents
5- [2-BUTOXY-5- (1-HYDROXYETHYL) -3-PYRIDINYL] -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PYRAZOLE [4,3- d] PYRIMIDIN-7-ONA AS INHIBITORS OF GUANOSIN 3 ', 5'-CYCLIC MONOPHOSPHATE PHOSPHODIESTERASESInfo
- Publication number
- PE20021153A1 PE20021153A1 PE2002000183A PE2002000183A PE20021153A1 PE 20021153 A1 PE20021153 A1 PE 20021153A1 PE 2002000183 A PE2002000183 A PE 2002000183A PE 2002000183 A PE2002000183 A PE 2002000183A PE 20021153 A1 PE20021153 A1 PE 20021153A1
- Authority
- PE
- Peru
- Prior art keywords
- ethyl
- azethydinyl
- ona
- pyrimidin
- pyridinyl
- Prior art date
Links
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 title abstract 3
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000004712 monophosphates Chemical class 0.000 title abstract 2
- 230000001568 sexual effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004064 dysfunction Effects 0.000 abstract 2
- -1 5-ACETYL-2 -BUTOXY-3-PYRIDINYL Chemical class 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A 5-[2-BUTOXI-5-(1-HIDROXIETIL)-3-PIRIDINIL]-3-ETIL-2-(1-ETIL-3-AZETIDINIL)-2,6-DIHIDRO-7H-PIRAZOLO[4,3-d]PIRIMIDIN-7-ONA DE FORMULA I DONDE R1 ES H, CO-ALQUILO C1-C4, CO-ARILO, CO-HETEROARILO CON LA CONDICION QUE NO SE OBTENGA POR METABOLISMO DE 5-(5-ACETIL-2-BUTOXI-3-PIRIDINIL)-3-ETIL-2-(1-ETIL-3-AZETIDINIL)-2,6-DIHIDRO-7H-PIRAZOLO[4,3-d]PIRIMIDIN-7-ONA EN EL CUERPO; SON COMPUESTOS PREFERIDOS 5-[2-BUTOXI-5-(1-HIDROXIETIL)-3-PIRIDINIL]-3-ETIL-2-(1-ETIL-3-AZETIDINIL)-2,6-DIHIDRO-7H-PIRAZOLO[4,3-d]PIRIMIDIN-7-ONA; LOS COMPUESTOS SON INHIBIDORES DE FOSFODIESTERASAS DE GUANOSIN 3',5'-MONOFOSFATO CICLICO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DISFUNCION ERECTIL MASCULINA, IMPOTENCIA, DISFUNCION SEXUAL FEMENINA, DISFUNCION DEL CLITORIS, TRASTORNO DE DESEO SEXUAL HIPOACTIVO FEMENINO, TRASTORNO DE EXCITACION SEXUAL FEMENINO, TRASTORNO DE DOLOR SEXUAL FEMENINO O DISFUNCION ORGASMICA SEXUAL FEMENINAREFERS TO 5- [2-BUTOXY-5- (1-HYDROXYETHYL) -3-PYRIDINYL] -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PIRAZOLO [4 , 3-d] PYRIMIDIN-7-ONA OF FORMULA I WHERE R1 IS H, CO-ALKYL C1-C4, CO-ARYL, CO-HETEROARYL WITH THE CONDITION THAT IT IS NOT OBTAINED BY METABOLISM OF 5- (5-ACETYL-2 -BUTOXY-3-PYRIDINYL) -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PYRAZOLE [4,3-d] PYRIMIDIN-7-ONA IN THE BODY; PREFERRED COMPOUNDS ARE 5- [2-BUTOXY-5- (1-HYDROXYETHYL) -3-PYRIDINYL] -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PYRAZOLE [4 , 3-d] PYRIMIDIN-7-ONA; THE COMPOUNDS ARE INHIBITORS OF GUANOSIN 3 ', 5'-CYCLIC MONOPHOSPHATE PHOSPHODIESTERASES AND MAY BE USEFUL FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION, IMPOTENCY, FEMALE SEXUAL DYSFUNCTION, CLITINO DYSFUNCTION, SEXIMO DISFUNCTION, SEXEMACTIVE DISFUNCTION, SEXUAL DISFUNCTION, SEXEMACTIVE DISFUNCTION. , FEMALE SEXUAL PAIN DISORDER OR FEMALE SEXUAL ORGASMIC DYSFUNCTION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0105893.2A GB0105893D0 (en) | 2001-03-09 | 2001-03-09 | Pharmaceutically active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021153A1 true PE20021153A1 (en) | 2002-12-17 |
Family
ID=9910362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000183A PE20021153A1 (en) | 2001-03-09 | 2002-03-07 | 5- [2-BUTOXY-5- (1-HYDROXYETHYL) -3-PYRIDINYL] -3-ETHYL-2- (1-ETHYL-3-AZETHYDINYL) -2,6-DIHYDRO-7H-PYRAZOLE [4,3- d] PYRIMIDIN-7-ONA AS INHIBITORS OF GUANOSIN 3 ', 5'-CYCLIC MONOPHOSPHATE PHOSPHODIESTERASES |
Country Status (8)
| Country | Link |
|---|---|
| AP (1) | AP2002002462A0 (en) |
| GB (1) | GB0105893D0 (en) |
| GT (1) | GT200200044A (en) |
| HN (1) | HN2002000050A (en) |
| PA (1) | PA8541101A1 (en) |
| PE (1) | PE20021153A1 (en) |
| TN (1) | TNSN02023A1 (en) |
| WO (1) | WO2002072586A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| EP2196201A3 (en) | 2002-12-13 | 2010-12-08 | Warner-Lambert Company LLC | Combination of an alpha-2-delta ligand with a pdev inhibitor or a muscarinic antagonist to treat lower urinary tract symptoms |
| BRPI0411985A (en) * | 2003-07-16 | 2006-08-29 | Pfizer | treatment of sexual dysfunction |
| ES2646326T3 (en) | 2005-08-03 | 2017-12-13 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
| CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| ATE456369T1 (en) | 2006-06-30 | 2010-02-15 | Boehringer Ingelheim Int | FLIBANSERIN FOR THE TREATMENT OF URINARY INCONTINENCE AND ASSOCIATED DISEASES |
| AU2007286288A1 (en) | 2006-08-14 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
| BRPI0716436B8 (en) | 2006-08-25 | 2021-05-25 | Boehringer Ingelheim Int | controlled release system and method for manufacturing it |
| CL2008002693A1 (en) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Use of flibanserin for the treatment of selected vasomotor symptoms of hot flashes, night sweats, mood swings, and irritability |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL343794A1 (en) * | 1998-04-20 | 2001-09-10 | Pfizer | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction |
| GB9823101D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| AU7547900A (en) * | 1999-10-11 | 2001-04-23 | Pfizer Inc. | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo(4,3-d)pyrimidin-7-ones as phosphodiesterase inhibitors |
| CO5271697A1 (en) * | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | COMPOSITIONS AND PROCEDURES FOR THE TREATMENT OF AFFECTIONS THAT RESPOND TO AN INCREASE OF TESTOSTERONE |
-
2001
- 2001-03-09 GB GBGB0105893.2A patent/GB0105893D0/en not_active Ceased
-
2002
- 2002-02-27 WO PCT/IB2002/000622 patent/WO2002072586A1/en not_active Ceased
- 2002-03-06 GT GT200200044A patent/GT200200044A/en unknown
- 2002-03-07 AP APAP/P/2002/002462A patent/AP2002002462A0/en unknown
- 2002-03-07 PE PE2002000183A patent/PE20021153A1/en not_active Application Discontinuation
- 2002-03-08 PA PA20028541101A patent/PA8541101A1/en unknown
- 2002-03-08 TN TNTNSN02023A patent/TNSN02023A1/en unknown
- 2002-03-08 HN HN2002000050A patent/HN2002000050A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0105893D0 (en) | 2001-04-25 |
| GT200200044A (en) | 2002-12-02 |
| HN2002000050A (en) | 2002-09-13 |
| PA8541101A1 (en) | 2003-11-12 |
| WO2002072586A1 (en) | 2002-09-19 |
| AP2002002462A0 (en) | 2002-06-30 |
| TNSN02023A1 (en) | 2005-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |