PE20021044A1 - DIPHENYL DERIVATIVES - Google Patents
DIPHENYL DERIVATIVESInfo
- Publication number
- PE20021044A1 PE20021044A1 PE2002000187A PE2002000187A PE20021044A1 PE 20021044 A1 PE20021044 A1 PE 20021044A1 PE 2002000187 A PE2002000187 A PE 2002000187A PE 2002000187 A PE2002000187 A PE 2002000187A PE 20021044 A1 PE20021044 A1 PE 20021044A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycle
- chf
- alkenyl
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A DERIVADOS DE DIFENILO DE FORMULA I DONDE X ES O, S, SO, SO2, CH2, CHF, CF2, NR8; R8 ES H, ALQUILO C1-C4; R1 Y R2 SON H, ALQUILO C1-C4; R3 Y R4 SON H, HALOGENO, CIANO, ALQUILO C1-C6, CF3, CHF2, CH2F, VINILO, CICLOALQUILO C3-C7; R5 ES H, ALQUILO C1-C4, HALOGENO, R6 ES SR9, SOnR10, NR11COR12, CH2R13, M-R14; R9 ES ALQUILO C1-C10, CICLOALQUILO C3-C8, ALQUENILO C2-C6, ARILO C6-C10, ARILMETILO C6-C10, HETEROCICLO; n ES 1-2; R10 Y R14 SON OR15, NR16R17, ALQUILO C1-C10, CICLOALQUILO C3-C8, ALQUENILO C2-C6, ENTRE OTROS; R15, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28 SON H, FENILO, BENCILO, ALQUILO C1-C6, CICLOALQUILO C3-C8; R16 Y R17 SON H, ALQUILO C1-C6; R11 ES H, ALQUILO C1-C6, R12 ES ALQUILO C1-C15, HETEROCICLO, DE 5-6 MIEMBROS, OR29, NR30R31; R29 ES ALQUILO C1-C6, R30 Y R31 SON H, ALQUILO C1-C12, HETEROCICLO DE 5-7 MIEMBROS; R13 ES HETEROCICLO DE 5-10 MIEMBROS, NR34R35; R34 Y R35 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8; M ES CO, CHOH, CHF, CF2; R7 ES H, ALQUILO C1-C4, ALCANOILO C1-C4; Z ES -Aa-D-CO-R36; A ES O, S; a ES 0-1; D ES ALQUILENO C1-C4 OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C3, OH, F; R36 ES OR37, NR38R39; R37, R38, R39 SON H, FENILO, BENCILO, ALQUILO C1-C6, CICLOALQUILO C3-C8. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE ARTERIOESCLEROSIS, ADIPOSIDAD, OBESIDAD, HIPERCOLESTEROLEMIA, DISLIPIDEMIA, INSUFICIENCIA CARDIACAREFERS TO DIPHENYL DERIVATIVES OF FORMULA I WHERE X IS O, S, SO, SO2, CH2, CHF, CF2, NR8; R8 IS H, C1-C4 ALKYL; R1 AND R2 ARE H, C1-C4 ALKYL; R3 AND R4 ARE H, HALOGEN, CYANE, C1-C6 ALKYL, CF3, CHF2, CH2F, VINYL, C3-C7 CYCLOALKYL; R5 IS H, C1-C4 ALKYL, HALOGEN, R6 IS SR9, SOnR10, NR11COR12, CH2R13, M-R14; R9 IS C1-C10 ALKYL, C3-C8 CYCLOALKYL, C2-C6 ALKENYL, C6-C10 ARYL, C6-C10 ARYLMETYL, HETEROCYCLE; n IS 1-2; R10 AND R14 ARE OR15, NR16R17, C1-C10 ALKYL, C3-C8 CYCLOALKYL, C2-C6 ALKENYL, AMONG OTHERS; R15, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28 ARE H, PHENYL, BENZYL, C1-C6 ALKYL, C3-C8 CYCLOALKYL; R16 AND R17 ARE H, C1-C6 ALKYL; R11 IS H, C1-C6 ALKYL, R12 IS C1-C15 ALKYL, HETEROCYCLE, 5-6 MEMBERS, OR29, NR30R31; R29 IS C1-C6 ALKYL, R30 AND R31 ARE H, C1-C12 ALKYL, 5-7 MEMBER HETEROCYCLE; R13 IS 5-10 MEMBER HETEROCYCLE, NR34R35; R34 AND R35 ARE H, C1-C8 ALKYL, C3-C8 CYCLOALKYL; M IS CO, CHOH, CHF, CF2; R7 IS H, C1-C4 ALKYL, C1-C4 ALKANOYL; Z ES -Aa-D-CO-R36; A IS O, S; a ES 0-1; D IS C1-C4 ALKYLENE OPTIONALLY SUBSTITUTED WITH C1-C3 ALKYL, OH, F; R36 IS OR37, NR38R39; R37, R38, R39 ARE H, PHENYL, BENZYL, C1-C6 ALKYL, C3-C8 CYCLOALKYL. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE COMPOUNDS MAY BE USEFUL FOR THE TREATMENT OF ARTERIOSCLEROSIS, ADIPOSITY, OBESITY, HYPERCHOLESTEROLEMIA, DYSLIPIDEMIA, HEART FAILURE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10111651 | 2001-03-12 | ||
| DE10130835A DE10130835A1 (en) | 2001-03-12 | 2001-06-27 | Diphenyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021044A1 true PE20021044A1 (en) | 2002-12-12 |
Family
ID=7677048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000187A PE20021044A1 (en) | 2001-03-12 | 2002-03-11 | DIPHENYL DERIVATIVES |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE10130835A1 (en) |
| GT (1) | GT200200047A (en) |
| HN (1) | HN2002000052A (en) |
| PE (1) | PE20021044A1 (en) |
-
2001
- 2001-06-27 DE DE10130835A patent/DE10130835A1/en not_active Withdrawn
-
2002
- 2002-03-11 GT GT200200047A patent/GT200200047A/en unknown
- 2002-03-11 HN HN2002000052A patent/HN2002000052A/en unknown
- 2002-03-11 PE PE2002000187A patent/PE20021044A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HN2002000052A (en) | 2003-06-06 |
| GT200200047A (en) | 2003-02-13 |
| DE10130835A1 (en) | 2002-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |