PE20020342A1 - QUINUCLIDINE GROUPS SUBSTITUTED WITH HETEROARYL FOR THE TREATMENT OF DISEASES - Google Patents
QUINUCLIDINE GROUPS SUBSTITUTED WITH HETEROARYL FOR THE TREATMENT OF DISEASESInfo
- Publication number
- PE20020342A1 PE20020342A1 PE2001000831A PE2001000831A PE20020342A1 PE 20020342 A1 PE20020342 A1 PE 20020342A1 PE 2001000831 A PE2001000831 A PE 2001000831A PE 2001000831 A PE2001000831 A PE 2001000831A PE 20020342 A1 PE20020342 A1 PE 20020342A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- heteroaryl
- treatment
- quinuclidine
- cycloalkyl
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE QUINUCLIDINA SUSTITUIDOS CON HETEROARILO DE FORMULA I; DONDE R1 ES H, ALQUILO, CICLOALQUILO, ALQUILO HALOGENADO, ARILO; R2 ES H, ALQUILO, HALOALQUILO, CICLOALQUILO, BENCILO, ARILO; X ES O, S; W ES GRUPO a, b; U ES O, S, NR3; V E Y SON =N, =C(R5); Z ES =N, =CH; CUANDO V E Y SON =CR5, Z ES =CH, SOLO UNO DE =CR5 ES =CH; CUANDO U ES O, Y ES =CR5, Z ES =CR5, V NO ES =N; R3 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; CUANDO W ES EL GRUPO b; Z ES =N; U ES NR3; R3 NO ES FENILO; R5 ES H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-5-FENIL-TIOFEN-2-CARBOXAMIDA, N-[(2S,3R)-2-METIL-1-AZABICICLO[2.2.2]OCT-3-IL]-5-FENIL-TIOFEN-2-CARBOXAMIDA; ENTRE OTROS; UTILIZANDOSE DE 0,001mg/Kg A 100mg/Kg. LOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE ACETILCOLINA O7 NICOTINICO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS DE DEFICIT DE ATENCION, TRASTORNOS DEL HUMOR Y AFECTIVOSREFERS TO QUINUCLIDINE COMPOUNDS SUBSTITUTED WITH HETEROARYL OF FORMULA I; WHERE R1 IS H, ALKYL, CYCLOALKYL, HALOGENED ALKYL, ARYL; R2 IS H, ALKYL, HALOALKYL, CYCLOALKYL, BENZYL, ARYL; X IS O, S; W IS GROUP a, b; U IS O, S, NR3; V E Y SON = N, = C (R5); Z ES = N, = CH; WHEN V E Y ARE = CR5, Z IS = CH, ONLY ONE OF = CR5 IS = CH; WHEN U IS O, AND IS = CR5, Z IS = CR5, V IS NOT = N; R3 IS H, ALKYL, CYCLOALKYL, AMONG OTHERS; WHEN W IS GROUP b; Z ES = N; U IS NR3; R3 IS NOT PHENYL; R5 IS H, ALKYL, ALKENYL, ALKINYL, AMONG OTHERS; PREFERRED COMPOUNDS ARE N - [(3R) -1-AZABICYCLO [2.2.2] OCT-3-IL] -5-PHENYL-THIOFEN-2-CARBOXAMIDE, N - [(2S, 3R) -2-METHYL-1- AZABICYCLO [2.2.2] OCT-3-IL] -5-PHENYL-THIOFEN-2-CARBOXAMIDE; AMONG OTHERS; USING FROM 0.001mg / Kg TO 100mg / Kg. THE COMPOUNDS ARE INHIBITORS OF THE ACETYLCHOLINE O7 NICOTINIUM RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF ATTENTION-DEFICIT DISORDERS, HUMOR DISORDERS AND AFFECTIVES
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22665200P | 2000-08-21 | 2000-08-21 | |
| US28484901P | 2001-04-19 | 2001-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020342A1 true PE20020342A1 (en) | 2002-04-18 |
Family
ID=44359200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000831A PE20020342A1 (en) | 2000-08-21 | 2001-08-21 | QUINUCLIDINE GROUPS SUBSTITUTED WITH HETEROARYL FOR THE TREATMENT OF DISEASES |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE20020342A1 (en) |
-
2001
- 2001-08-21 PE PE2001000831A patent/PE20020342A1/en not_active Application Discontinuation
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