PE20020994A1 - Composicion antifungal con aumentada biodisponibilidad - Google Patents
Composicion antifungal con aumentada biodisponibilidadInfo
- Publication number
- PE20020994A1 PE20020994A1 PE2002000263A PE2002000263A PE20020994A1 PE 20020994 A1 PE20020994 A1 PE 20020994A1 PE 2002000263 A PE2002000263 A PE 2002000263A PE 2002000263 A PE2002000263 A PE 2002000263A PE 20020994 A1 PE20020994 A1 PE 20020994A1
- Authority
- PE
- Peru
- Prior art keywords
- acid
- liquid
- biodavailability
- triazol
- refers
- Prior art date
Links
- 239000012871 anti-fungal composition Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 239000007788 liquid Substances 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- -1 GLYCERYL ESTERS Chemical class 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229920002675 Polyoxyl Polymers 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 229920001400 block copolymer Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000006194 liquid suspension Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 abstract 1
- 229960001589 posaconazole Drugs 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION LIQUIDA ESTABLE QUE COMPRENDE a)POSACONAZOL O (2R-CIS)-4-[4-[4-[4-[[5-2,4-DIFLUOROFENIL)-TETRAHIDRO-5-(H-i,2,4-TRIAZOL-1-ILMETIL)FURAN-3-IL]METOXIFENIL-1-PIPERAZINIL]FENIL]2,4-DIHIDRO-2-[(S)-1-ETIL-2(S)HIDROXIPROPIL]-3H-1,2,4-TRIAZOL-3-ONA MICRONIZADO DE FORMULA I CON UN TAMANO DE PARTICULA DE 1200nm A 1600nm; b)AGENTE ESPESADOR COMO GOMA DE XANTANO, AZUCAR LIQUIDO, ALMIDON, CELULOSA; c)SURFACTANTE NO IONICO COMO UN COPOLIMERO DE BLOQUE DE OXIDO DE ETILENO, OXIDO DE PROPILENGLICOL, GLICERIL ESTERES DE ACIDOS C8-C20, ESTERES DE POLIOXIETILENO DE ACIDO C8-C20, ETERES DE POLIOXIETILENO C8-C20, POLIVINIL ALCOHOL, ESTERES DE SORBITAN DE ACIDO C10-C20; d)PORTADOR LIQUIDO COMO AGUA PURIFICADA, GLUCOSA, GLICERINA. TAMBIEN SE REFIERE A UNA SUSPENSION LIQUIDA QUE COMPRENDE UN COMPUESTO I, UN AGENTE ESPESADOR, BUFFER QUE MANTIENE EL pH DE 4 A 6, TAL COMO ACIDO CITRICO Y CITRATO DE SODIO, UN SURFACTANTE NO IONICO, PORTADOR LIQUIDO. LA COMPOSICION TIENE MEJOR BIODISPONIBILIDAD Y MEJOR ACTIVIDAD ANTIFUNGAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28113901P | 2001-04-03 | 2001-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020994A1 true PE20020994A1 (es) | 2002-11-01 |
Family
ID=23076102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000263A PE20020994A1 (es) | 2001-04-03 | 2002-04-02 | Composicion antifungal con aumentada biodisponibilidad |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20030055067A1 (es) |
| EP (2) | EP2090165A3 (es) |
| JP (2) | JP4308902B2 (es) |
| KR (1) | KR100607742B1 (es) |
| CN (1) | CN100415234C (es) |
| AR (1) | AR033096A1 (es) |
| AU (1) | AU2002257104B2 (es) |
| BR (1) | BR0208626A (es) |
| CA (1) | CA2443089C (es) |
| HU (1) | HUP0400856A3 (es) |
| MX (1) | MXPA03009021A (es) |
| NO (1) | NO20034419L (es) |
| NZ (1) | NZ528363A (es) |
| PE (1) | PE20020994A1 (es) |
| PL (1) | PL212985B1 (es) |
| TW (1) | TWI311464B (es) |
| WO (1) | WO2002080678A1 (es) |
| ZA (1) | ZA200307684B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
| EP1761247A1 (en) * | 2004-05-28 | 2007-03-14 | Schering Corporation | Injectable pharmaceutical suspension comprising posaconazole |
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| US7473684B2 (en) * | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
| SG170047A1 (en) | 2006-05-30 | 2011-04-29 | Elan Pharma Int Ltd | Nanoparticulate posaconazole formulations |
| AR061351A1 (es) | 2006-06-14 | 2008-08-20 | Intervet Int Bv | Composicion de carbamato de bencimidazol |
| GB0624084D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
| GB0624090D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amine salts |
| GB0624087D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril combination salt |
| FR2910323A1 (fr) * | 2006-12-26 | 2008-06-27 | Virbac Sa Sa | Composition liquide anhydre destinee a etre incorporee a l'eau de boisson des animaux d'elevage. |
| DE102008004893A1 (de) | 2008-01-17 | 2009-07-23 | Add Technologies Ltd. | Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung |
| JP2011516613A (ja) * | 2008-04-15 | 2011-05-26 | シェーリング コーポレイション | 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 |
| CN102065842A (zh) * | 2008-04-15 | 2011-05-18 | 先灵公司 | 优选含有泊沙康唑和hpmcas的固体分散体形式的口服药物组合物 |
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| US20120101277A1 (en) | 2009-07-09 | 2012-04-26 | Sandoz Ag | Crystalline form of posaconazole |
| EP2571869B1 (en) | 2010-05-19 | 2015-09-23 | Sandoz AG | Purification of posaconazole and posaconazole intermediates |
| EP2571871B1 (en) | 2010-05-19 | 2017-06-21 | Sandoz AG | Process for the preparation of chiral triazolones |
| CN102892762B (zh) | 2010-05-19 | 2016-04-20 | 桑多斯股份公司 | 制备泊沙康唑中间体 |
| CN102892750B (zh) | 2010-05-19 | 2016-03-02 | 桑多斯股份公司 | 制备手性酰肼的方法 |
| WO2012172015A1 (en) | 2011-06-16 | 2012-12-20 | Sandoz Ag | Process for the preparation of a chiral compound |
| CN104379132A (zh) | 2012-06-14 | 2015-02-25 | 桑多斯股份公司 | 包含结晶泊沙康唑的药物组合物 |
| EA033736B1 (ru) | 2014-12-05 | 2019-11-20 | Pulmocide Ltd | Антимикотическое соединение |
| CN107635988B (zh) * | 2015-05-21 | 2021-06-18 | 普尔莫赛德有限公司 | 抗真菌的苯甲酰胺类衍生物或其可药用盐 |
| CN105030668B (zh) * | 2015-06-26 | 2018-03-27 | 济川药业集团有限公司 | 泊沙康唑口服混悬剂及其制备方法 |
| CN106333925B (zh) * | 2015-07-10 | 2019-06-18 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑液体混悬剂及其制备方法 |
| EA038421B1 (ru) * | 2015-12-30 | 2021-08-26 | ВиПиЭс-3, ИНК. | Соединения, ингибирующие металлоферменты |
| CN106389390A (zh) * | 2016-06-30 | 2017-02-15 | 重庆华邦制药有限公司 | 泊沙康唑涂膜剂及其制备方法 |
| CN107625729A (zh) * | 2017-09-29 | 2018-01-26 | 重庆华邦制药有限公司 | 泊沙康唑口服混悬液及其制备方法 |
| CN110507609B (zh) * | 2018-05-21 | 2021-09-17 | 上海医药工业研究院 | 泊沙康唑口服混悬剂的制备方法 |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| WO2021229359A2 (en) * | 2020-05-12 | 2021-11-18 | Cellix Bio Private Limited | Process for the preparation salts of triazole compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| US4788220A (en) * | 1987-07-08 | 1988-11-29 | American Home Products Corporation (Del.) | Pediatric ibuprofen compositions |
| NZ234143A (en) * | 1989-06-28 | 1991-10-25 | Mcneil Ppc Inc | Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5552160A (en) | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| AU642066B2 (en) | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| US5661151A (en) | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| JP2834889B2 (ja) | 1993-12-21 | 1998-12-14 | シェーリング コーポレイション | テトラヒドロフラン抗真菌剤 |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5580579A (en) * | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| EP0862917A4 (en) * | 1995-11-20 | 2002-01-09 | Banyu Pharma Co Ltd | ANTIFUNGAL COMPOSITION |
| US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| WO1998051281A1 (en) * | 1997-05-14 | 1998-11-19 | Senju Pharmaceutical Co., Ltd. | Aqueous suspension preparations with excellent redispersibility |
| WO1999061001A1 (en) | 1998-05-29 | 1999-12-02 | Rtp Pharma Inc. | Thermoprotected microparticle compositions and process for terminal steam sterilization thereof |
| US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
-
2002
- 2002-04-01 CN CNB028077407A patent/CN100415234C/zh not_active Expired - Lifetime
- 2002-04-01 EP EP09158184A patent/EP2090165A3/en not_active Withdrawn
- 2002-04-01 WO PCT/US2002/010093 patent/WO2002080678A1/en not_active Ceased
- 2002-04-01 CA CA2443089A patent/CA2443089C/en not_active Expired - Lifetime
- 2002-04-01 NZ NZ528363A patent/NZ528363A/en not_active IP Right Cessation
- 2002-04-01 BR BR0208626-3A patent/BR0208626A/pt not_active Application Discontinuation
- 2002-04-01 PL PL363965A patent/PL212985B1/pl unknown
- 2002-04-01 US US10/114,612 patent/US20030055067A1/en not_active Abandoned
- 2002-04-01 KR KR1020037012936A patent/KR100607742B1/ko not_active Expired - Lifetime
- 2002-04-01 JP JP2002578726A patent/JP4308902B2/ja not_active Expired - Lifetime
- 2002-04-01 HU HU0400856A patent/HUP0400856A3/hu not_active Application Discontinuation
- 2002-04-01 AU AU2002257104A patent/AU2002257104B2/en not_active Expired
- 2002-04-01 EP EP02726689A patent/EP1372394A1/en not_active Ceased
- 2002-04-01 MX MXPA03009021A patent/MXPA03009021A/es active IP Right Grant
- 2002-04-02 PE PE2002000263A patent/PE20020994A1/es active IP Right Grant
- 2002-04-02 TW TW091106644A patent/TWI311464B/zh not_active IP Right Cessation
- 2002-04-02 AR ARP020101198A patent/AR033096A1/es not_active Application Discontinuation
-
2003
- 2003-10-01 ZA ZA2003/07684A patent/ZA200307684B/en unknown
- 2003-10-02 NO NO20034419A patent/NO20034419L/no not_active Application Discontinuation
-
2008
- 2008-02-18 JP JP2008036719A patent/JP2008120836A/ja active Pending
-
2011
- 2011-06-15 US US13/161,097 patent/US8263600B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030055067A1 (en) | 2003-03-20 |
| HUP0400856A2 (hu) | 2004-08-30 |
| CN100415234C (zh) | 2008-09-03 |
| KR100607742B1 (ko) | 2006-08-01 |
| CN1499930A (zh) | 2004-05-26 |
| AU2002257104B2 (en) | 2006-02-09 |
| WO2002080678A1 (en) | 2002-10-17 |
| NO20034419L (no) | 2003-12-02 |
| US20110244004A1 (en) | 2011-10-06 |
| EP1372394A1 (en) | 2004-01-02 |
| HUP0400856A3 (en) | 2012-09-28 |
| CA2443089C (en) | 2011-11-01 |
| MXPA03009021A (es) | 2004-02-12 |
| PL363965A1 (en) | 2004-11-29 |
| EP2090165A3 (en) | 2012-03-28 |
| NZ528363A (en) | 2005-04-29 |
| BR0208626A (pt) | 2004-03-09 |
| TWI311464B (en) | 2009-07-01 |
| PL212985B1 (pl) | 2012-12-31 |
| JP4308902B2 (ja) | 2009-08-05 |
| JP2008120836A (ja) | 2008-05-29 |
| CA2443089A1 (en) | 2002-10-17 |
| AR033096A1 (es) | 2003-12-03 |
| JP2004527525A (ja) | 2004-09-09 |
| KR20030087052A (ko) | 2003-11-12 |
| US8263600B2 (en) | 2012-09-11 |
| EP2090165A2 (en) | 2009-08-19 |
| NO20034419D0 (no) | 2003-10-02 |
| ZA200307684B (en) | 2005-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20020994A1 (es) | Composicion antifungal con aumentada biodisponibilidad | |
| EP0939618B1 (en) | Triclosan skin wash with enhanced efficacy | |
| AR078161A1 (es) | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. | |
| DK1988913T3 (da) | G-CSF-flydende formulering | |
| NO20015418D0 (no) | Karboksylsyrederivater som hemmer binding av integriner til deres reseptorer | |
| JP2004527525A5 (es) | ||
| AR030920A1 (es) | Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones | |
| AR084663A1 (es) | Preparados liofilizados de inhibidores de proteasomas | |
| UY27682A1 (es) | Composiciones farmacéuticas | |
| PE20040499A1 (es) | Nuevas formulaciones de liberacion prolongada inyectables | |
| AR006598A1 (es) | "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación" | |
| NO20022201L (no) | Lösninger inneholdende Epinastin | |
| NO20015419L (no) | Propionsyrederivater som hemmer binding av integriner til deres reseptorer | |
| AR078283A1 (es) | Formulaciones de suspension oral de dibenzazepina carboxamidas | |
| PE20010636A1 (es) | Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica | |
| CN102766540B (zh) | 液体酶稳定化添加剂及其制备方法和应用 | |
| AR020918A1 (es) | Composiciones atenuadas para dialisis | |
| PE20030545A1 (es) | Formulaciones de jarabe de ribavirina | |
| JPH0780760B2 (ja) | 安定化されたフエニレフリン系液剤 | |
| WO2004105492A8 (ja) | 消毒および／または殺菌用水性組成物 | |
| RU2008105323A (ru) | Консервирующая композиция для офтальмологического применения | |
| RU97107154A (ru) | Водные композиции, содержащие ципрофлоксацин, их применение и способ получения | |
| SE9904412D0 (sv) | Comminuted form | |
| WO2008050776A1 (en) | Ophthalmic aqeous liquid preparation | |
| JPH02105898A (ja) | 糖質分解酵素の安定化法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |