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PE20020975A1 - Derivados de ciclopropilindol como inhibidores selectivos de la recaptacion de serotonina - Google Patents

Derivados de ciclopropilindol como inhibidores selectivos de la recaptacion de serotonina

Info

Publication number
PE20020975A1
PE20020975A1 PE2002000243A PE2002000243A PE20020975A1 PE 20020975 A1 PE20020975 A1 PE 20020975A1 PE 2002000243 A PE2002000243 A PE 2002000243A PE 2002000243 A PE2002000243 A PE 2002000243A PE 20020975 A1 PE20020975 A1 PE 20020975A1
Authority
PE
Peru
Prior art keywords
alkyl
alkylene
cyclopropylindol
recaptation
serotonin
Prior art date
Application number
PE2002000243A
Other languages
English (en)
Inventor
Ronald J Mattson
Jonathan L Ditta
John D Catt
Derek J Denhart
Lawrence R Marcin
Dalton King
Jeffrey A Deskus
James R Epperson
Mendi A Higgins
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20020975A1 publication Critical patent/PE20020975A1/es

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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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Abstract

SE REFIERE A DERIVADOS DE CICLOPROPILINDOL DE FORMULA I, DONDE A1 ES ALQUILENO C1-C4, ENLACE; A3 ES ALQUILENO C1-C4, ALQUILIDENO C1-C4; A4 ES ALQUILENO C1-C4, ENLACE UNIDO A X, X1, X2; X, X1, X2, X3 SON C, CH; J ES ALQUILO C1-C4; p ES 0-1; R1 Y R2 SON H, ALQUILO C1-C3, CICLOALQUILO C3-C6, FENILO, O-FENILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C4; m ES 0-1; R4 Y R5 SON H, CIANO, HALO, NITRO, PERFLUOROALQUILO C1-C3, O PUEDEN ESTAR UNIDOS A X, X1, X2, X3; n ES 0-1; G ES N, O, S; G1 ES N, CH; Y ES DH; D ES C; Z ES EH; E ES C. SI G ES O, S; m ES CERO; SI G ES N, m ES 1; SI R1 ES NHCOO-ALQUILO C1-C4, ALQUIL C1-C4-NH-COO, ENTRE OTRAS CONDICIONES SON COMPUESTOS PREFERIDOS TRANS-2-[5-CIANOINDOL-3-IL]-1-(N,N-DIMETILAMINOMETIL)CICLOPROPANO; TRANS-(N,N-DIMETILAMINOMETIL)-2-[5-FLUOROINDOL-3-IL]CICLOPROPANO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DEL COMPUESTO Y DE LOS COMPUESTOS INTERMEDIOS. LOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA RECAPTACION DE SEROTONINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DEPRESION, DESORDENES DE ANSIEDAD, EYACULACION PREMATURA, INCONTINENCIA URINARIA, DOLOR CRONICO, DESORDEN OBSESIVO COMPULSIVO, DESORDENES DE LA ALIMENTACION
PE2002000243A 2001-03-29 2002-03-27 Derivados de ciclopropilindol como inhibidores selectivos de la recaptacion de serotonina PE20020975A1 (es)

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US27988801P 2001-03-29 2001-03-29
US29312201P 2001-05-23 2001-05-23
US32780401P 2001-10-09 2001-10-09

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EP (1) EP1373203A1 (es)
JP (1) JP2004531506A (es)
AR (1) AR035793A1 (es)
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CA (1) CA2442525A1 (es)
CZ (1) CZ20032644A3 (es)
EE (1) EE200300478A (es)
HU (1) HUP0400343A2 (es)
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PE (1) PE20020975A1 (es)
PL (1) PL364580A1 (es)
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WO (1) WO2002079152A1 (es)

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DE602004016491D1 (de) * 2003-05-09 2008-10-23 Esteve Labor Dr Verwendung von sulfonamid-derivate zur herstellung eines medikaments für die vorbeugung oder behandlung von essstörungen
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
ATE460415T1 (de) * 2004-11-29 2010-03-15 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und - indazole
EP1896076A2 (en) * 2005-06-27 2008-03-12 Daniel Drai Compositions and methods for enhancement of sexual function
EP1741708A1 (en) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
WO2007025144A1 (en) * 2005-08-24 2007-03-01 University Of Illinois - Chicago 5-ht2c receptor agonists as anorectic agents
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