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PE20020635A1 - Compuestos triciclicos como inhibidores de la farnesil transferasa - Google Patents

Compuestos triciclicos como inhibidores de la farnesil transferasa

Info

Publication number
PE20020635A1
PE20020635A1 PE2001001188A PE2001001188A PE20020635A1 PE 20020635 A1 PE20020635 A1 PE 20020635A1 PE 2001001188 A PE2001001188 A PE 2001001188A PE 2001001188 A PE2001001188 A PE 2001001188A PE 20020635 A1 PE20020635 A1 PE 20020635A1
Authority
PE
Peru
Prior art keywords
tricyclic compounds
inhibitors
farnesil
reaction mixture
transferasa
Prior art date
Application number
PE2001001188A
Other languages
English (en)
Inventor
F George Njoroge
Bancha Vibulbhan
Viyyoor M Girijavallabhan
Xiongwei Shi
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20020635A1 publication Critical patent/PE20020635A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE REFIERE A COMPUESTOS TRICICLICOS DE FORMULA I ENTRE OTROS Y UN PROCEDIMIENTO PARA LA PREPARACION DEL COMPUESTO (4) QUE COMPRENDE: a) DISOLVER EL COMPUESTO (3) EN UNA MEZCLA SOLVENTE QUE COMPRENDE UN SOLVENTE APROTICO APROPIADO COMO CH2CL2 Y DIMETILACETAMIDA; b) ENFRIAR LA MEZCLA DE REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE (-) 10°C y (+) 10°C; c) AGREGAR BROMURO DE TIONILO; d) AGITAR LA MEZCLA DE REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE (-) 10°C Y (+) 40°C; (e) BASIFICAR LA MEZCLA DE REACCION Y f) EXTRAER LA SOLUCION RESULTANTE CON UN SOLVENTE ORGANICO APROPIADO. LOS COMPUESTOS TRICICLICOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DEL CANCER
PE2001001188A 2000-11-29 2001-11-27 Compuestos triciclicos como inhibidores de la farnesil transferasa PE20020635A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25397100P 2000-11-29 2000-11-29

Publications (1)

Publication Number Publication Date
PE20020635A1 true PE20020635A1 (es) 2002-07-11

Family

ID=22962414

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001188A PE20020635A1 (es) 2000-11-29 2001-11-27 Compuestos triciclicos como inhibidores de la farnesil transferasa

Country Status (20)

Country Link
US (1) US6528523B2 (es)
EP (1) EP1337522B1 (es)
JP (1) JP2004514717A (es)
KR (1) KR20030060939A (es)
CN (1) CN1198816C (es)
AR (1) AR035660A1 (es)
AT (1) ATE371655T1 (es)
AU (2) AU2002235143B2 (es)
CA (1) CA2429720C (es)
DE (1) DE60130239T2 (es)
ES (1) ES2291368T3 (es)
HK (1) HK1054226A1 (es)
HU (1) HUP0302104A2 (es)
IL (1) IL155668A0 (es)
MX (1) MXPA03004878A (es)
NZ (1) NZ525572A (es)
PE (1) PE20020635A1 (es)
TW (1) TWI225058B (es)
WO (1) WO2002044164A1 (es)
ZA (1) ZA200303635B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051392A1 (en) 2003-11-20 2005-06-09 Children's Hospital Medical Center Gtpase inhibitors and methods of use
WO2007016539A2 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
EP4461315A3 (en) 2019-08-16 2025-03-05 Children's Hospital Medical Center Cdc-42 inhibitors for use in the treatment of age-related depression, sarcopenia or frailty

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698960B2 (en) * 1993-10-15 1998-11-12 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
EP1380581A1 (en) * 1995-12-22 2004-01-14 Schering Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
US5784442A (en) 1996-02-02 1998-07-21 Telefonaktiebologet Lm Ericsson (Publ) System and method for real-time billing in a radio telecommunications network
US5925757A (en) * 1996-07-26 1999-07-20 Schering Corporation Method for preparing carboxamides
US5945429A (en) 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
US6030982A (en) 1996-09-13 2000-02-29 Schering Corporationm Compounds useful for inhibition of farnesyl protein transferase
US5985879A (en) 1996-09-13 1999-11-16 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6040305A (en) 1996-09-13 2000-03-21 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6071907A (en) 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
IL133449A0 (en) * 1997-06-17 2001-04-30 Schering Corp Benzo (5, 6) cyclohepta (1, 2-b) pyridine derivatives as farnesyl protein transferase inhibitors
US6211193B1 (en) 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
NZ501619A (en) * 1997-06-17 2002-02-01 Schering Corp Tricyclic sulfonamide inhibitors of farnesyl-protein transferase
US5852034A (en) 1997-06-17 1998-12-22 Schering Corporation Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
US6239140B1 (en) 1997-06-17 2001-05-29 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5939416A (en) 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US6228865B1 (en) 1997-06-17 2001-05-08 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5925639A (en) 1997-06-17 1999-07-20 Schering Corporation Keto amide derivatives useful as farnesyl protein transferase inhibitors
US6358968B1 (en) 1997-06-17 2002-03-19 Schering Corporation N-substituted urea inhibitors of farnesyl-protein transferase
US6159984A (en) 1997-06-17 2000-12-12 Schering Corporation Farnesyl protein transferase inhibitors
US6051582A (en) 1997-06-17 2000-04-18 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6221322B1 (en) 1997-11-27 2001-04-24 Dowa Mining Co., Ltd Strontium nitrate and method for manufacturing same
US6096757A (en) 1998-12-21 2000-08-01 Schering Corporation Method for treating proliferative diseases
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US6410451B2 (en) 1999-09-27 2002-06-25 Lam Research Corporation Techniques for improving etching in a plasma processing chamber

Also Published As

Publication number Publication date
ZA200303635B (en) 2004-08-12
AU2002235143B2 (en) 2006-03-02
ES2291368T3 (es) 2008-03-01
AU3514302A (en) 2002-06-11
JP2004514717A (ja) 2004-05-20
WO2002044164A1 (en) 2002-06-06
DE60130239T2 (de) 2008-05-21
US20020115679A1 (en) 2002-08-22
NZ525572A (en) 2004-11-26
HUP0302104A2 (hu) 2003-09-29
US6528523B2 (en) 2003-03-04
EP1337522A1 (en) 2003-08-27
MXPA03004878A (es) 2003-08-19
CA2429720C (en) 2009-12-29
KR20030060939A (ko) 2003-07-16
CN1198816C (zh) 2005-04-27
CN1476444A (zh) 2004-02-18
DE60130239D1 (en) 2007-10-11
HK1054226A1 (zh) 2003-11-21
CA2429720A1 (en) 2002-06-06
EP1337522B1 (en) 2007-08-29
IL155668A0 (en) 2003-11-23
TWI225058B (en) 2004-12-11
ATE371655T1 (de) 2007-09-15
AR035660A1 (es) 2004-06-23

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