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PE20020584A1 - Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento - Google Patents

Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento

Info

Publication number
PE20020584A1
PE20020584A1 PE2001000863A PE2001000863A PE20020584A1 PE 20020584 A1 PE20020584 A1 PE 20020584A1 PE 2001000863 A PE2001000863 A PE 2001000863A PE 2001000863 A PE2001000863 A PE 2001000863A PE 20020584 A1 PE20020584 A1 PE 20020584A1
Authority
PE
Peru
Prior art keywords
oxo
sustained release
pyridin
ethyl
dosage form
Prior art date
Application number
PE2001000863A
Other languages
English (en)
Inventor
Ende Mary Tanya Am Am
Scott Max Herbig
William John Curatolo
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20020584A1 publication Critical patent/PE20020584A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UNA FORMA DE DOSIFICACION CON LIBERACION SOSTENIDA SOLIDA QUE COMPRENDE UN SECRETAGOGO DE LA HORMONA DE CRECIMIENTO TAL COMO 2-AMINO-N-[2-(3a-(R)-BENCIL-2-METIL-3-OXO-2,3,3a,4,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]-PIRIDIN-5-IL)-1-(R)-BENCILOXIMETIL-2-OXO-ETIL]-ISOBUTIRAMIDA; 2-AMINO-N-{1-(R)-(2,4-DIFLUORO-BENCILOXIMETIL)-2-OXO-2-[3-OXO-3a-(R)-PIRIDIN-2-ILMETIL-2-(2,2,2-TRIFLUORO-ETIL)-2,3,3a,4,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDIN-5-IL]-ETIL}-2-METIL-PROPIONAMIDA QUE SE CARACTERIZA POR TENER UNA CONCENTRACION PLASMATICA MAXIMA CMAX INFERIOR A 80% DE LA CMAX DE LA DOSIS ORAL CON LIBERACION INMEDIATA, QUE EXCEDE LA CONCENTRACION MINIMA EFICAZ DURANTE AT(T2-T1)QUE ES SUPERIOR EN 30 MINUTOS AL AT(T2-T1) DETERMINADO CON UNA FORMA DE DOSIFICACION CON LIBERACION INMEDIATA; LA VIDA MEDIA DE ELIMINACION ES INFERIOR A 6 HORAS; SE LIBERA 0,007 0,010 mg/HORA/Kg PARA UNA DOSIS DE 4mg; LA FORMA DE DOSIFICACION COMPRENDE: a)UNA MATRIZ QUE PERMANECE INTACTA DURANTE EL PERIODO DE LIBERACION SOSTENIDA; b)UN COMPRIMIDO DE MATRIZ DESINTEGRANTE; d)UN COMPRIMIDO DE MATRIZ PARCIALMENTE REVESTIDO CON UN POLIMERO QUE IMPIDE LA LIBERACION DEL SECRETAGOGO; e)COMPRIMIDO OSMOTICO, f)UN COMPRIMIDO DE NUCLEO HINCHABLE REVESTIDO CON MEMBRANA; f)MULTIPARTICULADO. TAMBIEN SE REFIERE A UNA FORMA DE DOSIFICACION QUE COMPRENDE UNA COMBINACION DE UNA PORCION DE LIBERACION INMEDIATA Y UNA PORCION DE LIBERACION SOSTENIDA
PE2001000863A 2000-08-30 2001-08-28 Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento PE20020584A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22907400P 2000-08-30 2000-08-30

Publications (1)

Publication Number Publication Date
PE20020584A1 true PE20020584A1 (es) 2002-07-06

Family

ID=22859744

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000863A PE20020584A1 (es) 2000-08-30 2001-08-28 Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento

Country Status (19)

Country Link
US (2) US6641840B2 (es)
EP (1) EP1313473A2 (es)
JP (1) JP2004507502A (es)
AP (1) AP2001002264A0 (es)
AR (2) AR035195A1 (es)
AU (1) AU2001276608A1 (es)
BR (1) BR0113626A (es)
CA (1) CA2420535A1 (es)
DO (1) DOP2001000241A (es)
GT (1) GT200100175A (es)
HN (1) HN2001000190A (es)
MX (1) MXPA03001771A (es)
PA (1) PA8526101A1 (es)
PE (1) PE20020584A1 (es)
SV (1) SV2002000615A (es)
TN (1) TNSN01130A1 (es)
TW (1) TW200412955A (es)
UY (1) UY26910A1 (es)
WO (1) WO2002017918A2 (es)

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