PE20020518A1 - Formulacion en solucion inhalable con una sal de tiotropio - Google Patents

Formulacion en solucion inhalable con una sal de tiotropio

Info

Publication number: PE20020518A1
Authority: PE; Peru
Prior art keywords: salt; formulation; tiotrope; solvent; water
Prior art date: 2000-10-31

Application number

PE2001001072A

Other languages

English (en)

Spanish (es)

Inventor

Karin Drechsel

Barbara Niklaus-Humke

Christel Schmelzer

Petra Barth

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-31

Filing date

2001-10-29

Publication date

2002-07-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7661727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20020518(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-10-29 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2002-07-12 Publication of PE20020518A1 publication Critical patent/PE20020518A1/es

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PE2001001072A 2000-10-31 2001-10-29 Formulacion en solucion inhalable con una sal de tiotropio PE20020518A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10054042		2000-10-31

Publications (1)

Publication Number	Publication Date
PE20020518A1 true PE20020518A1 (es)	2002-07-12

Family

ID=7661727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE2001001072A PE20020518A1 (es)	2000-10-31	2001-10-29	Formulacion en solucion inhalable con una sal de tiotropio

Country Status (32)

Country	Link
EP (1)	EP1335729A2 (et)
JP (1)	JP4559703B2 (et)
KR (1)	KR100983208B1 (et)
CN (1)	CN1237970C (et)
AR (1)	AR038765A1 (et)
AU (2)	AU2002221741B2 (et)
BG (1)	BG66425B1 (et)
BR (1)	BR0115016A (et)
CA (1)	CA2427583C (et)
CZ (1)	CZ305033B6 (et)
DE (1)	DE10152369A1 (et)
EA (1)	EA009068B1 (et)
EC (1)	ECSP034570A (et)
EE (1)	EE05343B1 (et)
HR (1)	HRP20030337A2 (et)
HU (1)	HUP0301377A3 (et)
IL (2)	IL155676A0 (et)
ME (1)	ME00242B (et)
MX (1)	MXPA03003750A (et)
MY (1)	MY132777A (et)
NO (1)	NO332524B1 (et)
NZ (1)	NZ526024A (et)
PE (1)	PE20020518A1 (et)
PL (1)	PL361001A1 (et)
SA (1)	SA01220503B1 (et)
SK (1)	SK288031B6 (et)
TW (1)	TWI296934B (et)
UA (1)	UA76435C2 (et)
UY (1)	UY26991A1 (et)
WO (1)	WO2002036591A2 (et)
YU (1)	YU33103A (et)
ZA (1)	ZA200303045B (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20070092334A (ko)	2000-04-28	2007-09-12	코산 바이오사이언시즈, 인코포레이티드	폴리케타이드의 제조방법
US20030235538A1 (en)	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
EP1677778A2 (en) *	2003-10-09	2006-07-12	Inverseon, Inc.	Method of treating airway diseases with beta-adrenergic inverse agonists
SE0303269L (sv) *	2003-12-03	2005-06-04	Microdrug Ag	Medicinsk produkt
SI1863476T1 (sl) *	2005-03-16	2016-05-31	Meda Pharma Gmbh & Co. Kg	Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni
US20070274925A1 (en) *	2006-05-26	2007-11-29	Dey, L.P.	Nebulizable compositions of quaternary ammonium muscarinic receptor antagonists
CN100446770C (zh) *	2007-01-10	2008-12-31	上海现代药物制剂工程研究中心有限公司	丙酸培氯米松水雾剂
TR200907237A2 (tr) *	2009-09-23	2011-04-21	B�Lg�� Mahmut	Tiotropyum kuru toz kombinasyonu
CN116173025A (zh) *	2018-07-26	2023-05-30	四川海思科制药有限公司	一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
WO2020019953A1 (zh) *	2018-07-26	2020-01-30	四川海思科制药有限公司	一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0504112A3 (en) *	1991-03-14	1993-04-21	Ciba-Geigy Ag	Pharmaceutical aerosol formulations
DE4203306A1 (de) *	1992-02-06	1993-08-12	Ig Spruehtechnik Gmbh	Asthma oder pulmonal-aerosolzubereitungen mit lecithin
JP3875993B2 (ja) *	1995-06-27	2007-01-31	ベーリンガーインゲルハイムコマンディトゲゼルシャフト	噴射剤を含まないエアゾールを製造するための新規で安定な医薬調製物
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
BR9709650A (pt) *	1996-06-04	1999-08-10	Procter & Gamble	Aerosol nasal contendo um esteróide intransal e um anti-histamínico
DE19653969A1 (de) *	1996-12-20	1998-06-25	Boehringer Ingelheim Kg	Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
JPH10298107A (ja) *	1997-04-25	1998-11-10	Taisho Pharmaceut Co Ltd	医薬組成物
DK1102579T3 (da) *	1998-08-04	2003-07-14	Jago Res Ag	Medicinske aerosolformuleringer
DE19847968A1 (de) *	1998-10-17	2000-04-20	Boehringer Ingelheim Pharma	Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

2001
- 2001-10-24 BR BR0115016-2A patent/BR0115016A/pt active Search and Examination
- 2001-10-24 DE DE10152369A patent/DE10152369A1/de not_active Withdrawn
- 2001-10-24 CZ CZ2003-1487A patent/CZ305033B6/cs not_active IP Right Cessation
- 2001-10-24 EA EA200300483A patent/EA009068B1/ru not_active IP Right Cessation
- 2001-10-24 NZ NZ526024A patent/NZ526024A/en not_active IP Right Cessation
- 2001-10-24 IL IL15567601A patent/IL155676A0/xx unknown
- 2001-10-24 PL PL01361001A patent/PL361001A1/xx not_active Application Discontinuation
- 2001-10-24 HR HR20030337A patent/HRP20030337A2/hr not_active Application Discontinuation
- 2001-10-24 CA CA002427583A patent/CA2427583C/en not_active Expired - Fee Related
- 2001-10-24 KR KR1020037006001A patent/KR100983208B1/ko not_active Expired - Lifetime
- 2001-10-24 SK SK526-2003A patent/SK288031B6/sk not_active IP Right Cessation
- 2001-10-24 ME MEP-2008-407A patent/ME00242B/me unknown
- 2001-10-24 AU AU2002221741A patent/AU2002221741B2/en not_active Expired
- 2001-10-24 HU HU0301377A patent/HUP0301377A3/hu unknown
- 2001-10-24 JP JP2002539350A patent/JP4559703B2/ja not_active Expired - Lifetime
- 2001-10-24 EE EEP200300202A patent/EE05343B1/et unknown
- 2001-10-24 EP EP01992710A patent/EP1335729A2/de not_active Ceased
- 2001-10-24 AU AU2174102A patent/AU2174102A/xx active Pending
- 2001-10-24 WO PCT/EP2001/012296 patent/WO2002036591A2/de not_active Ceased
- 2001-10-24 MX MXPA03003750A patent/MXPA03003750A/es active IP Right Grant
- 2001-10-24 UA UA2003054960A patent/UA76435C2/uk unknown
- 2001-10-24 CN CNB018183271A patent/CN1237970C/zh not_active Expired - Lifetime
- 2001-10-24 YU YU33103A patent/YU33103A/sh unknown
- 2001-10-29 PE PE2001001072A patent/PE20020518A1/es active IP Right Grant
- 2001-10-29 UY UY26991A patent/UY26991A1/es not_active Application Discontinuation
- 2001-10-29 TW TW090126752A patent/TWI296934B/zh not_active IP Right Cessation
- 2001-10-29 MY MYPI20014987A patent/MY132777A/en unknown
- 2001-10-31 AR ARP010105088A patent/AR038765A1/es not_active Application Discontinuation
- 2001-11-03 SA SA01220503A patent/SA01220503B1/ar unknown
2003
- 2003-04-16 BG BG107726A patent/BG66425B1/bg unknown
- 2003-04-17 ZA ZA200303045A patent/ZA200303045B/xx unknown
- 2003-04-28 EC EC2003004570A patent/ECSP034570A/es unknown
- 2003-04-29 NO NO20031914A patent/NO332524B1/no not_active IP Right Cessation
- 2003-04-30 IL IL155676A patent/IL155676A/en active IP Right Grant

Also Published As

Publication number	Publication date
KR20040010552A (ko)	2004-01-31
EP1335729A2 (de)	2003-08-20
MY132777A (en)	2007-10-31
SK288031B6 (sk)	2012-12-03
CA2427583A1 (en)	2002-05-10
CN1473044A (zh)	2004-02-04
CA2427583C (en)	2008-02-12
YU33103A (sh)	2006-05-25
DE10152369A1 (de)	2002-05-08
BG107726A (bg)	2004-11-30
NO20031914L (no)	2003-06-23
CN1237970C (zh)	2006-01-25
WO2002036591A3 (de)	2002-07-25
BG66425B1 (bg)	2014-04-30
IL155676A (en)	2012-05-31
BR0115016A (pt)	2005-05-03
EA200300483A1 (ru)	2003-12-25
ZA200303045B (en)	2004-04-22
MXPA03003750A (es)	2004-10-15
TWI296934B (en)	2008-05-21
UA76435C2 (en)	2006-08-15
IL155676A0 (en)	2003-11-23
NO332524B1 (no)	2012-10-08
JP4559703B2 (ja)	2010-10-13
EA009068B1 (ru)	2007-10-26
UY26991A1 (es)	2002-06-20
HRP20030337A2 (en)	2005-04-30
CZ305033B6 (cs)	2015-04-08
AU2174102A (en)	2002-05-15
AU2002221741B2 (en)	2007-04-05
NZ526024A (en)	2005-10-28
KR100983208B1 (ko)	2010-09-20
ECSP034570A (es)	2003-06-25
SA01220503B1 (ar)	2007-03-10
SK5262003A3 (en)	2003-10-07
NO20031914D0 (no)	2003-04-29
CZ20031487A3 (cs)	2003-09-17
WO2002036591A2 (de)	2002-05-10
HK1060569A1 (en)	2004-08-13
JP2004523482A (ja)	2004-08-05
EE200300202A (et)	2003-10-15
ME00242B (me)	2011-05-10
EE05343B1 (et)	2010-10-15
PL361001A1 (en)	2004-09-20
AR038765A1 (es)	2005-01-26
MEP40708A (en)	2011-02-10
HUP0301377A3 (en)	2005-12-28
HUP0301377A2 (hu)	2003-10-28

Publication	Publication Date	Title
PE20120023A1 (es)	2012-02-13	Formulacion farmaceutica para aerosoles con dos o mas principios activos y al menos una sustancia tensioactiva
PE20020518A1 (es)	2002-07-12	Formulacion en solucion inhalable con una sal de tiotropio
Miller et al.	1973	The pressure reversal of general anesthesia and the critical volume hypothesis
BRPI1006790B8 (pt)	2021-05-25	método para desenvolver uma composição farmacêutica líquida a ser aplicada na pele como uma espuma e composição adequada para uso tópico
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PE63998A1 (es)	1998-10-30	Composiciones anti-fungosas
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ES2097548T3 (es)	1997-04-01	Suspensiones estables de microburbujas como agentes de intensificacion para ecografia ultrasonica.
BRPI0413957A (pt)	2006-10-31	processo para preparar diterpenos solúveis em água, solução aquosa e suas aplicações
MXPA01000601A (es)	2002-04-08	Composicion farmaceutica estabilizada en forma liofilizada.
Caruso-Neves et al.	2000	Angiotensin-(1–7) modulates the ouabain-insensitive Na+-ATPase activity from basolateral membrane of the proximal tubule
Sriram et al.	2021	Inhaled β2 adrenergic agonists and other cAMP-elevating agents: therapeutics for alveolar injury and acute respiratory disease syndrome?
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ATE350024T1 (de)	2007-01-15	Flüssige zubereitung enthaltend tobramycin
PE20030092A1 (es)	2003-03-24	Formulacion de una solucion de inhalacion con una sal de tiotropio
BRPI0403316A (pt)	2005-06-21	Formulações de solução farmacêutica em aerossol adequadas para inalação oral ou nasal contendo glucocorticóides estáveis ao armazenamento; método para formulações estabilizantes e uso de um estabilizador
Audonnet-Blaise et al.	2006	Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle metabolism
NZ791927A (en)	2025-09-26	Liquid formulations of glucagon analogues
REICH et al.	1953	The use of 2-ethylhexanol in acute pulmonary edema
Hutchins et al.	1956	A comparison of the stability of cyanocobalamin and its analogs in ascorbate solution
Bleicher et al.	1966	Effect of Mono-and Divalent Cations on in vitro Lipolysis.

Legal Events

Date	Code	Title	Description
2005-06-22	FG	Grant, registration