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PE20020513A1 - 2,4,8-TRISUSTITUIDE-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA COMPOUNDS - Google Patents

2,4,8-TRISUSTITUIDE-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA COMPOUNDS

Info

Publication number
PE20020513A1
PE20020513A1 PE2001001042A PE2001001042A PE20020513A1 PE 20020513 A1 PE20020513 A1 PE 20020513A1 PE 2001001042 A PE2001001042 A PE 2001001042A PE 2001001042 A PE2001001042 A PE 2001001042A PE 20020513 A1 PE20020513 A1 PE 20020513A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrimidin
pyrid
ona
aryl
Prior art date
Application number
PE2001001042A
Other languages
Spanish (es)
Inventor
Jerry L Adams
Jeffrey C Boehm
Ralph Hall
Qi Jin
Jiri Kasparec
Domingos J Silva
John J Taggart
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20020513A1 publication Critical patent/PE20020513A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE 2,4,8-TRISUSTITUIDA-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA DE FORMULA I, Ia DONDE R1 ES ARILO, HETEROARILO; R2 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C7, CICLOALQUIL C3-C7-ALQUILO, ARILO, ARIL-ALQUILO C1-C10, ENTRE OTROS; R3 ES ALQUILO C1-C10, CICLOALQUILO C3-C7, CICLOALQUILO C3-C7-ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C10, ENTRE OTROS; X ES N(R10), O, S(O)m, CR10R20, ENTRE OTROS; R10 Y R20 ES H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 2-METILSULFANIL-4,8-DIFENIL-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA, 2-(2-DIETILAMINO-ETILAMINO)-4,8-DIFENIL-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA, 8-(2,6-DIFLUOROFENIL)-4-(4-FLUORO-2-METIL-FENIL)-2-METOXI-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA CSBP/p38 QUINASA Y SON UTILES PARA EL TRATAMIENTO DE ARTRITIS, SINDROME DE REITER, GOTAREFERS TO 2,4,8-TRISUSTITUIDE-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA COMPOUNDS OF FORMULA I, WHERE R1 IS ARYL, HETEROARYL; R2 IS H, C1-C10 ALKYL, C3-C7 CYCLOALKYL, C3-C7 CYCLOALKYL-ALKYL, ARYL, C1-C10 ARYL-ALKYL, AMONG OTHERS; R3 IS C1-C10 ALKYL, C3-C7 CYCLOALKYL, C3-C7 CYCLOALKYL-C1-C4 ALKYL, ARYL, ARYL-C1-C10 ALKYL, AMONG OTHERS; X IS N (R10), O, S (O) m, CR10R20, AMONG OTHERS; R10 AND R20 IS H, C1-C4 ALKYL. PREFERRED COMPOUNDS ARE 2-METHYLSULPHANIL-4,8-DIPHENYL-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA, 2- (2-DIETHYLAMINE-ETHYLAMINE) -4,8-DIPHENYL-8H-PYRID [2 , 3-d] PYRIMIDIN-7-ONA, 8- (2,6-DIFLUOROPHENYL) -4- (4-FLUORO-2-METHYL-PHENYL) -2-METHOXY-8H-PYRIDO [2,3-d] PYRIMIDIN -7-ONA, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS ARE INHIBITORS OF CSBP / p38 KINASE AND ARE USEFUL FOR THE TREATMENT OF ARTHRITIS, REITER'S SYNDROME, Gout

PE2001001042A 2000-10-23 2001-10-19 2,4,8-TRISUSTITUIDE-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA COMPOUNDS PE20020513A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24246100P 2000-10-23 2000-10-23
US31034901P 2001-08-06 2001-08-06

Publications (1)

Publication Number Publication Date
PE20020513A1 true PE20020513A1 (en) 2002-08-24

Family

ID=38812518

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001042A PE20020513A1 (en) 2000-10-23 2001-10-19 2,4,8-TRISUSTITUIDE-8H-PYRID [2,3-d] PYRIMIDIN-7-ONA COMPOUNDS

Country Status (6)

Country Link
AR (1) AR035592A1 (en)
MY (1) MY145907A (en)
PE (1) PE20020513A1 (en)
SI (1) SI1333833T1 (en)
TW (2) TWI331149B (en)
UY (1) UY26980A1 (en)

Also Published As

Publication number Publication date
SI1333833T1 (en) 2011-12-30
TWI298722B (en) 2008-07-11
MY145907A (en) 2012-05-15
TW200815433A (en) 2008-04-01
UY26980A1 (en) 2002-06-20
TWI331149B (en) 2010-10-01
AR035592A1 (en) 2004-06-16

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed