PE20020424A1 - Procedimiento para la preparacion de formulaciones en polvo - Google Patents
Procedimiento para la preparacion de formulaciones en polvoInfo
- Publication number
- PE20020424A1 PE20020424A1 PE2001001002A PE2001001002A PE20020424A1 PE 20020424 A1 PE20020424 A1 PE 20020424A1 PE 2001001002 A PE2001001002 A PE 2001001002A PE 2001001002 A PE2001001002 A PE 2001001002A PE 20020424 A1 PE20020424 A1 PE 20020424A1
- Authority
- PE
- Peru
- Prior art keywords
- particle size
- active principle
- substance
- procedure
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 230000003454 betamimetic effect Effects 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 229940052760 dopamine agonists Drugs 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE FORMULACIONES EN POLVOS DE INHALACION, CARACTERIZADO PORQUE N+m PORCIONES DE APROXIMADAMENTE IGUAL TAMANO DE SUSTANCIA CON UNA DISTRIBUCION MAYOR DEL TAMANO DE PARTICULAS (COADYUVANTE) Y N PORCIONES DE IGUAL TAMANO DE UNA SUSTANCIA CON UNA DISTRIBUCION MENOR DEL TAMANO DE PARTICULAS (PRINCIPIO ACTIVO) SE ANADEN DE FORMA INTERMITENTE EN CAPAS POR MEDIO DE UN DISPOSITIVO DE TAMIZADO ADECUADO A UN RECIPIENTE DE MEZCLA Y, DESPUES DE LA ADICION COMPLETA , LAS 2N+m CAPAS DE LOS DOS COMPONENTES SE MEZCLAN EFECTUANDOSE PRIMERAMENTE LA ADICION DE UNA PORCION DE LA SUSTANCIA CON UN TAMANO DE PARTICULAS MAYOR SIENDO N UN NUMERO ENTERO MAYOR QUE 0 PREFERIBLEMENTE MAYOR QUE 5 Y m ES 0-1. SE OBTIENEN POLVOS DE INHALACION QUE CONTIENEN MENOS DE 5% DE PREFERENCIA 2% DEL PRINCIPIO ACTIVO. EL PRINCIPIO ACTIVO PRESENTA UN TAMANO DE PARTICULAS DE 0,5um A 10 um, EL COADYUVANTE UTILIZADO TIENE UN TAMANO MEDIO DE 10 A 100um. EL PRINCIPIO ACTIVO SE SELECCIONADA DE COMPUESTOS BETAMIMETICOS, ANTICOLINERGICOS, CORTICOSTEROIDES Y AGONISTAS DE DOPAMINA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10050635 | 2000-10-12 | ||
| DE2001138022 DE10138022A1 (de) | 2001-08-10 | 2001-08-10 | Verfahren zur Herstellung von Pulverformulierungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020424A1 true PE20020424A1 (es) | 2002-07-02 |
Family
ID=26007343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001002A PE20020424A1 (es) | 2000-10-12 | 2001-10-10 | Procedimiento para la preparacion de formulaciones en polvo |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US6585959B2 (es) |
| EP (1) | EP1326585B2 (es) |
| JP (2) | JP4986369B2 (es) |
| KR (1) | KR100849837B1 (es) |
| CN (1) | CN1269470C (es) |
| AR (1) | AR034166A1 (es) |
| AT (1) | ATE319422T1 (es) |
| AU (2) | AU2002218220B2 (es) |
| BG (1) | BG66194B1 (es) |
| BR (1) | BR0114316A (es) |
| CA (1) | CA2425005C (es) |
| CY (1) | CY1105037T1 (es) |
| CZ (1) | CZ300022B6 (es) |
| DE (1) | DE50109178D1 (es) |
| DK (1) | DK1326585T4 (es) |
| EA (1) | EA004689B1 (es) |
| EE (1) | EE05146B1 (es) |
| EG (1) | EG24478A (es) |
| ES (1) | ES2259046T5 (es) |
| HR (1) | HRP20030277B1 (es) |
| HU (1) | HU229512B1 (es) |
| IL (2) | IL154919A0 (es) |
| ME (1) | ME02762B (es) |
| MX (1) | MXPA03003219A (es) |
| MY (1) | MY155912A (es) |
| NO (1) | NO333719B1 (es) |
| NZ (1) | NZ525781A (es) |
| PE (1) | PE20020424A1 (es) |
| PL (1) | PL204733B1 (es) |
| PT (1) | PT1326585E (es) |
| RS (1) | RS50495B (es) |
| SA (1) | SA01220518B1 (es) |
| SI (1) | SI1326585T2 (es) |
| SK (1) | SK285841B6 (es) |
| TW (1) | TWI283180B (es) |
| UA (1) | UA75375C2 (es) |
| UY (1) | UY26960A1 (es) |
| WO (1) | WO2002030390A2 (es) |
| ZA (1) | ZA200301349B (es) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3477A1 (es) * | 2000-10-12 | 2002-04-18 | ||
| US6443152B1 (en) * | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
| CA2445650A1 (en) * | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways |
| US20030070679A1 (en) * | 2001-06-01 | 2003-04-17 | Boehringer Ingelheim Pharma Kg | Capsules containing inhalable tiotropium |
| US20030008001A1 (en) * | 2001-06-13 | 2003-01-09 | Boehringer Ingelheim Pharma Kg | Process for cleaning hard gelatine capsules |
| US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| DE10141377A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| DE10141376A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Inhalationspulvern |
| US7309707B2 (en) * | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
| US7244415B2 (en) * | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
| MXPA04009583A (es) * | 2002-04-04 | 2005-01-11 | Boehringer Ingelheim Pharma | Nuevas formulaciones en polvo adecuadas para inhalacion. |
| GB0219513D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions including coarse carrier |
| US20050158248A1 (en) * | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
| JP4744876B2 (ja) * | 2002-08-21 | 2011-08-10 | ノートン・ヘルスケアー リミテッド | 乾燥粉末吸入組成物の製造方法 |
| MXPA05001903A (es) * | 2002-08-21 | 2005-04-28 | Norton Healthcare Ltd | Composicion para inhalacion. |
| GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| US7763280B2 (en) | 2002-11-28 | 2010-07-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing powder formulation for inhalation |
| DE10255387A1 (de) * | 2002-11-28 | 2004-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Tiotropium-haltige Pulverformulierung für die Inhalation |
| UA83813C2 (ru) * | 2002-12-20 | 2008-08-26 | Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг | Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола |
| DE10317461A1 (de) | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung |
| US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
| US7462367B2 (en) | 2003-07-11 | 2008-12-09 | Boehringer Ingelheim International Gmbh | Anticholinergic powder formulations for inhalation |
| DE10331350A1 (de) * | 2003-07-11 | 2005-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverformulierungen für die Inhalation enthaltend ein neues Anticholinergikum |
| DK1699434T3 (da) * | 2003-09-02 | 2011-05-30 | Norton Healthcare Ltd | Fremgangsmåde til fremstilling af et lægemiddel |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| US8686148B2 (en) | 2003-11-03 | 2014-04-01 | Boehringer Ingelheim International Gmbh | Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof |
| PE20050485A1 (es) | 2003-11-03 | 2005-10-05 | Boehringer Ingelheim Int | Nuevas sales de tiotropio, procedimiento para su preparacion, asi como formulaciones medicamentosas que las contienen |
| CA2547245A1 (en) * | 2003-12-03 | 2005-06-16 | Microdrug Ag | Pre-metered dry powder inhaler for moisture-sensitive medicaments |
| DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| US9365905B2 (en) | 2005-02-10 | 2016-06-14 | Dmv-Fonterra Excipients Technology Gmbh | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
| GB0507835D0 (en) * | 2005-04-18 | 2005-05-25 | Solexa Ltd | Method and device for nucleic acid sequencing using a planar wave guide |
| WO2006117299A2 (en) | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
| DE102005059602A1 (de) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mikronisierung |
| ES2569359T3 (es) | 2007-07-06 | 2016-05-10 | Vectura Delivery Devices Limited | Inhalador |
| US20100255307A1 (en) * | 2007-07-27 | 2010-10-07 | Cargill Inc. | Micronization of polyols |
| EP2082768A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082767A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082766A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Blister Strip Coil Forming |
| EP2082771A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082772A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| EP2662116B1 (en) | 2008-05-09 | 2022-09-21 | Nuvaira, Inc. | Systems and assemblies for treating a bronchial tree |
| TWI470107B (zh) * | 2008-07-24 | 2015-01-21 | 液態空氣喬治斯克勞帝方法研究開發股份有限公司 | 用於沉積含過渡金屬之膜的環戊二烯基過渡金屬前驅物 |
| TWI491416B (zh) | 2008-12-24 | 2015-07-11 | Daiichi Sankyo Co Ltd | 吸入用乾燥粉末醫藥組成物 |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| WO2011056684A2 (en) | 2009-10-27 | 2011-05-12 | Innovative Pulmonary Solutions, Inc. | Delivery devices with coolable energy emitting assemblies |
| CA2780608C (en) | 2009-11-11 | 2019-02-26 | Innovative Pulmonary Solutions, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| EP2575786B1 (en) | 2010-06-03 | 2017-11-15 | Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. | Process for dry powder formulations |
| TR201007251A2 (tr) * | 2010-09-01 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Kalsiyum kanal blokörü formülasyonu. |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| WO2016005443A1 (en) | 2014-07-09 | 2016-01-14 | Arven Ilac Sanayi Ve Ticaret A.S. | A process for the preparation of formulations for inhalation |
| PL3175842T3 (pl) * | 2015-12-03 | 2020-06-29 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Sposób mieszania suchego proszku |
| WO2020013793A2 (en) * | 2018-07-12 | 2020-01-16 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising dopamine agonists |
| WO2022146255A1 (en) * | 2020-12-31 | 2022-07-07 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for the preparation of dry powder compositions for inhalation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| US3860618A (en) | 1967-08-08 | 1975-01-14 | Philip Saxton Hartley | Chromone |
| US3957965A (en) | 1967-08-08 | 1976-05-18 | Fisons Limited | Sodium chromoglycate inhalation medicament |
| BE891013A (fr) † | 1980-11-05 | 1982-05-05 | Fisons Ltd | Compositions pharmaceutique |
| JPS60150823A (ja) * | 1984-01-17 | 1985-08-08 | Satake Eng Co Ltd | 穀物混合装置 |
| JPH0439388A (ja) * | 1990-06-04 | 1992-02-10 | Teijin Ltd | 土砂と繊維状物との混合方法 |
| DE4140689B4 (de) * | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| JPH06198156A (ja) * | 1993-01-06 | 1994-07-19 | Nagasaki Pref Gov | 噴霧積層混合器 |
| IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| NZ511527A (en) | 1998-11-13 | 2002-10-25 | Jago Res A | Dry powder for inhalation |
| GB9902689D0 (en) | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
-
2001
- 2001-09-10 UA UA2003054184A patent/UA75375C2/uk unknown
- 2001-10-09 BR BR0114316-6A patent/BR0114316A/pt not_active Application Discontinuation
- 2001-10-09 ME MEP-2008-427A patent/ME02762B/me unknown
- 2001-10-09 CA CA 2425005 patent/CA2425005C/en not_active Expired - Lifetime
- 2001-10-09 CN CNB01817146XA patent/CN1269470C/zh not_active Expired - Lifetime
- 2001-10-09 AU AU2002218220A patent/AU2002218220B2/en not_active Expired
- 2001-10-09 SI SI200130509T patent/SI1326585T2/sl unknown
- 2001-10-09 DE DE50109178T patent/DE50109178D1/de not_active Expired - Lifetime
- 2001-10-09 PT PT01986599T patent/PT1326585E/pt unknown
- 2001-10-09 NZ NZ525781A patent/NZ525781A/en not_active IP Right Cessation
- 2001-10-09 AT AT01986599T patent/ATE319422T1/de active
- 2001-10-09 EE EEP200300170A patent/EE05146B1/xx unknown
- 2001-10-09 ES ES01986599T patent/ES2259046T5/es not_active Expired - Lifetime
- 2001-10-09 EA EA200300429A patent/EA004689B1/ru not_active IP Right Cessation
- 2001-10-09 KR KR1020037005039A patent/KR100849837B1/ko not_active Expired - Lifetime
- 2001-10-09 RS YUP-274/03A patent/RS50495B/sr unknown
- 2001-10-09 SK SK437-2003A patent/SK285841B6/sk not_active IP Right Cessation
- 2001-10-09 TW TW090124981A patent/TWI283180B/zh not_active IP Right Cessation
- 2001-10-09 MX MXPA03003219A patent/MXPA03003219A/es active IP Right Grant
- 2001-10-09 EP EP01986599A patent/EP1326585B2/de not_active Expired - Lifetime
- 2001-10-09 HR HR20030277A patent/HRP20030277B1/xx not_active IP Right Cessation
- 2001-10-09 IL IL15491901A patent/IL154919A0/xx active IP Right Grant
- 2001-10-09 WO PCT/EP2001/011636 patent/WO2002030390A2/de not_active Ceased
- 2001-10-09 JP JP2002533833A patent/JP4986369B2/ja not_active Expired - Lifetime
- 2001-10-09 HU HU0301268A patent/HU229512B1/hu unknown
- 2001-10-09 PL PL362511A patent/PL204733B1/pl unknown
- 2001-10-09 AU AU1822002A patent/AU1822002A/xx active Pending
- 2001-10-09 DK DK01986599.7T patent/DK1326585T4/da active
- 2001-10-09 CZ CZ20031024A patent/CZ300022B6/cs not_active IP Right Cessation
- 2001-10-10 MY MYPI20014704A patent/MY155912A/en unknown
- 2001-10-10 EG EG2001101063A patent/EG24478A/xx active
- 2001-10-10 PE PE2001001002A patent/PE20020424A1/es active IP Right Grant
- 2001-10-10 UY UY26960A patent/UY26960A1/es not_active IP Right Cessation
- 2001-10-11 US US09/977,911 patent/US6585959B2/en not_active Ceased
- 2001-10-12 AR ARP010104784A patent/AR034166A1/es unknown
- 2001-11-11 SA SA01220518A patent/SA01220518B1/ar unknown
-
2003
- 2003-02-19 ZA ZA2003/01349A patent/ZA200301349B/en unknown
- 2003-03-13 IL IL154919A patent/IL154919A/en unknown
- 2003-03-26 BG BG107673A patent/BG66194B1/bg unknown
- 2003-04-11 NO NO20031692A patent/NO333719B1/no not_active IP Right Cessation
-
2004
- 2004-01-28 US US10/766,748 patent/USRE38912E1/en not_active Expired - Lifetime
-
2006
- 2006-05-19 CY CY20061100654T patent/CY1105037T1/el unknown
-
2009
- 2009-06-08 JP JP2009136927A patent/JP2009197025A/ja active Pending
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