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PE20011167A1 - PHARMACEUTICAL COMPOSITIONS INCLUDING AN ALPHA-ADRENORECEPTOR ANTAGONIST AND A MUSCARINAL ANTAGONIST FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA - Google Patents

PHARMACEUTICAL COMPOSITIONS INCLUDING AN ALPHA-ADRENORECEPTOR ANTAGONIST AND A MUSCARINAL ANTAGONIST FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

Info

Publication number
PE20011167A1
PE20011167A1 PE2001000130A PE2001000130A PE20011167A1 PE 20011167 A1 PE20011167 A1 PE 20011167A1 PE 2001000130 A PE2001000130 A PE 2001000130A PE 2001000130 A PE2001000130 A PE 2001000130A PE 20011167 A1 PE20011167 A1 PE 20011167A1
Authority
PE
Peru
Prior art keywords
antagonist
alpha
adrenoreceptor
prostatic hyperplasia
selective
Prior art date
Application number
PE2001000130A
Other languages
Spanish (es)
Inventor
Michael Grant Wyllie
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22663745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20011167(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011167A1 publication Critical patent/PE20011167A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN ANTAGONISTA DEL ALFA-ADRENORRECEPTOR TAL COMO 4-AMINO-6,7-DIMETOXI-2-(5-METANOSULFONAMIDO-1,2,3,4-TETRAHIDROISOQUINOL-2-IL)-5-(2-PIRIDIL) QUINAZOLINA, DOXAZOSINA, TERAZOSINA, ABANOQUIL, PRAZOSINA, INDORAMINA Y b) UN ANTAGONISTA MUSCARINICO TAL COMO DARIFENACINA, TOLTERODINA Y OXIBUTININA. EL ANTAGONISTA DEL ALFA-ADRENORECEPTOR PUEDE SER NO SELECTIVO O SELECTIVO PARA EL RECEPTOR O-1 Y EL ANTAGONISTA MUSCARINICO PUEDE SER NO SELECTIVO O SELECTIVO PARA LOS RECEPTORES M3. LA COMPOSICION FARMACEUTICA ES UTIL PARA TRATAR LOS SINTOMAS DEL TRACTO URINARIO INFERIOR ASOCIADOS CON HIPERPLASIA PROSTATICA BENINGA (HPB)REFERS TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES: A) AN ANTAGONIST OF ALPHA-ADRENORECEPTOR SUCH AS 4-AMINO-6,7-DIMETOXI-2- (5-METHANOSULFONAMIDO-1,2,3,4-TETRAHIDROISOQUINOL-2-IL) -5- (2-PYRIDYL) QUINAZOLINE, DOXAZOSINE, TERAZOSINE, ABANOQUIL, PRAZOSINE, INDORAMINE AND b) A MUSCARINE ANTAGONIST SUCH AS DARIPHENACINE, TOLTERODINE AND OXIBUTININ. THE ALPHA-ADRENORECEPTOR ANTAGONIST MAY BE NON-SELECTIVE OR SELECTIVE FOR THE O-1 RECEPTOR AND THE MUSCARINIC ANTAGONIST MAY BE NON-SELECTIVE OR SELECTIVE FOR M3 RECEPTORS. THE PHARMACEUTICAL COMPOSITION IS USEFUL TO TREAT THE LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH BENINGA PROSTATIC HYPERPLASIA (BPH)

PE2001000130A 2000-02-09 2001-02-07 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ALPHA-ADRENORECEPTOR ANTAGONIST AND A MUSCARINAL ANTAGONIST FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA PE20011167A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18131000P 2000-02-09 2000-02-09

Publications (1)

Publication Number Publication Date
PE20011167A1 true PE20011167A1 (en) 2001-11-13

Family

ID=22663745

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000130A PE20011167A1 (en) 2000-02-09 2001-02-07 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ALPHA-ADRENORECEPTOR ANTAGONIST AND A MUSCARINAL ANTAGONIST FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

Country Status (12)

Country Link
US (2) US20010044438A1 (en)
EP (2) EP2266571A1 (en)
KR (2) KR20010078803A (en)
AU (3) AU1832901A (en)
CA (1) CA2334460C (en)
HU (1) HU230982B1 (en)
IL (1) IL141235A (en)
MY (1) MY164900A (en)
NZ (1) NZ509807A (en)
PE (1) PE20011167A1 (en)
TW (1) TWI287448B (en)
ZA (1) ZA200101012B (en)

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US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
DE10149674A1 (en) * 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orally administered composition for sustained release of propiverine, useful for treatment of hypertonic bladder disorders, especially by once-daily administration
GB0124455D0 (en) * 2001-10-11 2001-12-05 Pfizer Ltd Pharmaceutical formulations
US7163696B2 (en) 2001-10-11 2007-01-16 Pfizer Inc. Pharmaceutical formulations
US20030185882A1 (en) * 2001-11-06 2003-10-02 Vergez Juan A. Pharmaceutical compositions containing oxybutynin
NL1021822C2 (en) * 2001-11-07 2003-07-15 Synthon Bv Tamsulosin tablets.
DE10221018A1 (en) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Use of inhibitors of EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy
EP1552825A4 (en) * 2002-06-07 2009-11-25 Astellas Pharma Inc Therapeutic agent for overactive bladder
JP2005538139A (en) * 2002-08-14 2005-12-15 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Treatment of lower urinary tract symptoms associated with overactive bladder in men and women
GB0221582D0 (en) * 2002-09-17 2002-10-23 Pfizer Ltd Method of treatment
AU2003207089A1 (en) * 2003-02-14 2004-09-06 Takeda Pharmaceutical Company Limited Preparation for topical administration
WO2005092341A1 (en) * 2004-03-22 2005-10-06 Ranbaxy Laboratories Limited Combination therapy for lower urinary tract symptoms
WO2005092321A1 (en) * 2004-03-24 2005-10-06 Kissei Pharmaceutical Co., Ltd. Pharmaceutical composition for prevention or treatment of increased urinary frequency or involuntary urination
KR100679111B1 (en) * 2004-11-20 2007-02-07 대우약품공업주식회사 Sustained-release tablets containing doxazosin
WO2007010509A2 (en) * 2005-07-22 2007-01-25 Ranbaxy Laboratories Limited Controlled release pharmaceutical composition comprising alpha-adrenergic antagonist and muscarinic antagonist
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
RU2008120332A (en) * 2005-12-20 2010-01-27 Пфайзер Продактс Инк. (Us) PHARMACEUTICAL COMPOSITION FOR TREATMENT OF LUTS CONTAINING A PDE5 INHIBITOR AND MUSCARINE ANTAGONIST
US20090062326A1 (en) * 2006-03-17 2009-03-05 Spindel Eliot R M3 muscarinic receptor antagonists for treatment of m3 muscarinic receptor-expressing tumors
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EP2172201A4 (en) * 2007-07-20 2011-07-06 Astellas Pharma Inc Pharmaceutical composition for amelioration of lower urinary tract symptom associated with prostatomegaly
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
US7891492B2 (en) * 2007-08-13 2011-02-22 Carton Service, Incorporated Pharmaceutical blister card package
EP2181707A1 (en) * 2008-11-04 2010-05-05 Astellas Ireland Co., Ltd. Combined use of an alpha-adrenergic receptor antagonist and an anti-muscarinic agent
DK2451445T3 (en) 2009-07-06 2019-06-24 Boehringer Ingelheim Int PROCEDURE FOR DRYING BIBW2992, IT'S SALTS AND SOLID PHARMACEUTICAL FORMULATIONS INCLUDING THIS ACTIVE INGREDIENT
KR20150048888A (en) * 2012-09-05 2015-05-07 체이스 파마슈티칼스 코포레이션 Anticholinergic neuroprotective composition and methods
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EP3654964B1 (en) * 2017-07-20 2024-04-24 Seinda Pharmaceutical Guangzhou Corporation Composition comprising atropine and a miotic agent and its use in the treatment of myopia
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Also Published As

Publication number Publication date
US7138405B2 (en) 2006-11-21
CA2334460A1 (en) 2001-08-09
EP1123705A1 (en) 2001-08-16
AU2009227918B2 (en) 2011-09-22
HU0100586D0 (en) 2001-03-28
AU2009227918A1 (en) 2009-11-12
HUP0100586A2 (en) 2001-11-28
US20010044438A1 (en) 2001-11-22
ZA200101012B (en) 2002-08-06
HUP0100586A3 (en) 2003-05-28
TWI287448B (en) 2007-10-01
AU2006202176A1 (en) 2006-06-15
IL141235A0 (en) 2011-08-01
US20050222165A1 (en) 2005-10-06
MY164900A (en) 2018-01-30
CA2334460C (en) 2009-01-27
HU230982B1 (en) 2019-08-28
KR20010078803A (en) 2001-08-21
IL141235A (en) 2012-04-30
KR20040032141A (en) 2004-04-14
EP2266571A1 (en) 2010-12-29
NZ509807A (en) 2002-09-27
AU1832901A (en) 2001-08-16

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